Tuna Oil Attenuates Crab Tropomyosin-Induced Food Allergy in Mice via Modulation of Intestinal Immunity, Microbiota, and Proteome
文献类型：期刊论文
| 作者 | Ji, Xueke5,6; Zhong, Yuzhen5,6; Wang, Yanxin3,4,5,6; Xie, Mengen5,6; Liu, Qingmei2; Li, Wenjun1; Zhang, Xing5,6; Lu, Chenyang5,6 |
| 刊名 | JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
 |
| 出版日期 | 2026-04-22 |
| 卷号 | 74期号:15页码:12216-12228 |
| 关键词 | tuna oil crab tropomyosin food allergy intestinal immunity gut microbiota colonicproteome |
| ISSN号 | 0021-8561 |
| DOI | 10.1021/acs.jafc.6c02244 |
| 通讯作者 | Lu, Chenyang(luchenyang@nbu.edu.cn) |
| 英文摘要 | Food allergies, particularly to crustaceans, are a growing health concern with limited management options. We heterologously expressed and purified crab tropomyosin and then evaluated the beneficial effects of tuna oil on crab TM-induced food allergy in mice. The results demonstrated that tuna oil dose-dependently alleviated allergic symptoms and reduced serum levels of TM-specific IgE, histamine, and cytokines. It also improved intestinal dendritic cell imbalance by reducing CD11c+CD80+/CD86+ cells and restoring CD103+ subsets. In addition, tuna oil enhanced the richness and diversity of gut microbiota, increased beneficial Ligilactobacillus, and decreased allergy-associated taxa. Proteomics further revealed that tuna oil partially reversed TM-induced colonic proteomic alterations, including the downregulation of Tpsab1 and the modulation of lipid metabolism pathways. In conclusion, tuna oil alleviates crab TM-induced allergy through integrated regulation of intestinal immunity, gut microbiota, and colonic proteome, supporting its potential as a dietary strategy against crustacean allergy. |
| WOS关键词 | OMEGA-3-FATTY-ACIDS ; PREVENTION |
| WOS研究方向 | Agriculture ; Chemistry ; Food Science & Technology |
| 语种 | 英语 |
| WOS记录号 | WOS:001740402600001 |
| 资助机构 | K. C. Wong Magna Fund in Ningbo University ; Key Research and Development Program of Ningbo city ; Marine Industry Science and Technology Project of Zhejiang Province ; National Natural Science Foundation of China |
| 源URL | [http://ir.yic.ac.cn/handle/133337/42381]  |
| 专题 | 海岸带生物学与生物资源利用重点实验室 |
| 通讯作者 | Lu, Chenyang |
| 作者单位 | 1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China 2.Jimei Univ, Coll Ocean Food & Biol Engn, Xiamen 361021, Peoples R China 3.China Univ Petr East China, Ctr Bioengn & Biotechnol, Qingdao 266580, Peoples R China 4.China Univ Petr East China, State Key Lab Heavy Oil Proc, Qingdao 266580, Peoples R China 5.Ningbo Univ, Inst Drug Discovery Technol, Ningbo 315211, Peoples R China 6.Ningbo Univ, Sch Marine Sci, State Key Lab Qual & Safety Agroprod, Ningbo 315211, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ji, Xueke,Zhong, Yuzhen,Wang, Yanxin,et al. Tuna Oil Attenuates Crab Tropomyosin-Induced Food Allergy in Mice via Modulation of Intestinal Immunity, Microbiota, and Proteome[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2026,74(15):12216-12228. |
| APA | Ji, Xueke.,Zhong, Yuzhen.,Wang, Yanxin.,Xie, Mengen.,Liu, Qingmei.,...&Lu, Chenyang.(2026).Tuna Oil Attenuates Crab Tropomyosin-Induced Food Allergy in Mice via Modulation of Intestinal Immunity, Microbiota, and Proteome.JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,74(15),12216-12228. |
| MLA | Ji, Xueke,et al."Tuna Oil Attenuates Crab Tropomyosin-Induced Food Allergy in Mice via Modulation of Intestinal Immunity, Microbiota, and Proteome".JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 74.15(2026):12216-12228. |
入库方式： OAI收割
来源：烟台海岸带研究所
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