Quorum quenching as a mechanism for Cu-bearing stainless steel to conduct nonbiocidal retardation of biofilm development
文献类型：期刊论文
| 作者 | Zhang, Xinrui1; Sun, BeiBei2; Xi, Tong1; Zhao, Jinlong1; Yang, Ke1; Sun, Siyu2; Yang, Chunguang1 |
| 刊名 | CHEMICAL ENGINEERING JOURNAL
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| 出版日期 | 2024-11-01 |
| 卷号 | 499页码:12 |
| 关键词 | Biofilms Quorum quenching Cu-bearing stainless steel Reactive oxygen species |
| ISSN号 | 1385-8947 |
| DOI | 10.1016/j.cej.2024.155996 |
| 通讯作者 | Sun, Siyu(sunsy@sj-hospital.org) ; Yang, Chunguang(cgyang@imr.ac.cn) |
| 英文摘要 | Bacterial contamination induced by stubborn biofilms has threatened many industries. Significant efforts have concentrated on mitigating surface-associated biofilms with focus on killing or removing bacterial cells, which are always short duration and suboptimal inhibition on biofilms. Here, we reported a sustainable and nonbiocidal strategy of control biofilms by applying a Cu-bearing stainless steel (SS) to interrupt quorum sensing (QS), mentioned as quorum quenching (QQ). It was found that Cu-bearing SS with the micro-galvanic couples structure consisting of the precipitated Cu-rich phases and the matrix triggers charge transfer reactions with bacteria/ media, resulting in an overexpression of reactive oxygen species (ROS), which is responsible for QQ. Studies with luxS-delated mutant which cannot mediate the QS mechanism confirmed that QS could be the target for antibacterial metals to produce a sub-/non-lethal biofilm structural inhibition. And inducing ROS production has been a strategy to endow metals with QQ ability. Thereby, defective biofilms with the QS deletion phenotype would be gratifying to provide a sufficient window period for effective decontamination, curbing the solid surface as for contamination spreader. This research introduces a promising and practical QQ strategy for combating bacterial contamination from the root in active microbial environments, providing insights into the material modifications. |
| 资助项目 | National Natural Science Foundation of China[52301307] ; National Natural Science Foundation of China[52101293] ; National Natural Science Foundation of China[52001311] ; Natural Science Foundation of Medical and Industrial Cross Joint of Liaoning Province[2022-YGJC-54] ; Peak Climbing Project of Foshan Hospital of Traditional Chinese Medicine[202000206] ; Technology Innovation of Foshan City[2020001004942] ; IMR Innovation Fund[2022-PY18] ; Research and Development of Special Stainless Steel for Medical Use with High Strength and Corrosion Resistant[2024C01151] |
| WOS研究方向 | Engineering |
| 语种 | 英语 |
| WOS记录号 | WOS:001327764600001 |
| 出版者 | ELSEVIER SCIENCE SA |
| 资助机构 | National Natural Science Foundation of China ; Natural Science Foundation of Medical and Industrial Cross Joint of Liaoning Province ; Peak Climbing Project of Foshan Hospital of Traditional Chinese Medicine ; Technology Innovation of Foshan City ; IMR Innovation Fund ; Research and Development of Special Stainless Steel for Medical Use with High Strength and Corrosion Resistant |
| 源URL |  |
| 专题 | 金属研究所_中国科学院金属研究所 |
| 通讯作者 | Sun, Siyu; Yang, Chunguang |
| 作者单位 | 1.Chinese Acad Sci, Inst Met Res, Shenyang 110016, Peoples R China 2.China Med Univ, Dept Gastroenterol, Shengjing Hosp, Shenyang 110016, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Xinrui,Sun, BeiBei,Xi, Tong,et al. Quorum quenching as a mechanism for Cu-bearing stainless steel to conduct nonbiocidal retardation of biofilm development[J]. CHEMICAL ENGINEERING JOURNAL,2024,499:12. |
| APA | Zhang, Xinrui.,Sun, BeiBei.,Xi, Tong.,Zhao, Jinlong.,Yang, Ke.,...&Yang, Chunguang.(2024).Quorum quenching as a mechanism for Cu-bearing stainless steel to conduct nonbiocidal retardation of biofilm development.CHEMICAL ENGINEERING JOURNAL,499,12. |
| MLA | Zhang, Xinrui,et al."Quorum quenching as a mechanism for Cu-bearing stainless steel to conduct nonbiocidal retardation of biofilm development".CHEMICAL ENGINEERING JOURNAL 499(2024):12. |
入库方式： OAI收割
来源：金属研究所
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