beta CaMKII in Lateral Habenula Mediates Core Symptoms of Depression
文献类型：期刊论文
| 作者 | Li, K ; Zhou, T ; Liao, LJ ; Yang, ZF ; Wong, C ; Henn, F ; Malinow, R ; Yates, JR ; Hu, HL |
| 刊名 | SCIENCE
 |
| 出版日期 | 2013 |
| 卷号 | 341期号:6149页码:1016-1020 |
| 关键词 | DEPENDENT-PROTEIN-KINASE VENTRAL TEGMENTAL AREA MAJOR DEPRESSION BASAL GANGLIA STRESS NEURONS MODEL NEUROTOXICITY HIPPOCAMPUS ACTIVATION |
| ISSN号 | 0036-8075 |
| 通讯作者 | Hu, HL (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, Shanghai 200031, Peoples R China.,hailan@ion.ac.cn |
| 英文摘要 | The lateral habenula (LHb) has recently emerged as a key brain region in the pathophysiology of depression. However, the molecular mechanism by which LHb becomes hyperactive in depression remains unknown. Through a quantitative proteomic screen, we found that expression of the beta form of calcium/calmodulin-dependent protein kinase type II (beta CaMKII) was significantly up-regulated in the LHb of animal models of depression and down-regulated by antidepressants. Increasing beta-, but not alpha-, CaMKII in the LHb strongly enhanced the synaptic efficacy and spike output of LHb neurons and was sufficient to produce profound depressive symptoms, including anhedonia and behavioral despair. Down-regulation of beta CaMKII levels, blocking its activity or its target molecule the glutamate receptor GluR1 reversed the depressive symptoms. These results identify beta CaMKII as a powerful regulator of LHb neuron function and a key molecular determinant of depression. |
| 学科主题 | Science & Technology - Other Topics |
| 收录类别 | SCI |
| 资助信息 | Chinese 973 Program [2011CBA00400]; Strategic Priority Research Program (B) of the Chinese Academy of Sciences [XDB02030004]; Hundreds of Talents Program; Outstanding Youth Grant; Shanghai Pujiang Talent Program; NIH [P41 GM103533, R01 MH067880]; Simon's Foundation |
| 语种 | 英语 |
| 公开日期 | 2013-11-06 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/2562]  |
| 专题 | 上海神经科学研究所_神经所(总) |
| 推荐引用方式 GB/T 7714 | Li, K,Zhou, T,Liao, LJ,et al. beta CaMKII in Lateral Habenula Mediates Core Symptoms of Depression[J]. SCIENCE,2013,341(6149):1016-1020. |
| APA | Li, K.,Zhou, T.,Liao, LJ.,Yang, ZF.,Wong, C.,...&Hu, HL.(2013).beta CaMKII in Lateral Habenula Mediates Core Symptoms of Depression.SCIENCE,341(6149),1016-1020. |
| MLA | Li, K,et al."beta CaMKII in Lateral Habenula Mediates Core Symptoms of Depression".SCIENCE 341.6149(2013):1016-1020. |
入库方式： OAI收割
来源：上海神经科学研究所
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