Axon position within the corpus callosum determines contralateral cortical projection
文献类型：期刊论文
| 作者 | Zhou, J ; Wen, YQ ; She, L ; Sui, YN ; Liu, L ; Richards, LJ ; Poo, MM |
| 刊名 | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
 |
| 出版日期 | 2013 |
| 卷号 | 110期号:29页码:E2714-E2723 |
| 关键词 | SOMATOSENSORY CORTEX MAMMALIAN FOREBRAIN AUDITORY-CORTEX NERVOUS-SYSTEM EPH RECEPTORS GUIDANCE TOPOGRAPHY NEURONS GROWTH CONNECTIONS |
| ISSN号 | 0027-8424 |
| 通讯作者 | Poo, MM (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, State Key Lab Neurosci, Shanghai 200031, Peoples R China.,mpoo@berkeley.edu |
| 英文摘要 | How developing axons in the corpus callosum (CC) achieve their homotopic projection to the contralateral cortex remains unclear. We found that axonal position within the CC plays a critical role in this projection. Labeling of nearby callosal axons in mice showed that callosal axons were segregated in an orderly fashion, with those from more medial cerebral cortex located more dorsally and subsequently projecting to more medial contralateral cortical regions. The normal axonal order within the CC was grossly disturbed when semaphorin3A/neuropilin-1 signaling was disrupted. However, the order in which axons were positioned within the CC still determined their contralateral projection, causing a severe disruption of the homotopic contralateral projection that persisted at postnatal day 30, when the normal developmental refinement of contralateral projections is completed in wild-type (WT) mice. Thus, the orderly positioning of axons within the CC is a primary determinant of how homotopic interhemispheric projections form in the contralateral cortex. |
| 学科主题 | Science & Technology - Other Topics |
| 收录类别 | SCI |
| 资助信息 | 973 Program [2011CBA00400]; Strategic Priority Research Program of the Chinese Academy of Sciences [XDB02020001]; Principal Research Fellowship from the National Health and Medical Research Council, Australia |
| 语种 | 英语 |
| 公开日期 | 2013-11-06 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/2564]  |
| 专题 | 上海神经科学研究所_神经所(总) |
| 推荐引用方式 GB/T 7714 | Zhou, J,Wen, YQ,She, L,et al. Axon position within the corpus callosum determines contralateral cortical projection[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2013,110(29):E2714-E2723. |
| APA | Zhou, J.,Wen, YQ.,She, L.,Sui, YN.,Liu, L.,...&Poo, MM.(2013).Axon position within the corpus callosum determines contralateral cortical projection.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,110(29),E2714-E2723. |
| MLA | Zhou, J,et al."Axon position within the corpus callosum determines contralateral cortical projection".PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 110.29(2013):E2714-E2723. |
入库方式： OAI收割
来源：上海神经科学研究所
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