中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Canonical transient receptor potential 3 channels regulate mitochondrial calcium uptake

文献类型:期刊论文

作者Feng, SJ ; Li, HY ; Tai, YL ; Huang, JB ; Su, YJ ; Abramowitz, J ; Zhu, MX ; Birnbaumer, L ; Wang, YZ
刊名PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
出版日期2013
卷号110期号:27页码:11011-11016
关键词TRP CHANNELS ESSENTIAL COMPONENT RELEASE CHANNEL CATION CHANNEL CA2+ UNIPORTER PROTEIN TRPML1 MEMBRANE OSCILLATIONS PROPAGATION MECHANISMS
ISSN号0027-8424
通讯作者Birnbaumer, L (reprint author), NIEHS, Neurobiol Lab, POB 12233, Res Triangle Pk, NC 27709 USA.,birnbau1@niehs.nih.gov ; yzwang@ion.ac.cn
英文摘要Mitochondrial Ca2+ homeostasis is fundamental to regulation of mitochondrial membrane potential, ATP production, and cellular Ca2+ homeostasis. It has been known for decades that isolated mitochondria can take up Ca2+ from the extramitochondrial solution, but the molecular identity of the Ca2+ channels involved in this action is largely unknown. Here, we show that a fraction of canonical transient receptor potential 3 (TRPC3) channels is localized to mitochondria, a significant fraction of mitochondrial Ca2+ uptake that relies on extramitochondrial Ca2+ concentration is TRPC3-dependent, and the up-and down-regulation of TRPC3 expression in the cell influences the mitochondrial membrane potential. Our findings suggest that TRPC3 channels contribute to mitochondrial Ca2+ uptake. We anticipate our observations may provide insights into the mechanisms of mitochondrial Ca2+ uptake and advance understanding of the physiological role of TRPC3.
学科主题Science & Technology - Other Topics
收录类别SCI
资助信息National Neural Science Foundation of China (NNSF) [81130081]; 973 program [2011CBA00400]; National Institutes of Health (NIH) [Z01-ES-101684, R01 GM081658]
语种英语
公开日期2013-11-06
源URL[http://ir.sibs.ac.cn/handle/331001/2565]  
专题上海神经科学研究所_神经所(总)
推荐引用方式
GB/T 7714
Feng, SJ,Li, HY,Tai, YL,et al. Canonical transient receptor potential 3 channels regulate mitochondrial calcium uptake[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2013,110(27):11011-11016.
APA Feng, SJ.,Li, HY.,Tai, YL.,Huang, JB.,Su, YJ.,...&Wang, YZ.(2013).Canonical transient receptor potential 3 channels regulate mitochondrial calcium uptake.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,110(27),11011-11016.
MLA Feng, SJ,et al."Canonical transient receptor potential 3 channels regulate mitochondrial calcium uptake".PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 110.27(2013):11011-11016.

入库方式: OAI收割

来源:上海神经科学研究所

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