Dopaminergic modulation of axonal potassium channels and action potential waveform in pyramidal neurons of prefrontal cortex
文献类型：期刊论文
| 作者 | Yang, J ; Ye, MY ; Tian, CP ; Yang, MP ; Wang, YH ; Shu, YS |
| 刊名 | JOURNAL OF PHYSIOLOGY-LONDON
 |
| 出版日期 | 2013 |
| 卷号 | 591期号:13页码:3233-3251 |
| ISSN号 | 0022-3751 |
| 关键词 | OUTSIDE-OUT PATCHES RECEPTOR MODULATION IN-VITRO NORADRENERGIC NEURONS CALCIUM-CHANNELS CORTICAL-NEURONS XENOPUS OOCYTES CEREBRAL-CORTEX PROTEIN-KINASE K+ CHANNELS |
| 通讯作者 | Shu, YS (reprint author), 320 Yueyang Rd, Shanghai 200031, Peoples R China.,shu@ion.ac.cn |
| 英文摘要 | Voltage-gated K+ (K-V) channels play critical roles in shaping neuronal signals. K-V channels distributed in the perisomatic regions and thick dendrites of cortical pyramidal neurons have been extensively studied. However, the properties and regulation of K-V channels distributed in the thin axons remain unknown. In this study, by performing somatic and axonal patch-clamp recordings from layer 5 pyramidal neurons of prefrontal cortical slices, we showed that the rapidly inactivating A-currents mediated the transient K+ currents evoked by action potential (AP) waveform command (K-AP) at the soma, whereas the rapidly activating but slowly inactivating K(V)1-mediated D-currents dominated the K-AP at the axon. In addition, activation of D1-like receptors for dopamine decreased the axonal K+ currents, as a result of an increase in the activity of cAMP-PKA pathway. In contrast, activation of D2-like receptors showed an opposite effect on the axonal K+ currents. Further experiments demonstrated that functional D1-like receptors were expressed at the main axon trunk and their activation could broaden the waveforms of axonal APs. Together, these results show that axonal K-V channels were subjected to dopamine modulation, and this modulation could regulate the waveforms of propagating APs at the axon, suggesting an important role of dopaminergic modulation of axonal K-V channels in regulating neuronal signalling. |
| 学科主题 | Neurosciences & Neurology ; Physiology |
| 资助信息 | 973 Program [2011CBA00400]; National Natural Science Foundation of China [31025012]; SA-SIBS Scholarship Program; Hundreds of Talents Program; Strategic Priority Research Program [XDA01020304]; Knowledge Innovation Project from Chinese Academy of Sciences [KSCX2-YW-R-102] |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2013-11-06 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/2569]  |
| 专题 | 上海神经科学研究所_神经所(总) |
| 推荐引用方式 GB/T 7714 | Yang, J,Ye, MY,Tian, CP,et al. Dopaminergic modulation of axonal potassium channels and action potential waveform in pyramidal neurons of prefrontal cortex[J]. JOURNAL OF PHYSIOLOGY-LONDON,2013,591(13):3233-3251. |
| APA | Yang, J,Ye, MY,Tian, CP,Yang, MP,Wang, YH,&Shu, YS.(2013).Dopaminergic modulation of axonal potassium channels and action potential waveform in pyramidal neurons of prefrontal cortex.JOURNAL OF PHYSIOLOGY-LONDON,591(13),3233-3251. |
| MLA | Yang, J,et al."Dopaminergic modulation of axonal potassium channels and action potential waveform in pyramidal neurons of prefrontal cortex".JOURNAL OF PHYSIOLOGY-LONDON 591.13(2013):3233-3251. |
入库方式： OAI收割
来源：上海神经科学研究所
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