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The Epigenetic Switches for Neural Development and Psychiatric Disorders
文献类型：期刊论文
| 作者 | Lv, JW ; Xin, YJ ; Zhou, WH ; Qiu, ZL |
| 刊名 | JOURNAL OF GENETICS AND GENOMICS
 |
| 出版日期 | 2013 |
| 卷号 | 40期号:7页码:339-346 |
| 关键词 | REGULATES MEMORY FORMATION ACTIVE DNA DEMETHYLATION RETT-SYNDROME ADULT NEUROGENESIS GENE-EXPRESSION MOUSE MODEL SYNAPTIC PLASTICITY BDNF TRANSCRIPTION DENDRITIC GROWTH VISUAL-CORTEX |
| ISSN号 | 1673-8527 |
| 通讯作者 | Zhou, WH (reprint author), Fudan Univ, Childrens Hosp, Dept Neonatol, Shanghai 201102, Peoples R China.,zhou_wenhao@yahoo.com.cn ; zqiu@ion.ac.cn |
| 英文摘要 | The most remarkable feature of the nervous system is that the development and functions of the brain are largely reshaped by postnatal experiences, in joint with genetic landscapes. The nature vs. nurture argument reminds us that both genetic and epigenetic information is indispensable for the normal function of the brain. The epigenetic regulatory mechanisms in the central nervous system have been revealed over last a decade. Moreover, the mutations of epigenetic modulator genes have been shown to be implicated in neuropsychiatric disorders, such as autism spectrum disorders. The epigenetic study has initiated in the neuroscience field for a relative short period of time. In this review, we will summarize recent discoveries about epigenetic regulation on neural development, synaptic plasticity, learning and memory, as well as neuropsychiatric disorders. Although the comprehensive view of how epigenetic regulation contributes to the function of the brain is still not completed, the notion that brain, the most complicated organ of organisms, is profoundly shaped by epigenetic switches is widely accepted. |
| 学科主题 | Biochemistry & Molecular Biology ; Genetics & Heredity |
| 收录类别 | SCI |
| 资助信息 | National Natural Science Foundation of China (the Fostering Project of the Major Research) [91232712] |
| 语种 | 英语 |
| WOS记录号 | WOS:000322060600004 |
| 公开日期 | 2013-11-06 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/2566]  |
| 专题 | 上海神经科学研究所_神经所(总) |
| 推荐引用方式 GB/T 7714 | Lv, JW,Xin, YJ,Zhou, WH,et al. The Epigenetic Switches for Neural Development and Psychiatric Disorders[J]. JOURNAL OF GENETICS AND GENOMICS,2013,40(7):339-346. |
| APA | Lv, JW,Xin, YJ,Zhou, WH,&Qiu, ZL.(2013).The Epigenetic Switches for Neural Development and Psychiatric Disorders.JOURNAL OF GENETICS AND GENOMICS,40(7),339-346. |
| MLA | Lv, JW,et al."The Epigenetic Switches for Neural Development and Psychiatric Disorders".JOURNAL OF GENETICS AND GENOMICS 40.7(2013):339-346. |
入库方式： OAI收割
来源：上海神经科学研究所
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