Impacts of Environmental Concentrations of Nanoplastics on Zebrafish Neurobehavior and Reproductive Toxicity
文献类型：期刊论文
| 作者 | Sun, Ziqing1; Wu, Baihui2; Yi, Jia2; Yu, Haiyang2; He, Jiaxuan2; Teng, Fei3; Xi, Tong1; Zhao, Jinlong1; Ruan, Jing2; Xu, Peiye2 |
| 刊名 | TOXICS
 |
| 出版日期 | 2024-08-01 |
| 卷号 | 12期号:8页码:17 |
| 关键词 | environmental pollutants polystyrene nanoplastics reproductive and neurobehavioral effects mechanism oxidative stress |
| DOI | 10.3390/toxics12080617 |
| 通讯作者 | Sun, Ziqing(zqsun@imr.ac.cn) ; Ji, Hao(20180031@wzu.edu.cn) |
| 英文摘要 | Nanoplastics, as emerging environmental pollutants, can transport contaminants across marine environments, polluting pristine ecosystems and being ingested by marine organisms. This transfer poses a severe threat to global aquatic ecosystems and potentially impacts human health through the food chain. Neurobehavioral and reproductive toxicity are critical areas of concern because they directly affect the survival, health, and population dynamics of aquatic species, which can have cascading effects on the entire ecosystem. Using zebrafish as a model organism, we investigated the toxic effects of environmental concentrations of polystyrene nanoplastics (PS-NPs). Behavioral assessments, including the novel tank test and open field test, demonstrated significant neurobehavioral changes, indicating increased anxiety and depressive behaviors. A pathological analysis of brain and gonadal tissues, along with evaluations of neurobehavioral and reproductive toxicity biomarkers, revealed that exposure to PS-NPs leads to brain tissue lesions, inflammatory responses, oxidative stress activation, hormone level disruptions, and gonadal damage. Real-time quantitative PCR studies of reproductive gene expression further showed that PS-NPs disrupt the endocrine regulation pathways of the brain-pituitary-gonadal (BPG) axis, causing reproductive toxicity with sex-specific differences. These findings provide crucial insights into the impacts of nanoplastics on aquatic organisms and their ecological risks, offering theoretical support for future environmental protection and pollutant management efforts. |
| 资助项目 | National Natural Science Foundation of China ; Natural Science Foundation of Medical and Industrial Cross Joint of Liaoning Province[2022-YGJC-54] ; Natural Science Foundation of Liaoning Province[2023-MS-025] ; [52101293] |
| WOS研究方向 | Environmental Sciences & Ecology ; Toxicology |
| 语种 | 英语 |
| WOS记录号 | WOS:001307445200001 |
| 出版者 | MDPI |
| 资助机构 | National Natural Science Foundation of China ; Natural Science Foundation of Medical and Industrial Cross Joint of Liaoning Province ; Natural Science Foundation of Liaoning Province |
| 源URL |  |
| 专题 | 金属研究所_中国科学院金属研究所 |
| 通讯作者 | Sun, Ziqing; Ji, Hao |
| 作者单位 | 1.Chinese Acad Sci, Inst Met Res, 72 Wenhua Rd, Shenyang 110016, Peoples R China 2.Wenzhou Univ, Inst Life Sci & Biomed Collaborat Innovat Ctr Zhej, Wenzhou 325035, Peoples R China 3.Shenyang Aerosp Univ, Civil Aviat Coll, Shenyang 110136, Peoples R China 4.Shenyang Agr Univ, Coll Anim Sci & Vet Med, Shenyang 110866, Peoples R China |
| 推荐引用方式 GB/T 7714 | Sun, Ziqing,Wu, Baihui,Yi, Jia,et al. Impacts of Environmental Concentrations of Nanoplastics on Zebrafish Neurobehavior and Reproductive Toxicity[J]. TOXICS,2024,12(8):17. |
| APA | Sun, Ziqing.,Wu, Baihui.,Yi, Jia.,Yu, Haiyang.,He, Jiaxuan.,...&Ji, Hao.(2024).Impacts of Environmental Concentrations of Nanoplastics on Zebrafish Neurobehavior and Reproductive Toxicity.TOXICS,12(8),17. |
| MLA | Sun, Ziqing,et al."Impacts of Environmental Concentrations of Nanoplastics on Zebrafish Neurobehavior and Reproductive Toxicity".TOXICS 12.8(2024):17. |
入库方式： OAI收割
来源：金属研究所
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