Construction of a Titanium-Magnesium Composite Internal Fixation System for Repairing Bone Defects
文献类型：期刊论文
| 作者 | Yang, Zhongheng1; Lu, Jiarui2; Yan, Tao3; Ibrahim, Muhammad4,5; Wang, Qingchuan4; Tan, Lili4; Wang, Qiang2; Mu, Yabing6; Gao, Yuzhong1 |
| 刊名 | ACS BIOMATERIALS SCIENCE & ENGINEERING
 |
| 出版日期 | 2024-08-20 |
| 页码 | 16 |
| 关键词 | Titanium-magnesium composite Bone defect Bone repair Macrophage polarization Osteogenicdifferentiation |
| ISSN号 | 2373-9878 |
| DOI | 10.1021/acsbiomaterials.4c00949 |
| 通讯作者 | Tan, Lili(lltan@imr.ac.cn) ; Gao, Yuzhong(gaoyz@jzmu.edu.cn) |
| 英文摘要 | The repair and regeneration of maxillofacial bone defects are major clinical challenges. Titanium (Ti)-magnesium (Mg) composites are a new generation of revolutionary internal fixation materials encompassing the mechanical strength and bioactive advantages of Ti and Mg alloys, respectively. This study was aimed to construct a Ti-Mg composite internal plate/screw fixation system to fix and repair bone defects. Further, the effects of different internal fixation systems on bone repair were analyzed through radiological and histological analyses. Notably, Ti6Al4V with rolled Mg foil was used as the experimental group, and a bone defect model of transverse complete amputation of the ulna in rabbits similar to the clinical condition was established. The internal fixation system with the highest osteogenic efficiency was selected based on in vivo results, and the direct and indirect bone repair abilities of the selected materials were evaluated in vitro. Notably, the thin Mg foil-Ti6Al4V internal fixation system exhibited the best fixation effect in the bone defect model and promoted the formation of new bone and early healing of bone defect areas. In vitro, the thin Mg foil-Ti6Al4V composite enhanced the activity of MC3T3-E1 cells; promoted the proliferation, adhesion, extension, and osteogenic differentiation of MC3T3-E1 cells; and regulated new bone formation. Further, it also promoted the polarization of RAW264.7 cells to M2 macrophages, induced the osteogenic immune microenvironment, and indirectly regulated the bone repair process. Therefore, a internal fixation system holds a promising potential for the internal fixation of maxillofacial bone defects. Our findings provide a theoretical and scientific basis for the design and clinical application of Ti-Mg internal fixation systems. |
| 资助项目 | Liaoning Provincial Natural Science Foundation of China[2022-MS-212] ; Central Guidance Funding for Local Scientific and Technological Development in Liaoning[2023JH6/100100029] ; Liaoning Department of Education Projects[LJKMZ20221225] |
| WOS研究方向 | Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:001295106500001 |
| 出版者 | AMER CHEMICAL SOC |
| 资助机构 | Liaoning Provincial Natural Science Foundation of China ; Central Guidance Funding for Local Scientific and Technological Development in Liaoning ; Liaoning Department of Education Projects |
| 源URL |  |
| 专题 | 金属研究所_中国科学院金属研究所 |
| 通讯作者 | Tan, Lili; Gao, Yuzhong |
| 作者单位 | 1.Jinzhou Med Univ, Affiliated Hosp 1, Jinzhou 121000, Liaoning, Peoples R China 2.China Med Univ, Sch & Hosp Stomatol, Liaoning Prov Key Lab Oral Dis, Shenyang 110001, Peoples R China 3.China Med Univ, Peoples Hosp, Dept Orthoped & Sports Med & Joint Surg, Shenyang 110016, Liaoning, Peoples R China 4.Chinese Acad Sci, Inst Met Res, Shenyang 110016, Peoples R China 5.Univ Sci & Technol China, Sch Mat Sci & Engn, Shenyang 110016, Peoples R China 6.Umea Univ, Dept Med Biosci, Bldg 6M, SE-90185 Umea, Sweden |
| 推荐引用方式 GB/T 7714 | Yang, Zhongheng,Lu, Jiarui,Yan, Tao,et al. Construction of a Titanium-Magnesium Composite Internal Fixation System for Repairing Bone Defects[J]. ACS BIOMATERIALS SCIENCE & ENGINEERING,2024:16. |
| APA | Yang, Zhongheng.,Lu, Jiarui.,Yan, Tao.,Ibrahim, Muhammad.,Wang, Qingchuan.,...&Gao, Yuzhong.(2024).Construction of a Titanium-Magnesium Composite Internal Fixation System for Repairing Bone Defects.ACS BIOMATERIALS SCIENCE & ENGINEERING,16. |
| MLA | Yang, Zhongheng,et al."Construction of a Titanium-Magnesium Composite Internal Fixation System for Repairing Bone Defects".ACS BIOMATERIALS SCIENCE & ENGINEERING (2024):16. |
入库方式： OAI收割
来源：金属研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。