Chinese Immune Multi-Omics Atlas
文献类型：期刊论文
| 作者 | Yin, Jianhua2,3,4; Zheng, Yuhui1,5; Huang, Zhuoli1,5; Zhou, Wenwen1,5; Yuan, Yue1,6; Cai, Pengfei1,6; Bai, Yong2,7,8; Yang, Shichen1,5; Gao, Yue9; Duan, Shanshan5,10 |
| 刊名 | SCIENCE
 |
| 出版日期 | 2026-01-08 |
| 卷号 | 391期号:6781页码:25 |
| ISSN号 | 0036-8075 |
| DOI | 10.1126/science.adt3130 |
| 英文摘要 | Human peripheral blood exhibits molecular and cellular heterogeneity across populations, yet the underlying mechanisms remain unclear. We present the Chinese Immune Multi-Omics Atlas (CIMA), characterizing molecular variations linked to sex, age, and genetic variants through multi-omics analysis of more than 10 million circulating immune cells from 428 Chinese adults. CIMA established an enhancer-driven gene regulatory network comprising 237 robust regulons; identified 9600 eGenes and 52,361 caPeaks at cell type resolution; and revealed pleiotropic associations among immune-related disease risk loci, cis-expression quantitative trait loci (QTLs), and chromatin accessibility QTLs. Furthermore, the cell language model CIMA-CLM predicted chromatin accessibility and evaluated the effects of noncoding variants from chromatin sequences and gene expression. CIMA provides a comprehensive reference for immune-related disease research. |
| 资助项目 | National Key Research and Development Program of China[2025YFC3409300] ; National Key Research and Development Program of China[2022YFC3400400] ; National Science and Technology Innovation 2030 Major Program[2021ZD0200100] ; National Natural Science Foundation of China[92474204] ; National Natural Science Foundation of China[32400550] ; China Postdoctoral Science Foundation[2023M732365] ; China Postdoctoral Science Foundation[2023M732369] ; Hangzhou Biomedical and Health Industry Development Support Science and Technology Special Project[2022WJC174] ; Guang Dong Basic and Applied Basic Research Foundation[2024B1515230003] ; Ministry of Education Singapore[FY2023] ; Ministry of Education Singapore[23-0434-A0001] ; Ministry of Education Singapore[22-5800-A0001] ; Ministry of Education Singapore[MOE-T2EP30123-0015] ; A*STAR under the Nucleic Acid Therapeutics Initiative[H24J5a0066] ; NUS Artificial Intelligence Institute[NAII-SG-2025-026] ; Singapore Therapeutics Development Review (STDR)[H25G0a0051] |
| WOS研究方向 | Science & Technology - Other Topics |
| 语种 | 英语 |
| WOS记录号 | WOS:001681996900004 |
| 出版者 | AMER ASSOC ADVANCEMENT SCIENCE |
| 源URL | [http://119.78.100.204/handle/2XEOYT63/42799]  |
| 专题 | 中国科学院计算技术研究所 |
| 通讯作者 | Cao, Yanan; Xu, Xun; Liu, Longqi; Jin, Xin; Liu, Chuanyu |
| 作者单位 | 1.BGI Res, Shenzhen, Peoples R China 2.BGI Res, State Key Lab Genome & Multiomics Technol, Shenzhen, Peoples R China 3.BGI Res, Shenzhen Proof Of Concept Ctr Digital Cytopathol, Shenzhen, Peoples R China 4.Shanxi Med Univ, BGI Collaborat Ctr Future Med, Taiyuan, Peoples R China 5.Univ Chinese Acad Sci, Coll Life Sci, Beijing, Peoples R China 6.BGI Res, State Key Lab Genome & Multiomics Technol, Hangzhou, Peoples R China 7.Guangdong Prov Key Lab Genome Read & Write, Shenzhen, Peoples R China 8.BGI Res, Shenzhen Key Lab Trans Biotechnol, Shenzhen, Peoples R China 9.South China Univ Technol, Sch Biol & Biol Engn, Guangzhou, Peoples R China 10.BGI Res, Hangzhou, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yin, Jianhua,Zheng, Yuhui,Huang, Zhuoli,et al. Chinese Immune Multi-Omics Atlas[J]. SCIENCE,2026,391(6781):25. |
| APA | Yin, Jianhua.,Zheng, Yuhui.,Huang, Zhuoli.,Zhou, Wenwen.,Yuan, Yue.,...&Liu, Chuanyu.(2026).Chinese Immune Multi-Omics Atlas.SCIENCE,391(6781),25. |
| MLA | Yin, Jianhua,et al."Chinese Immune Multi-Omics Atlas".SCIENCE 391.6781(2026):25. |
入库方式： OAI收割
来源：计算技术研究所
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