Canonical transient receptor potential 3 channels regulate mitochondrial calcium uptake
文献类型:期刊论文
作者 | Feng, SJ ; Li, HY ; Tai, YL ; Huang, JB ; Su, YJ ; Abramowitz, J ; Zhu, MX ; Birnbaumer, L ; Wang, YZ |
刊名 | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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出版日期 | 2013 |
卷号 | 110期号:27页码:11011-11016 |
关键词 | TRP CHANNELS ESSENTIAL COMPONENT RELEASE CHANNEL CATION CHANNEL CA2+ UNIPORTER PROTEIN TRPML1 MEMBRANE OSCILLATIONS PROPAGATION MECHANISMS |
ISSN号 | 0027-8424 |
通讯作者 | Birnbaumer, L (reprint author), NIEHS, Neurobiol Lab, POB 12233, Res Triangle Pk, NC 27709 USA.,birnbau1@niehs.nih.gov ; yzwang@ion.ac.cn |
英文摘要 | Mitochondrial Ca2+ homeostasis is fundamental to regulation of mitochondrial membrane potential, ATP production, and cellular Ca2+ homeostasis. It has been known for decades that isolated mitochondria can take up Ca2+ from the extramitochondrial solution, but the molecular identity of the Ca2+ channels involved in this action is largely unknown. Here, we show that a fraction of canonical transient receptor potential 3 (TRPC3) channels is localized to mitochondria, a significant fraction of mitochondrial Ca2+ uptake that relies on extramitochondrial Ca2+ concentration is TRPC3-dependent, and the up-and down-regulation of TRPC3 expression in the cell influences the mitochondrial membrane potential. Our findings suggest that TRPC3 channels contribute to mitochondrial Ca2+ uptake. We anticipate our observations may provide insights into the mechanisms of mitochondrial Ca2+ uptake and advance understanding of the physiological role of TRPC3. |
学科主题 | Science & Technology - Other Topics |
收录类别 | SCI |
资助信息 | National Neural Science Foundation of China (NNSF) [81130081]; 973 program [2011CBA00400]; National Institutes of Health (NIH) [Z01-ES-101684, R01 GM081658] |
语种 | 英语 |
公开日期 | 2013-11-06 |
源URL | [http://ir.sibs.ac.cn/handle/331001/2565] ![]() |
专题 | 上海神经科学研究所_神经所(总) |
推荐引用方式 GB/T 7714 | Feng, SJ,Li, HY,Tai, YL,et al. Canonical transient receptor potential 3 channels regulate mitochondrial calcium uptake[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2013,110(27):11011-11016. |
APA | Feng, SJ.,Li, HY.,Tai, YL.,Huang, JB.,Su, YJ.,...&Wang, YZ.(2013).Canonical transient receptor potential 3 channels regulate mitochondrial calcium uptake.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,110(27),11011-11016. |
MLA | Feng, SJ,et al."Canonical transient receptor potential 3 channels regulate mitochondrial calcium uptake".PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 110.27(2013):11011-11016. |
入库方式: OAI收割
来源:上海神经科学研究所
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