Enhancing osteogenesis and angiogenesis functions for Ti-24Nb-4Zr-8Sn scaffolds with methacrylated gelatin and deferoxamine
文献类型：期刊论文
| 作者 | Xu, Qian1,2; Bai, Yun2,3; Li, Shujun2,3; Hou, Wentao2,3; Hao, Yulin2,3; Yang, Rui2,3; Li, Xiaowu1; Zhang, Xing2,3 |
| 刊名 | FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
 |
| 出版日期 | 2024-04-19 |
| 卷号 | 12页码:11 |
| 关键词 | Ti2448 GelMA bone scaffolds deferoxamine angiogenesis |
| ISSN号 | 2296-4185 |
| DOI | 10.3389/fbioe.2024.1372636 |
| 通讯作者 | Li, Xiaowu(xwli@mail.neu.edu.cn) ; Zhang, Xing(xingzhang@imr.ac.cn) |
| 英文摘要 | Repair of large bone defects remains challenge for orthopedic clinical treatment. Porous titanium alloys have been widely fabricated by the additive manufacturing, which possess the elastic modulus close to that of human cortical bone, good osteoconductivity and osteointegration. However, insufficient bone regeneration and vascularization inside the porous titanium scaffolds severely limit their capability for repair of large-size bone defects. Therefore, it is crucially important to improve the osteogenic function and vascularization of the titanium scaffolds. Herein, methacrylated gelatin (GelMA) were incorporated with the porous Ti-24Nb-4Zr-8Sn (Ti2448) scaffolds prepared by the electron beam melting (EBM) method (Ti2448-GelMA). Besides, the deferoxamine (DFO) as an angiogenic agent was doped into the Ti2448-GelMA scaffold (Ti2448-GelMA/DFO), in order to promote vascularization. The results indicate that GelMA can fully infiltrate into the pores of Ti2448 scaffolds with porous cross-linked network (average pore size: 120.2 +/- 25.1 mu m). Ti2448-GelMA scaffolds facilitated the differentiation of MC3T3-E1 cells by promoting the ALP expression and mineralization, with the amount of calcium contents similar to 2.5 times at day 14, compared with the Ti2448 scaffolds. Impressively, the number of vascular meshes for the Ti2448-GelMA/DFO group (similar to 7.2/mm2) was significantly higher than the control group (similar to 5.3/mm2) after cultivation for 9 h, demonstrating the excellent angiogenesis ability. The Ti2448-GelMA/DFO scaffolds also exhibited sustained release of DFO, with a cumulative release of 82.3% after 28 days. Therefore, Ti2448-GelMA/DFO scaffolds likely provide a new strategy to improve the osteogenesis and angiogenesis for repair of large bone defects. |
| 资助项目 | National Natural Science Foundation of China10.13039/501100001809 |
| WOS研究方向 | Biotechnology & Applied Microbiology ; Engineering |
| 语种 | 英语 |
| WOS记录号 | WOS:001216001300001 |
| 出版者 | FRONTIERS MEDIA SA |
| 资助机构 | National Natural Science Foundation of China10.13039/501100001809 |
| 源URL |  |
| 专题 | 金属研究所_中国科学院金属研究所 |
| 通讯作者 | Li, Xiaowu; Zhang, Xing |
| 作者单位 | 1.Northeastern Univ, Sch Mat Sci & Engn, Dept Mat Phys & Chem, Minist Educ,Key Lab Anisotropy & Texture Mat, Shenyang, Liaoning, Peoples R China 2.Chinese Acad Sci, Inst Met Res, Shenyang, Liaoning, Peoples R China 3.Univ Sci & Technol China, Sch Mat Sci & Engn, Hefei, Anhui, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xu, Qian,Bai, Yun,Li, Shujun,et al. Enhancing osteogenesis and angiogenesis functions for Ti-24Nb-4Zr-8Sn scaffolds with methacrylated gelatin and deferoxamine[J]. FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY,2024,12:11. |
| APA | Xu, Qian.,Bai, Yun.,Li, Shujun.,Hou, Wentao.,Hao, Yulin.,...&Zhang, Xing.(2024).Enhancing osteogenesis and angiogenesis functions for Ti-24Nb-4Zr-8Sn scaffolds with methacrylated gelatin and deferoxamine.FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY,12,11. |
| MLA | Xu, Qian,et al."Enhancing osteogenesis and angiogenesis functions for Ti-24Nb-4Zr-8Sn scaffolds with methacrylated gelatin and deferoxamine".FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY 12(2024):11. |
入库方式： OAI收割
来源：金属研究所
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