Lipidomic alterations in oysters caused by environmentally relevant exposure to microplastics and estrogenic endocrine disrupting chemicals
文献类型：期刊论文
| 作者 | Kumar, Sazal7; O'connor, Wayne6; Melvin, Steven D.5; Leusch, Frederic D. L.5; Luengen, Allison C.4; Islam, Rafiquel3,7; Ji, Chenglong2,7; Zhan, Junfei1,7; Macfarlane, Geoff R.7 |
| 刊名 | ECOTOXICOLOGY
 |
| 出版日期 | 2026-02-28 |
| 卷号 | 35期号:4页码:14 |
| 关键词 | Oxidative stress Microplastics Estrogens Molluscs Adaptive response Estradiol |
| ISSN号 | 0963-9292 |
| DOI | 10.1007/s10646-026-03055-2 |
| 通讯作者 | Macfarlane, Geoff R.(geoff.macfarlane@newcastle.edu.au) |
| 英文摘要 | There is a ubiquitous co-occurrence of microplastics (MPs) and estrogenic endocrine disrupting chemicals (EEDCs) in aquatic environments. Their combined presence may induce sub-lethal stress in aquatic organisms, like molluscs, which may adapt to the stress through adjusting the lipidome. This study explored the individual and combined effects of polyethylene microplastics (PE-MPs) and a mixture of EEDCs at environmentally realistic concentrations on the lipidome of the Sydney rock oyster (Saccostrea glomerata). After seven days exposure, lipids were measured in the digestive glands and gonads using proton nuclear magnetic resonance (H-1 NMR) spectroscopy. Permutational analysis of variance (PERMANOVA) revealed the lipidome of oysters exhibited treatment differences with interactions between sex and tissue type. Subsequent post-hoc analysis revealed the male digestive gland to be significantly more responsive than the other tissues tested. An increase in cholesterols and aldehydes in all treatments compared to controls was ascribed to an adaptive response to transient oxidative stress in oysters, which was alleviated by increased food intake. There was a significantly greater effect of the EEDCs mixture than PE-MPs in oysters. The combined oxidative stress of PE-MPs and EEDCs from co-exposure did not exceed the individual effects of PE-MPs and EEDCs, which may relate to low exposure concentrations of PE-MPs, selective rejection of MPs in pseudofeces, or poor vector role of smooth surfaced PE-MPs. |
| WOS关键词 | SYDNEY ROCK OYSTER ; SACCOSTREA-GLOMERATA ; STEROL BIOSYNTHESIS ; OXIDATIVE STRESS ; VITELLOGENIN ; MUSSEL ; COEXPOSURE ; INDUCTION ; BIOMARKER ; TOXICITY |
| WOS研究方向 | Environmental Sciences & Ecology ; Toxicology |
| 语种 | 英语 |
| WOS记录号 | WOS:001703502400007 |
| 资助机构 | The University of Newcastle (Australia) |
| 源URL | [http://ir.yic.ac.cn/handle/133337/42225]  |
| 专题 | 烟台海岸带研究所_中科院海岸带环境过程与生态修复重点实验室 |
| 通讯作者 | Macfarlane, Geoff R. |
| 作者单位 | 1.Ludong Univ, Inst Adv Study Coastal Ecol, Key Lab Ecol Restorat & Conservat Coastal Wetlands, Yantai 264025, Peoples R China 2.Chinese Acad Sci, Yantai Inst Coastal Zone Res YIC, Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China 3.Islamic Univ, Dept Appl Chem & Chem Engn, Kustia 7003, Bangladesh 4.Univ San Francisco, Dept Environm Sci, San Francisco, CA 94117 USA 5.Griffith Univ, Australian Rivers Inst, Sch Environm & Sci, Southport, Qld 4222, Australia 6.Port Stephens Fisheries Inst, Dept Primary Ind & Rural Dev, Taylors Beach, NSW 2316, Australia 7.Univ Newcastle UoN, Sch Environm & Life Sci, Callaghan, NSW 2308, Australia |
| 推荐引用方式 GB/T 7714 | Kumar, Sazal,O'connor, Wayne,Melvin, Steven D.,et al. Lipidomic alterations in oysters caused by environmentally relevant exposure to microplastics and estrogenic endocrine disrupting chemicals[J]. ECOTOXICOLOGY,2026,35(4):14. |
| APA | Kumar, Sazal.,O'connor, Wayne.,Melvin, Steven D..,Leusch, Frederic D. L..,Luengen, Allison C..,...&Macfarlane, Geoff R..(2026).Lipidomic alterations in oysters caused by environmentally relevant exposure to microplastics and estrogenic endocrine disrupting chemicals.ECOTOXICOLOGY,35(4),14. |
| MLA | Kumar, Sazal,et al."Lipidomic alterations in oysters caused by environmentally relevant exposure to microplastics and estrogenic endocrine disrupting chemicals".ECOTOXICOLOGY 35.4(2026):14. |
入库方式： OAI收割
来源：烟台海岸带研究所
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