Nano-ZnO-modified hydroxyapatite whiskers with enhanced osteoinductivity for bone defect repair
文献类型：期刊论文
| 作者 | Wei, Penggong1,2; Wang, Ning3; Zhang, Qiyue1,2; Wang, Wanfeng1,2; Sun, Hui1,2; Liu, Zengqian4; Yan, Tingting5; Wang, Qiang1,2; Qiu, Lihong1,2 |
| 刊名 | REGENERATIVE BIOMATERIALS
 |
| 出版日期 | 2024-06-07 |
| 卷号 | 11页码:16 |
| 关键词 | hydroxyapatite whisker nano-zinc oxide particles surface modification mechanical damage osteoblast differentiation bone defect repair |
| ISSN号 | 2056-3418 |
| DOI | 10.1093/rb/rbae051 |
| 通讯作者 | Yan, Tingting(yan@kust.edu.cn) ; Wang, Qiang(mfqwang@cmu.edu.cn) ; Qiu, Lihong(lhqiu@cmu.edu.cn) |
| 英文摘要 | Hydroxyapatite (HA) whisker (HAw) represents a distinct form of HA characterized by its high aspect ratio, offering significant potential for enhancing the mechanical properties of bone tissue engineering scaffolds. However, the limited osteoinductivity of HAw hampers its widespread application. In this investigation, we observed HAw-punctured osteoblast membranes and infiltrated the cell body, resulting in mechanical damage to cells that adversely impacted osteoblast proliferation and differentiation. To address this challenge, we developed nano-zinc oxide particle-modified HAw (nano-ZnO/HAw). Acting as a reinforcing and toughening agent, nano-ZnO/HAw augmented the compressive strength and ductility of the matrix materials. At the same time, the surface modification with nano-ZnO particles improved osteoblast differentiation by reducing the mechanical damage from HAw to cells and releasing zinc ion, the two aspects collectively promoted the osteoinductivity of HAw. Encouragingly, the osteoinductive potential of 5% nano-ZnO/HAw and 10% nano-ZnO/HAw was validated in relevant rat models, demonstrating the efficacy of this approach in promoting new bone formation in vivo. Our findings underscore the role of nano-ZnO particle surface modification in enhancing the osteoinductivity of HAw from a physical standpoint, offering valuable insights into the development of bone substitutes with favorable osteoinductive properties while simultaneously bolstering matrix material strength and toughness. |
| 资助项目 | National Key R&D Program of China[2020YFA0710404] ; Liaoning Medical-Engineering Joint Fund[2022-YGJC-01] ; Yanglei Academician Expert Workstation of Yunnan Province[202205AF15025] ; Yunnan Innovation Team of Graphene Mechanism Research and Application Industrialization[202305AS350017] |
| WOS研究方向 | Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:001240648700001 |
| 出版者 | OXFORD UNIV PRESS |
| 资助机构 | National Key R&D Program of China ; Liaoning Medical-Engineering Joint Fund ; Yanglei Academician Expert Workstation of Yunnan Province ; Yunnan Innovation Team of Graphene Mechanism Research and Application Industrialization |
| 源URL |  |
| 专题 | 金属研究所_中国科学院金属研究所 |
| 通讯作者 | Yan, Tingting; Wang, Qiang; Qiu, Lihong |
| 作者单位 | 1.China Med Univ, Sch & Hosp Stomatol, Shenyang 110002, Peoples R China 2.Liaoning Prov Key Lab Oral Dis, Shenyang 110002, Peoples R China 3.China Med Univ, Hosp 1, Dept Plast Surg, Shenyang 110001, Peoples R China 4.Chinese Acad Sci, Inst Met Res, Shi Changxu Innovat Ctr Adv Mat, Shenyang 110016, Peoples R China 5.Kunming Univ Sci & Technol, Fac Mat Sci & Engn, Kunming 650093, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wei, Penggong,Wang, Ning,Zhang, Qiyue,et al. Nano-ZnO-modified hydroxyapatite whiskers with enhanced osteoinductivity for bone defect repair[J]. REGENERATIVE BIOMATERIALS,2024,11:16. |
| APA | Wei, Penggong.,Wang, Ning.,Zhang, Qiyue.,Wang, Wanfeng.,Sun, Hui.,...&Qiu, Lihong.(2024).Nano-ZnO-modified hydroxyapatite whiskers with enhanced osteoinductivity for bone defect repair.REGENERATIVE BIOMATERIALS,11,16. |
| MLA | Wei, Penggong,et al."Nano-ZnO-modified hydroxyapatite whiskers with enhanced osteoinductivity for bone defect repair".REGENERATIVE BIOMATERIALS 11(2024):16. |
入库方式： OAI收割
来源：金属研究所
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