Biodegradable high-nitrogen iron alloy anastomotic staples: In vitro and in vivo studies
文献类型：期刊论文
| 作者 | Lu, Sihan2; Wang, Peng3; Wang, Qingchuan1,9; Deng, Peng4; Yuan, Yonghui5; Fu, Xiaoqing1; Yang, Yinghui6; Tan, Lili1; Yang, Ke1; Qi, Xun7,8 |
| 刊名 | BIOACTIVE MATERIALS
 |
| 出版日期 | 2024-10-01 |
| 卷号 | 40页码:34-46 |
| 关键词 | High-nitrogen Iron alloy Surgical staples Mechanical property Degradation |
| DOI | 10.1016/j.bioactmat.2024.06.005 |
| 通讯作者 | Wang, Qingchuan(qcwang11s@imr.ac.cn) ; Yang, Ke(kyang@imr.ac.cn) ; Qi, Xun(qixun716@hotmail.com) |
| 英文摘要 | For gastrointestinal anastomosis, metallic biodegradable staples have a broad application potential. However, both magnesium and zinc alloys have relatively low strength to withstand the repeated peristalsis of the gastrointestinal tract. In this study, we developed a novel kind of biodegradable high-nitrogen iron (HN-Fe) alloy wires (0.23 mm), which were fabricated into the staples. The tensile results showed that the ultimate tensile strength and elongation of HN-Fe wires were 1023.2 MPa and 51.0 %, respectively, which was much higher than those of other biodegradable wires. The degradation rate in vitro of HN-Fe wires was slightly higher than that of pure Fe wires. After 28 days of immersion, the tensile strength of HN-Fe wires remained not less than 240 MPa, meeting the clinical requirements. Furthermore, sixteen rabbits were enrolled to conduct a comparison experiment using HN-Fe and clinical Ti staples for gastroanastomosis. After 6 months of implantation, a homogeneous degradation product layer on HN-Fe staples was observed and no fracture occurred. The degradation rate of HN-Fe staples in vivo was significantly higher than that in vitro, and they were expected to be completely degraded in 2 years. Meanwhile, both benign cutting and closure performance of HN-Fe staples ensured that all the animals did not experience hemorrhage and anastomotic fistula during the observation. The anastomosis site healed without histopathological change, inflammatory reaction and abnormal blood routine and biochemistry, demonstrating good biocompatibility of HN-Fe staples. Thereby, the favorable performance makes the HN-Fe staples developed in this work a promising candidate for gastrointestinal anastomosis. |
| 资助项目 | National Natural Science Foundation of China[82272099] ; National Natural Science Foundation of China[51971222] ; National Natural Science Foundation of China[51801220] ; Construction Project of Liaoning Medical Imaging and Interventional Medical Engineering Research Center[18-006-9-01] ; STS program[20201600200042] ; DongGuan Innovative Research Team Program[2020607134012] ; Basic Applied Research Program of Liaoning Province of China[2022020347-JH2/1013] ; Basic Applied Research Program of Liaoning Province of China[2023JH26/103000016] |
| WOS研究方向 | Engineering ; Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:001250661800001 |
| 出版者 | KEAI PUBLISHING LTD |
| 资助机构 | National Natural Science Foundation of China ; Construction Project of Liaoning Medical Imaging and Interventional Medical Engineering Research Center ; STS program ; DongGuan Innovative Research Team Program ; Basic Applied Research Program of Liaoning Province of China |
| 源URL |  |
| 专题 | 金属研究所_中国科学院金属研究所 |
| 通讯作者 | Wang, Qingchuan; Yang, Ke; Qi, Xun |
| 作者单位 | 1.Chinese Acad Sci, Inst Met Res, Shenyang 110016, Peoples R China 2.China Med Univ, Sch Intelligent Med, Shenyang 110122, Peoples R China 3.China Med Univ, Dept Intervent Therapy, Hosp 1, Shenyang 110001, Peoples R China 4.China Med Univ, Dept Surg Oncol & Gen Surg, Hosp 1, Shenyang 110001, Peoples R China 5.China Med Univ, Liaoning Canc Hosp & Inst, Canc Hosp, Clin Res Ctr Malignant Tumor Liaoning Prov, Shenyang 110801, Peoples R China 6.Silvan Med Device Co Ltd, Suzhou 215004, Peoples R China 7.China Med Univ, Hosp 1, Dept Radiol, Key Lab Diagnost Imaging & Intervent Radiol Liaoni, Shenyang 110001, Peoples R China 8.Nanjing North St, Shenyang 110001, Liaoning, Peoples R China 9.Wenhua Rd, Shenyang 110016, Liaoning, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lu, Sihan,Wang, Peng,Wang, Qingchuan,et al. Biodegradable high-nitrogen iron alloy anastomotic staples: In vitro and in vivo studies[J]. BIOACTIVE MATERIALS,2024,40:34-46. |
| APA | Lu, Sihan.,Wang, Peng.,Wang, Qingchuan.,Deng, Peng.,Yuan, Yonghui.,...&Qi, Xun.(2024).Biodegradable high-nitrogen iron alloy anastomotic staples: In vitro and in vivo studies.BIOACTIVE MATERIALS,40,34-46. |
| MLA | Lu, Sihan,et al."Biodegradable high-nitrogen iron alloy anastomotic staples: In vitro and in vivo studies".BIOACTIVE MATERIALS 40(2024):34-46. |
入库方式： OAI收割
来源：金属研究所
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