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MAP3K13-232aa encoded by circMAP3K13 enhances cisplatin-induced pyroptosis by directly binding to IKKα in gastric adenocarcinoma

文献类型：期刊论文

作者Du, Kaining1,2; Zhang, Xiaojing1,2,3; Qin, Ying4; Ma, Huizhen1; Bing, Chuhan1; Deng, Shiqi1,2; Chen, Yang1,2; Qin, Jiequan1; Chang, Shanshan1,2; Xiao, Siyu1
刊名CELL DEATH & DISEASE
出版日期2025-09-01
卷号16期号:1页码:17
ISSN号2041-4889
DOI10.1038/s41419-025-07991-5
英文摘要Gastric cancer (GC) is one of the most common and lethal malignancies in developing countries, with particularly high prevalence in China. Circular RNAs (circRNAs) have garnered increasing attention for their roles in disease pathogenesis. While circRNAs can be translated, there have been few investigations into the biological functions of "translatable circRNAs" in the initiation and progression of gastric adenocarcinoma. In this study, we identified a circRNA, circMAP3K13, which inhibits the proliferation and migration of GC cells. CircMAP3K13 was found to encode a previously unreported 26 kDa protein, designated MAP3K13-232aa. Mechanistically, MAP3K13-232aa binds directly to the kinase domain of IKK alpha and enhances its activity, thereby promoting NF-kappa B signaling. This activation leads to upregulation of NLRP3 and increased cisplatin-induced pyroptosis in GC cells. Moreover, MAP3K13-232aa enhances pyroptosis and reduces tumorigenicity and metastasis in vivo. Taken together, both circMAP3K13 and its encoded protein MAP3K13-232aa represent potential therapeutic targets in GC.
资助项目National Natural Science Foundation of China (National Science Foundation of China) ; Guangdong Provincial Key Laboratory of Regional Immunity and Diseases
WOS研究方向Cell Biology
语种英语
WOS记录号WOS:001561628600004
出版者SPRINGERNATURE
源URL[http://119.78.100.204/handle/2XEOYT63/41736]  
专题中国科学院计算技术研究所期刊论文_英文
通讯作者Peng, Yin
作者单位1.Shenzhen Univ Hlth Sci Ctr, Dept Pathol, Guangdong Prov Key Lab Genome Stabil & Dis Prevent, Shenzhen, Guangdong, Peoples R China
2.Shenzhen Univ, Shenzhen Univ Med Sch, Dept Pathol, Guangdong Prov Key Lab Reg Immun & Dis, Shenzhen, Guangdong, Peoples R China
3.Shenzhen Univ, Shenzhen Univ Med Sch, Dept Pathol, Guangdong Prov Key Lab Mol Oncol Pathol, Shenzhen, Guangdong, Peoples R China
4.Shenzhen Univ, Shenzhen Peoples Hosp 2, Affiliated Hosp 1, Dept Gastrointestinal Surg, Shenzhen, Guangdong, Peoples R China
5.Shenzhen Univ Gen Hosp, Dept Pathol, Shenzhen, Guangdong, Peoples R China
6.Shenzhen Inst Adv Technol, Ctr High Performance Comp, Shenzhen, Guangdong, Peoples R China
7.Howard Univ, Coll Med, Dept Med & Canc Ctr, Washington, DC USA
8.Meharry Med Ctr, Dept Med, Nashville, TN USA
推荐引用方式
GB/T 7714		 Du, Kaining,Zhang, Xiaojing,Qin, Ying,et al. MAP3K13-232aa encoded by circMAP3K13 enhances cisplatin-induced pyroptosis by directly binding to IKKα in gastric adenocarcinoma[J]. CELL DEATH & DISEASE,2025,16(1):17.
APA Du, Kaining.,Zhang, Xiaojing.,Qin, Ying.,Ma, Huizhen.,Bing, Chuhan.,...&Peng, Yin.(2025).MAP3K13-232aa encoded by circMAP3K13 enhances cisplatin-induced pyroptosis by directly binding to IKKα in gastric adenocarcinoma.CELL DEATH & DISEASE,16(1),17.
MLA Du, Kaining,et al."MAP3K13-232aa encoded by circMAP3K13 enhances cisplatin-induced pyroptosis by directly binding to IKKα in gastric adenocarcinoma".CELL DEATH & DISEASE 16.1(2025):17.

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来源：计算技术研究所

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