中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 烟台海岸带研究所
  3. 中国科学院烟台海岸带研究所
  4. 海岸带生物学与生物资源利用重点实验室
Engineered alginate/pectin hydrogel beads co-delivery of phycocyanin and berberine for therapy of inflammatory bowel disease via alleviating inflammation and modulating microbiota

文献类型：期刊论文

作者Liu, Xiaoying5; Ding, Baoqi5; Zou, Yihan5; Liu, Haohang5; Liu, Keyan5; Qu, Wenxin5; Zhang, Renlong1; Yuan, Ye5; Tian, Weizhe5; Dai, Weihan5
刊名CHEMICAL ENGINEERING SCIENCE
出版日期2026-07-01
卷号329页码:14
关键词Inflammatory bowel disease Phycocyanin Berberine Inflammation amelioration Gut microbiota regulation
ISSN号0009-2509
DOI10.1016/j.ces.2026.123834
通讯作者Li, Wenjun(wjli@yic.ac.cn) ; Wang, Yuan(wangyuan02@novapathpharma.com) ; Ren, Chunguang(cgren@ytu.edu.cn) ; Zhang, Yu(zhangyu1994@pku.edu.cn)
英文摘要Inflammatory bowel disease (IBD), a chronic and relapsing disorder characterized by intestinal ulcers, edema, and bleeding, is profoundly influenced by bacterial infections and elevated reactive oxygen species (ROS) levels. To simultaneously address these dual pathological factors, we engineered a series of surfactant-modified alginate/pectin hydrogel beads for the co-delivery of phycocyanin and berberine. The incorporation of surfactants not only tailored the morphological properties and drug release profiles but also achieved substantially improved encapsulation efficiency and drug loading. The hydrogel beads exhibited distinct pH-responsive drug release and effective antibacterial activity against E. coli and S. aureus, which also displayed excellent antioxidant capacity and biocompatibility. In vivo evaluation in a DSS-induced mice colitis model revealed that BPC@SDS beads treatment mitigated colon shortening and alleviated histopathological damage. Furthermore, it restored intestinal microbiota homeostasis, demonstrating its potential as an effective intestinal-targeted therapy for IBD, providing a novel strategy that addresses both inflammation and dysbiosis.
WOS关键词NANOPARTICLES ; FABRICATION ; SURFACTANT ; STABILITY ; COLITIS ; DAMAGE
WOS研究方向Engineering
语种英语
WOS记录号WOS:001728670000001
资助机构Yantai University Start-up Foundation ; Yantai Science and Technology Innovation Development Program
源URL[http://ir.yic.ac.cn/handle/133337/42326]  
专题海岸带生物学与生物资源利用重点实验室
通讯作者Li, Wenjun; Wang, Yuan; Ren, Chunguang; Zhang, Yu
作者单位1.Shandong Univ, Sch Basic Med Sci, Jinan 250012, Shandong, Peoples R China
2.Novapath Med Device Technol Yantai Co Ltd, Yantai 264000, Peoples R China
3.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Shandong, Peoples R China
4.Yantai Univ, Sch Life Sci, Yantai Key Lab Characterist Agr Bioresource Conser, Yantai 264000, Peoples R China
5.Yantai Univ, Sch Pharm, Yantai 264005, Shandong, Peoples R China
推荐引用方式
GB/T 7714		 Liu, Xiaoying,Ding, Baoqi,Zou, Yihan,et al. Engineered alginate/pectin hydrogel beads co-delivery of phycocyanin and berberine for therapy of inflammatory bowel disease via alleviating inflammation and modulating microbiota[J]. CHEMICAL ENGINEERING SCIENCE,2026,329:14.
APA Liu, Xiaoying.,Ding, Baoqi.,Zou, Yihan.,Liu, Haohang.,Liu, Keyan.,...&Zhang, Yu.(2026).Engineered alginate/pectin hydrogel beads co-delivery of phycocyanin and berberine for therapy of inflammatory bowel disease via alleviating inflammation and modulating microbiota.CHEMICAL ENGINEERING SCIENCE,329,14.
MLA Liu, Xiaoying,et al."Engineered alginate/pectin hydrogel beads co-delivery of phycocyanin and berberine for therapy of inflammatory bowel disease via alleviating inflammation and modulating microbiota".CHEMICAL ENGINEERING SCIENCE 329(2026):14.

入库方式： OAI收割

来源：烟台海岸带研究所

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。