NIR-triggering cobalt single-atom enzyme switches off-to-on for boosting the interactive dynamic effects of multimodal phototherapy
文献类型：期刊论文
| 作者 | Dai, Hao1,2,3,4,5,6,7; Han, Ali8,9; Wang, Xijun10; Zhu, Peng8; Wang, Dingsheng8; Wang, Yuguang1 |
| 刊名 | NATURE COMMUNICATIONS
 |
| 出版日期 | 2025-02-28 |
| 卷号 | 16期号:1页码:17 |
| DOI | 10.1038/s41467-025-57188-9 |
| 通讯作者 | Han, Ali(hanali@mail.ustc.edu.cn) ; Wang, Dingsheng(wangdingsheng@mail.tsinghua.edu.cn) ; Wang, Yuguang(wangyuguang@bjmu.edu.cn) |
| 英文摘要 | Noninvasive phototherapy with functional preservation is considered to be a promising cancer therapeutic method. However, the clinical application of tumor phototherapy is severely restrained by the lack of appropriate multimodal phototherapy agents exhibiting an ideal tissue penetration depth to maximize the antitumor efficiency as well as to maintain important tissue functions. Herein, an innovative near-infrared ray (NIR)-triggered photodynamic-photocatalytic-photothermal therapy (PDT-PCT-PTT) agent based on an atomically dispersed cobalt single-atom enzyme (Co-SAE) anchored on hollow N-doped carbon sphere (HNCS) has been strategically developed. Reactive oxygen species (ROS) are highly activated and amplified through both the photogenerated electrons and the photothermal conversion induced by NIR irradiation, as systematically demonstrated by the experimental and density functional theory (DFT) calculation results. Mild hyperthermia is eventually achieved through apoptosis and ferroptosis caused by ROS, significantly boosting the interaction of ROS dynamic effects and thermodynamic effects in the tumor microenvironment (TME). More importantly, Co-SAEs/HNCS not only causes multimodal damage through limited TME products but also preserves important organ functions by the induction of mild local hyperthermia. This work expands the biomedical application field of SAEs and presents an innovative all-in-one, multimodal concept for the noninvasive treatment of head and neck cancer. |
| 资助项目 | National Science Foundation of China | National Natural Science Foundation of China-Yunnan Joint Fund (NSFC-Yunnan Joint Fund)[22202214-A] ; National Science Foundation of China | National Natural Science Foundation of China-Yunnan Joint Fund (NSFC-Yunnan Joint Fund)[22171157-D] ; National Natural Science Foundation of China[2022-YQ-02-A] ; Natural Science Foundation of Liaoning Province-Outstanding Youth Foundation |
| WOS研究方向 | Science & Technology - Other Topics |
| 语种 | 英语 |
| WOS记录号 | WOS:001435592900023 |
| 出版者 | NATURE PORTFOLIO |
| 资助机构 | National Science Foundation of China | National Natural Science Foundation of China-Yunnan Joint Fund (NSFC-Yunnan Joint Fund) ; National Natural Science Foundation of China ; Natural Science Foundation of Liaoning Province-Outstanding Youth Foundation |
| 源URL |  |
| 专题 | 金属研究所_中国科学院金属研究所 |
| 通讯作者 | Han, Ali; Wang, Dingsheng; Wang, Yuguang |
| 作者单位 | 1.Peking Univ Sch & Hosp, Peking Univ Sch & Hosp Stomatol, Dept Gen Dent 2, Beijing, Peoples R China 2.Peking Univ Sch & Hosp, Natl Ctr Stomatol, Beijing, Peoples R China 3.Peking Univ Sch & Hosp, Natl Clin Res Ctr Oral Dis, Beijing, Peoples R China 4.Peking Univ Sch & Hosp, Beijing Key Lab Digital Stomatol, Natl Engn Res Ctr Oral Biomat & Digital Med Device, Beijing, Peoples R China 5.Peking Univ Sch & Hosp, NHC Key Lab Digital Stomatol, Beijing, Peoples R China 6.Peking Univ Sch & Hosp, NMPA Key Lab Dent Mat, Beijing, Peoples R China 7.Peking Univ Sch & Hosp, Cent Lab, Beijing, Peoples R China 8.Tsinghua Univ, Dept Chem, Beijing, Peoples R China 9.Chinese Acad Sci, Inst Met Res, Shenyang Natl Lab Mat Sci, 72 Wenhua Rd, Shenyang, Peoples R China 10.Northwestern Univ, Dept Chem & Biol Engn, 2145 Sheridan Rd, Evanston, IL USA |
| 推荐引用方式 GB/T 7714 | Dai, Hao,Han, Ali,Wang, Xijun,et al. NIR-triggering cobalt single-atom enzyme switches off-to-on for boosting the interactive dynamic effects of multimodal phototherapy[J]. NATURE COMMUNICATIONS,2025,16(1):17. |
| APA | Dai, Hao,Han, Ali,Wang, Xijun,Zhu, Peng,Wang, Dingsheng,&Wang, Yuguang.(2025).NIR-triggering cobalt single-atom enzyme switches off-to-on for boosting the interactive dynamic effects of multimodal phototherapy.NATURE COMMUNICATIONS,16(1),17. |
| MLA | Dai, Hao,et al."NIR-triggering cobalt single-atom enzyme switches off-to-on for boosting the interactive dynamic effects of multimodal phototherapy".NATURE COMMUNICATIONS 16.1(2025):17. |
入库方式： OAI收割
来源：金属研究所
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