Broad synergistic effects of an AMP with multiple antibiotics against drug-resistant bacteria via multifaceted mechanisms
文献类型：期刊论文
| 作者 | Ye, Zifan4,5; Wang, Xia4; Xu, Zhouye4; Wang, Taizhong2; Wang, Juan1,5; Li, Shuangyu4,5; Kong, Xiangjin3,5; Zhang, Jingjing3,5; Jiao, Xudong3,5; Fu, Lei2 |
| 刊名 | SCIENCE CHINA-LIFE SCIENCES
 |
| 出版日期 | 2026-03-04 |
| 页码 | 22 |
| 关键词 | antimicrobial peptide antibiotic adjuvant multidrug-resistant bacteria efflux pump inhibition biofilm eradication |
| ISSN号 | 1674-7305 |
| DOI | 10.1007/s11427-025-3175-9 |
| 通讯作者 | Fu, Lei(leifu@mail.bnu.edu.cn) ; Wang, Yipeng(ypwang@yic.ac.cn) |
| 英文摘要 | Antimicrobial peptides (AMPs) have emerged as promising alternatives or adjuncts to antibiotics. However, most studies on AMP-antibiotic combinations focus on specific drugs or pathogens, with limited exploration of broad-spectrum synergistic effects. Herein, we demonstrate that CATHPb1, a snake-derived AMP, exhibits extensive synergistic antimicrobial activity when combined with 12 antibiotics representing six distinct mechanisms of action. Moreover, CATHPb1 shows a low potential for inducing resistance and significantly enhances anti-biofilm and anti-persister activities in combination with antibiotics. The broad-spectrum synergy of CATHPb1 can be attributed to multiple mechanisms-including specific efflux pump inhibition, ROS generation, cell wall disruption, and DNA binding-distinct from the commonly observed membrane-disrupting activity. Notably, CATHPb1 markedly enhanced antibiotic efficacy in murine models of peritonitis and bacteremia, resulting in reduced bacterial loads of multidrug-resistant bacteria, decreased inflammatory responses, and improved survival rates. These findings underscore the therapeutic potential of CATHPb1 as a versatile adjuvant for combating multidrug-resistant bacterial infections. |
| WOS关键词 | PARTICLE MESH EWALD ; IN-VITRO SYNERGY ; ANTIMICROBIAL PEPTIDE ; CATHELICIDIN ; INFECTIONS ; EFFICACY ; POLYMYXINS ; TOLERANCE ; SURVIVAL ; ACID |
| WOS研究方向 | Life Sciences & Biomedicine - Other Topics |
| 语种 | 英语 |
| WOS记录号 | WOS:001711229900001 |
| 资助机构 | National Natural Science Foundation of China ; Key Research & Development Plan in Social Development of Jiangsu Province |
| 源URL | [http://ir.yic.ac.cn/handle/133337/42249]  |
| 专题 | 海岸带生物学与生物资源利用重点实验室 |
| 通讯作者 | Fu, Lei; Wang, Yipeng |
| 作者单位 | 1.Shandong Univ Tradit Chinese Med, Qingdao Acad Chinese Med Sci, Res Inst Marine Tradit Chinese Med, Qingdao 266112, Peoples R China 2.Shenzhen Univ, South China Hosp, Inst Med Artificial Intelligence, Med Sch, Shenzhen 518116, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Soochow Univ, Coll Pharmaceut Sci, Dept Biopharmaceut Sci, Suzhou 215123, Peoples R China 5.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ye, Zifan,Wang, Xia,Xu, Zhouye,et al. Broad synergistic effects of an AMP with multiple antibiotics against drug-resistant bacteria via multifaceted mechanisms[J]. SCIENCE CHINA-LIFE SCIENCES,2026:22. |
| APA | Ye, Zifan.,Wang, Xia.,Xu, Zhouye.,Wang, Taizhong.,Wang, Juan.,...&Wang, Yipeng.(2026).Broad synergistic effects of an AMP with multiple antibiotics against drug-resistant bacteria via multifaceted mechanisms.SCIENCE CHINA-LIFE SCIENCES,22. |
| MLA | Ye, Zifan,et al."Broad synergistic effects of an AMP with multiple antibiotics against drug-resistant bacteria via multifaceted mechanisms".SCIENCE CHINA-LIFE SCIENCES (2026):22. |
入库方式： OAI收割
来源：烟台海岸带研究所
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