Porous metal materials for applications in orthopedic field: A review on mechanisms in bone healing
文献类型：期刊论文
| 作者 | Ma, Yutong2; Wang, Yi3; Tong, Shuang1; Wang, Yuehan3; Wang, Zhuoya3; Sui, Rongze3; Yang, Ke4; Witte, Frank5; Yang, Shude1 |
| 刊名 | JOURNAL OF ORTHOPAEDIC TRANSLATION
 |
| 出版日期 | 2024-11-01 |
| 卷号 | 49页码:135-155 |
| 关键词 | Angiogenesis Bone regeneration Immunomodulation Osteogenesis Porous metal materials |
| ISSN号 | 2214-031X |
| DOI | 10.1016/j.jot.2024.08.003 |
| 通讯作者 | Yang, Ke(kyang@imr.ac.cn) ; Witte, Frank(frank.witte@charite.de) ; Yang, Shude(sdyang@cmu.edu.cn) |
| 英文摘要 | Background: Porous metal materials have been widely studied for applications in orthopedic field, owing to their excellent features and properties in bone healing. Porous metal materials with different compositions, manufacturing methods, and porosities have been developed. Whereas, the systematic mechanisms on how porous metal materials promote bone healing still remain unclear. Methods: This review is concerned on the porous metal materials from three aspects with accounts of specific mechanisms, inflammatory regulation, angiogenesis and osteogenesis. We place great emphasis on different cells regulated by porous metal materials, including mesenchymal stem cells (MSCs), macrophages, endothelial cells (ECs), etc. Result: The design of porous metal materials is diversified, with its varying pore sizes, porosity material types, modification methods and coatings help researchers create the most experimentally suitable and clinically effective scaffolds. Related signal pathways presented from different functions showed that porous metal materials could change the behavior of cells and the amount of cytokines, achieving good influence on osteogenesis. Conclusion: This article summarizes the current progress achieved in the mechanism of porous metal materials promoting bone healing. By modulating the cellular behavior and physiological status of a spectrum of cellular constituents, such as macrophages, osteoblasts, and osteoclasts, porous metal materials are capable of activating different pathways and releasing regulatory factors, thus exerting pivotal influence on improving the bone healing effect. The translational potential of this article: Porous metal materials play a vital role in the treatment of bone defects. Unfortunately, although an increasing number of studies have been concentrated on the effect of porous metal materials on osteogenesis-related cells, the comprehensive regulation of porous metal materials on the host cell functions during bone regeneration and the related intrinsic mechanisms remain unclear. This review summarizes different design methods for porous metal materials to fabricate the most suitable scaffolds for bone remodeling, and systematically reviews the corresponding mechanisms on inflammation, angiogenesis and osteogenesis of porous metal materials. This review can provide more theoretical framework and innovative optimization for the application of porous metal materials in orthopedics, dentistry, and other areas, thereby advancing their clinical utility and efficacy. |
| 资助项目 | National Natural Science Foundation of China[82301045] |
| WOS研究方向 | Orthopedics |
| 语种 | 英语 |
| WOS记录号 | WOS:001335232000001 |
| 出版者 | ELSEVIER |
| 资助机构 | National Natural Science Foundation of China |
| 源URL |  |
| 专题 | 金属研究所_中国科学院金属研究所 |
| 通讯作者 | Yang, Ke; Witte, Frank; Yang, Shude |
| 作者单位 | 1.China Med Univ, Dept Plast Surg, Hosp 1, Shenyang 110001, Peoples R China 2.China Med Univ, Dept Breast Surg, Hosp 1, Shenyang 110001, Peoples R China 3.China Med Univ, Clin Coll 1, Shenyang 110001, Peoples R China 4.Chinese Acad Sci, Inst Met Res, Shenyang 110016, Peoples R China 5.Charite Med Univ, Dept Prosthodont Geriatr Dent & Craniomandibular D, Assmannshauser Str 4-6, D-14197 Berlin, Germany |
| 推荐引用方式 GB/T 7714 | Ma, Yutong,Wang, Yi,Tong, Shuang,et al. Porous metal materials for applications in orthopedic field: A review on mechanisms in bone healing[J]. JOURNAL OF ORTHOPAEDIC TRANSLATION,2024,49:135-155. |
| APA | Ma, Yutong.,Wang, Yi.,Tong, Shuang.,Wang, Yuehan.,Wang, Zhuoya.,...&Yang, Shude.(2024).Porous metal materials for applications in orthopedic field: A review on mechanisms in bone healing.JOURNAL OF ORTHOPAEDIC TRANSLATION,49,135-155. |
| MLA | Ma, Yutong,et al."Porous metal materials for applications in orthopedic field: A review on mechanisms in bone healing".JOURNAL OF ORTHOPAEDIC TRANSLATION 49(2024):135-155. |
入库方式： OAI收割
来源：金属研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。