Anti-infective Ti-Cu alloy inhibits bacterial drug resistance
文献类型：期刊论文
| 作者 | Xu, Zhiqiang1; Liu, Min2,3; Zhao, Na1; Chen, Guocai1; Lu, Weicheng4; Li, Haixin1; Wu, Yuanyan1; Tan, Hao1; Yang, Chunguang2; Zhang, Xinrui2 |
| 刊名 | MATERIALS LETTERS
 |
| 出版日期 | 2025-01-15 |
| 卷号 | 379页码:4 |
| 关键词 | Adhesion Biomaterials Metals and alloys Implant-associated infections Ti-Cu alloy Antibiotics |
| ISSN号 | 0167-577X |
| DOI | 10.1016/j.matlet.2024.137736 |
| 通讯作者 | Zhang, Xinrui(xrzhang16s@imr.ac.cn) |
| 英文摘要 | Implant-associated infection is mainly conducted with antibiotics in clinic. However, the overuse and abuse of antibiotics contributes to resistant infections, increasing the difficulty of treatment. In this work, we initially investigate the effect of anti-infective Ti-Cu alloy incorporating with antibiotics (ciprofloxacin) to inhibit methicillin-resistant Staphylococcus aureus (MRSA) infections. Results show that, for Drug + Ti-Cu alloy group, the minimum inhibitory concentration (MIC) of antibiotics reduces by 76.00 %, minimum bactericidal concentration (MBC) reduces by 75.00 % and IC50 reduces by 77.77 %. Scanning electron microscope (SEM) and laser confocal scanning microscope (CLSM) observations demonstrate that Ti-Cu alloy inhibits biofilms, including inhibiting bacterial activity and extracellular polymer substrates (EPS) secretion. We conclude high redox oxygen species (ROS) expression contributes to the excellent anti-infection capabilities of Ti-Cu alloy. Our work opens an avenue for addressing persistent drug resistant bacterial infections. |
| 资助项目 | Hospital of Traditional Chinese Medicine[202000206] ; National Natural Science Foundation of China[52301307] ; National Natural Science Foundation of China[52171242] ; Natural Science Foundation of Liaoning Province[2024-BSBA-48] ; Natural Science Foundation of Medical and Industrial Cross Joint of Liaoning Province[2022-YGJC-49] |
| WOS研究方向 | Materials Science ; Physics |
| 语种 | 英语 |
| WOS记录号 | WOS:001361137700001 |
| 出版者 | ELSEVIER |
| 资助机构 | Hospital of Traditional Chinese Medicine ; National Natural Science Foundation of China ; Natural Science Foundation of Liaoning Province ; Natural Science Foundation of Medical and Industrial Cross Joint of Liaoning Province |
| 源URL |  |
| 专题 | 金属研究所_中国科学院金属研究所 |
| 通讯作者 | Zhang, Xinrui |
| 作者单位 | 1.Foshan Hosp Tradit Chinese Med, Inst Orthoped & Traumatol, Foshan 528000, Peoples R China 2.Chinese Acad Sci, Inst Met Res, Shenyang 110016, Peoples R China 3.Univ Sci & Technol China, Sch Mat Sci & Engn, Shenyang 110016, Peoples R China 4.China Med Univ, Dept Neurosurg, Affiliated Hosp 1, Shenyang, Liaoning, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xu, Zhiqiang,Liu, Min,Zhao, Na,et al. Anti-infective Ti-Cu alloy inhibits bacterial drug resistance[J]. MATERIALS LETTERS,2025,379:4. |
| APA | Xu, Zhiqiang.,Liu, Min.,Zhao, Na.,Chen, Guocai.,Lu, Weicheng.,...&Zhang, Xinrui.(2025).Anti-infective Ti-Cu alloy inhibits bacterial drug resistance.MATERIALS LETTERS,379,4. |
| MLA | Xu, Zhiqiang,et al."Anti-infective Ti-Cu alloy inhibits bacterial drug resistance".MATERIALS LETTERS 379(2025):4. |
入库方式： OAI收割
来源：金属研究所
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