NOMPC is likely a key component of Drosophila mechanotransduction channels
文献类型：期刊论文
| 作者 | Gong, JX ; Wang, QX ; Wang, ZR |
| 刊名 | EUROPEAN JOURNAL OF NEUROSCIENCE
 |
| 出版日期 | 2013 |
| 卷号 | 38期号:1页码:2057-2064 |
| 关键词 | TRP CHANNELS ANTENNAL LOBE MECHANOSENSORY TRANSDUCTION LOCAL INTERNEURONS HAIR-CELLS TOUCH MECHANISMS SUBUNIT NEURONS HEARING |
| ISSN号 | 0953-816X |
| 通讯作者 | Wang, ZR (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, State Key Lab Neurosci, Inst Neurosci, Shanghai, Peoples R China.,ZuorenWang@ion.ac.cn |
| 英文摘要 | Mechanotransduction is the basis of several sensory modalities, including touch, hearing, proprioception and gravity sensation. Despite its importance to sensory processing and behavior, the molecular mechanisms underlying mechanotransduction remain to be fully understood. In particular, the identity of the ion channels serving mechanotransduction is still unknown in many species. Drosophila melanogaster nompC (no mechanoreceptor potential C) has been shown to be essential for mechanotransduction in flies, yet there is no direct evidence demonstrating that NOMPC is indeed a mechanotransducing ion channel in Drosophila. To dissect the functional roles of NOMPC in mechanotransduction, we found that NOMPC-dependent transient adapting mechanoreceptor current (MRC) in the external bristle sensory organ was also chloride dependent. However, this chloride-dependent current was not necessary for spike generation. Furthermore, ectopic expression of wild-type NOMPC conferred mechanosensitivity on the interneurons in the antennal lobe (AL) and cation-mediated inward mechanocurrent was recorded, while a point mutation in the putative selective filter region of NOMPC failed to produce the mechanocurrent in the AL interneurons. These functional studies imply that NOMPC is likely to be a crucial component of mechanotransducers that accounts for mechanotransductions in mechanosensory neurons of Drosophila. |
| 学科主题 | Neurosciences & Neurology |
| 收录类别 | SCI |
| 资助信息 | Chinese Academy of Science [XDB02010500] |
| 语种 | 英语 |
| 公开日期 | 2013-11-06 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/2568]  |
| 专题 | 上海神经科学研究所_神经所(总) |
| 推荐引用方式 GB/T 7714 | Gong, JX,Wang, QX,Wang, ZR. NOMPC is likely a key component of Drosophila mechanotransduction channels[J]. EUROPEAN JOURNAL OF NEUROSCIENCE,2013,38(1):2057-2064. |
| APA | Gong, JX,Wang, QX,&Wang, ZR.(2013).NOMPC is likely a key component of Drosophila mechanotransduction channels.EUROPEAN JOURNAL OF NEUROSCIENCE,38(1),2057-2064. |
| MLA | Gong, JX,et al."NOMPC is likely a key component of Drosophila mechanotransduction channels".EUROPEAN JOURNAL OF NEUROSCIENCE 38.1(2013):2057-2064. |
入库方式： OAI收割
来源：上海神经科学研究所
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