beta-Catenin Is Critical for Cerebellar Foliation and Lamination
文献类型：期刊论文
| 作者 | Wen, J ; Yang, HB ; Zhou, B ; Lou, HF ; Duan, SM |
| 刊名 | PLOS ONE
 |
| 出版日期 | 2013 |
| 卷号 | 8期号:5页码:e64451-e64451 |
| 关键词 | GRANULE NEURON PRECURSORS MOUSE CEREBELLUM INT-1 PROTOONCOGENE NERVOUS-SYSTEM PURKINJE-CELLS DIFFERENTIATION EXPRESSION MORPHOGENESIS PROLIFERATION COMPLEXITY |
| ISSN号 | 1932-6203 |
| 通讯作者 | Duan, SM (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, Shanghai, Peoples R China.,duanshumin@zju.edu.cn |
| 英文摘要 | The cerebellum has a conserved foliation pattern and a well-organized layered structure. The process of foliation and lamination begins around birth. beta-catenin is a downstream molecule of Wnt signaling pathway, which plays a critical role in tissue organization. Lack of beta-catenin at early embryonic stages leads to either prenatal or neonatal death, therefore it has been difficult to resolve its role in cerebellar foliation and lamination. Here we used GFAP-Cre to ablate beta-catenin in neuronal cells of the cerebellum after embryonic day 12.5, and found an unexpected role of beta-catenin in determination of the foliation pattern. In the mutant mice, the positions of fissure formation were changed, and the meninges were improperly incorporated into fissures. At later stages, some lobules were formed by Purkinje cells remaining in deep regions of the cerebellum and the laminar structure was dramatically altered. Our results suggest that beta-catenin is critical for cerebellar foliation and lamination. We also found a non cell-autonomous role of beta-catenin in some developmental properties of major cerebellar cell types during specific stages. |
| 学科主题 | Science & Technology - Other Topics |
| 收录类别 | SCI |
| 资助信息 | Major State Basic Research Program of China [2011CB504400]; National Natural Science Foundation of China [31190060, 81221003, 30730037, 30870834]; PCSIRT |
| 语种 | 英语 |
| 公开日期 | 2013-11-06 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/2575]  |
| 专题 | 上海神经科学研究所_神经所(总) |
| 推荐引用方式 GB/T 7714 | Wen, J,Yang, HB,Zhou, B,et al. beta-Catenin Is Critical for Cerebellar Foliation and Lamination[J]. PLOS ONE,2013,8(5):e64451-e64451. |
| APA | Wen, J,Yang, HB,Zhou, B,Lou, HF,&Duan, SM.(2013).beta-Catenin Is Critical for Cerebellar Foliation and Lamination.PLOS ONE,8(5),e64451-e64451. |
| MLA | Wen, J,et al."beta-Catenin Is Critical for Cerebellar Foliation and Lamination".PLOS ONE 8.5(2013):e64451-e64451. |
入库方式： OAI收割
来源：上海神经科学研究所
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