3D chitosan scaffolds loaded with ZnO nanoparticles for bone tissue engineering
文献类型：期刊论文
| 作者 | Tang, Wenmin1; Pan, Peng2,3; Chen, Tiantian2,3; Wang, Jian4; Cui, Xiangnan1; Liu, Wentao2,3; Kan, Liang1 |
| 刊名 | COLLOIDS AND SURFACES B-BIOINTERFACES
 |
| 出版日期 | 2025 |
| 卷号 | 245页码:9 |
| 关键词 | Zinc oxide nanoparticles Chitosan Tissue engineering scaffold Bone repair |
| ISSN号 | 0927-7765 |
| DOI | 10.1016/j.colsurfb.2024.114199 |
| 通讯作者 | Liu, Wentao(wtliu@imr.ac.cn) ; Kan, Liang(kanl@sj-hospital.org) |
| 英文摘要 | Bone defect has always been a difficult problem in clinical work. According to the current research results, tissue engineered scaffolds with a single function, structure, and composition are not sufficient to repair complex bone defects. In this work, a three-dimensional (3D) chitosan degradable composite scaffold loaded with zinc oxide (ZnO) was constructed, and the effect of ZnO content on scaffold performance and osteogenesis was explored. The 3D composite scaffold was prepared by freeze-drying technology. The microstructure, porosity, degradation performance, release performance, swelling performance, cytotoxicity, cell adhesion and osteogenic ability of ZnO nanoparticles and chitosan (ZnONPs/CS) composite scaffolds were measured. The results show that an appropriate amount of ZnO may be helpful to regulate the stability and degradation characteristics of the scaffold to a certain extent. Moreover, the composite scaffold could release ZnO into the simulated body fluid environment. The appropriate amount of ZnO helps to promote the proliferation, adhesion, and osteogenic differentiation of MC3T3-E1 cells. At a ZnO content of 3 wt%, both in vitro and vivo results showed relatively optimal biocompatibility and bioactivity of the scaffolds. This work could at least provide some positive insights for the selection of ZnO dosage, construction of chitosan-based 3D scaffolds, tissue engineering applications, and clinical treatment. |
| 资助项目 | Natural Science Foundation of Liaoning Province[2022-YGJC-02] ; Applied Basic Research Programs of Liaoning Province[2022JH2/101300104] ; Young Talents Project of Shenyang National Laboratory for Materials Science[E01SL607] |
| WOS研究方向 | Biophysics ; Chemistry ; Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:001307966000001 |
| 出版者 | ELSEVIER |
| 资助机构 | Natural Science Foundation of Liaoning Province ; Applied Basic Research Programs of Liaoning Province ; Young Talents Project of Shenyang National Laboratory for Materials Science |
| 源URL |  |
| 专题 | 金属研究所_中国科学院金属研究所 |
| 通讯作者 | Liu, Wentao; Kan, Liang |
| 作者单位 | 1.China Med Univ, Shengjing Hosp, Dept Geriatr, Shenyang 110004, Liaoning, Peoples R China 2.Chinese Acad Sci, Inst Met Res, Shenyang Natl Lab Mat Sci, Shenyang 110016, Peoples R China 3.Univ Sci & Technol China, Sch Mat Sci & Engn, Shenyang 110016, Peoples R China 4.Jinzhou Med Univ, Affiliated Hosp 1, Dept Orthoped, Jinzhou 121000, Peoples R China |
| 推荐引用方式 GB/T 7714 | Tang, Wenmin,Pan, Peng,Chen, Tiantian,et al. 3D chitosan scaffolds loaded with ZnO nanoparticles for bone tissue engineering[J]. COLLOIDS AND SURFACES B-BIOINTERFACES,2025,245:9. |
| APA | Tang, Wenmin.,Pan, Peng.,Chen, Tiantian.,Wang, Jian.,Cui, Xiangnan.,...&Kan, Liang.(2025).3D chitosan scaffolds loaded with ZnO nanoparticles for bone tissue engineering.COLLOIDS AND SURFACES B-BIOINTERFACES,245,9. |
| MLA | Tang, Wenmin,et al."3D chitosan scaffolds loaded with ZnO nanoparticles for bone tissue engineering".COLLOIDS AND SURFACES B-BIOINTERFACES 245(2025):9. |
入库方式： OAI收割
来源：金属研究所
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