Porous Ti3SiC2 ceramics with improved osteogenic functions via biomineralization as load-bearing bone implants
文献类型：期刊论文
| 作者 | Xu, Qian1,2; Wang, Shuze4; Bai, Yun2,3; Wang, Qiang4; Yang, Rui2,3; Wang, Xiaohui2,3; Li, Xiaowu1; Zhang, Xing2,3 |
| 刊名 | JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
 |
| 出版日期 | 2024-10-01 |
| 卷号 | 195页码:248-259 |
| 关键词 | Ti3 SiC2 scaffolds Biomineralization Macrophage polarization Bone regeneration |
| ISSN号 | 1005-0302 |
| DOI | 10.1016/j.jmst.2024.01.025 |
| 通讯作者 | Wang, Xiaohui(wang@imr.ac.cn) ; Li, Xiaowu(xwli@mail.neu.edu.cn) ; Zhang, Xing(xingzhang@imr.ac.cn) |
| 英文摘要 | Ti3SiC2 ceramics exhibit excellent mechanical properties and good biocompatibility, rendering them promising bone substitutes for load-bearing conditions. However, the bone integration and osteogenic ability of Ti3SiC2 ceramics remain unclear. Herein, porous Ti3SiC2 ceramics were prepared and systematically investigated as bone scaffolds. The Ti3SiC2 scaffolds with a porosity of 62.9 % +/- 2.5 % showed high compressive strength similar to 68.12 +/- 4.33 MPa. Silicon hydroxyl groups formed on the surface of Ti3SiC2 after soaking in simulated body fluid, which played a critical role in the apatite mineralization of the scaffolds. Biomineralization of Ti3SiC2 scaffolds was found when implanted subcutaneously in the rat dorsum for 2 weeks, demonstrating good osteogenesis ability. The apatite mineralization of the Ti3SiC2 scaffold facilitated the polarization of RAW264.7 cells from M1 to M2 phenotype, which also promoted the differentiation of MC3T3-E1 cells. The porous Ti3SiC2 scaffolds improved osteointegration and bone regeneration after implantation in rabbit femoral defects. Impressively, the number of the newly formed trabeculae in the Ti3SiC2 group was three times of the control group after implantation for 8 weeks, showing excellent bone defect repair. This work demonstrates that Ti3SiC2 implants with improved biological functions likely via in -situ biomineralization are promising candidates for bone regeneration. (c) 2024 Published by Elsevier Ltd on behalf of The editorial office of Journal of Materials Science & Technology. |
| 资助项目 | National Natural Science Foundation of China[52273278] ; Liaoning Revitalization Talents Program[XLYC2007112] |
| WOS研究方向 | Materials Science ; Metallurgy & Metallurgical Engineering |
| 语种 | 英语 |
| WOS记录号 | WOS:001230440700001 |
| 出版者 | JOURNAL MATER SCI TECHNOL |
| 资助机构 | National Natural Science Foundation of China ; Liaoning Revitalization Talents Program |
| 源URL |  |
| 专题 | 金属研究所_中国科学院金属研究所 |
| 通讯作者 | Wang, Xiaohui; Li, Xiaowu; Zhang, Xing |
| 作者单位 | 1.Northeastern Univ, Sch Mat Sci & Engn, Dept Mat Phys & Chem, Key Lab Anisotropy & Texture Mat,Minist Educ, Shenyang 110819, Peoples R China 2.Chinese Acad Sci, Inst Met Res, Shenyang 110016, Peoples R China 3.Univ Sci & Technol China, Sch Mat Sci & Engn, Hefei 230026, Peoples R China 4.China Med Univ, Sch & Hosp Stomatol, Liaoning Prov Key Lab Oral Dis, Shenyang 110001, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xu, Qian,Wang, Shuze,Bai, Yun,et al. Porous Ti3SiC2 ceramics with improved osteogenic functions via biomineralization as load-bearing bone implants[J]. JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY,2024,195:248-259. |
| APA | Xu, Qian.,Wang, Shuze.,Bai, Yun.,Wang, Qiang.,Yang, Rui.,...&Zhang, Xing.(2024).Porous Ti3SiC2 ceramics with improved osteogenic functions via biomineralization as load-bearing bone implants.JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY,195,248-259. |
| MLA | Xu, Qian,et al."Porous Ti3SiC2 ceramics with improved osteogenic functions via biomineralization as load-bearing bone implants".JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY 195(2024):248-259. |
入库方式： OAI收割
来源：金属研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。