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Ionophore-based polymeric membrane potentiometric ion sensors for long-term applications in real-world scenarios: challenges, strategies, and perspectives

文献类型：期刊论文

作者Liu, Zhe1,2,4; Cui, Guohua2,4; Zhao, Haijie2,4; Gao, Zhenhui2,4; Liang, Rongning4; Qin, Wei3,4,5
刊名COORDINATION CHEMISTRY REVIEWS
出版日期2026-08-15
卷号561页码:39
关键词Ionophore Potentiometry Polymeric membrane ion-selective electrode In-situ measurement In-vivo analysis Long-term stability
ISSN号0010-8545
DOI10.1016/j.ccr.2026.217857
通讯作者Liang, Rongning(rnliang@yic.ac.cn) ; Qin, Wei(wqin@yic.ac.cn)
英文摘要Ion detection is of great importance for various fields such as disease diagnosis, environmental monitoring, ecological process evolution and food safety control because most processes and mechanisms found in nature rely on ions. As a reliable tool for rapid ion sensing, potentiometric polymeric membrane ion-selective electrodes (ISEs) have been routinely used, for which an ionophore capable of reversibly binding the target ion is employed as the key component in the sensing membrane. During the past decades, tremendous fundamental advances have been made, which have fueled renewed interests in pursuing active research in this field. Despite the successful achievements of these ionophore-based sensors, the challenges such as the short lifespan, persistent signal drift, and poor bio/environmental compatibility have posed serious limits to their real-world long-term applications. This review summarizes recent progress in the development of robust polymeric membrane potentiometric ISEs, with particular emphasis on the challenges associated with in vivo, in situ, and long-term measurements, as well as the corresponding resolution strategies. Key approaches discussed include prevention of membrane-component leaching, development of biocompatible and environmentally compatible sensing membranes, and design of long-term stable solid-contact electrodes, which collectively enable the transition from short-term sensing toward reliable long-term potentiometric monitoring. The applications of these sensors in wearable and implantable devices and in environmental monitoring platforms are also highlighted. Future perspectives for potentiometric sensors aimed at long-term reliable environmental and biomedical monitoring are outlined.
WOS关键词FIELD-EFFECT TRANSISTORS ; NITRATE-SELECTIVE ELECTRODES ; PLASTICIZER-FREE POLYMER ; POLY(VINYL CHLORIDE) MEMBRANE ; ATTENUATED TOTAL-REFLECTION ; SILICONE-RUBBER MEMBRANES ; SELF-ASSEMBLED MONOLAYERS ; EFFECTIVE SOLID CONTACT ; LOWER DETECTION LIMIT ; IN-SITU MEASUREMENTS
资助项目National Key Research and Development Program of China[2024YFE0211700] ; National Natural Science Foundation of China[U2006208] ; National Natural Science Foundation of China[22176209] ; Key R&D Program of Shandong Province[2022CXPT019] ; Key Deployment Project of Centre for Ocean Mega-Research of Science, Chinese Academy of Sciences[COMS2020J06] ; Shandong Provincial Natural Science Foundation[ZR2024MB144] ; Taishan Scholar Program of Shandong Province[tspd20181215] ; Taishan Scholar Program of Shandong Province[tsqn202103132] ; Special Supporting Project of Yantai
WOS研究方向Chemistry
语种英语
WOS记录号WOS:001741276000001
出版者ELSEVIER SCIENCE SA
源URL[http://ir.qdio.ac.cn/handle/337002/204904]  
专题中国科学院海洋研究所
通讯作者Liang, Rongning; Qin, Wei
作者单位1.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Shandong, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Qingdao Marine Sci & Technol Ctr, Lab Marine Biol & Biotechnol, Qingdao 266237, Shandong, Peoples R China
4.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Shandong Key Lab Coastal Zone Environm Proc & Ecol, Yantai 264003, Shandong, Peoples R China
5.Chinese Acad Sci, Ctr Ocean Mega Sci, Qingdao 266071, Shandong, Peoples R China
推荐引用方式
GB/T 7714		 Liu, Zhe,Cui, Guohua,Zhao, Haijie,et al. Ionophore-based polymeric membrane potentiometric ion sensors for long-term applications in real-world scenarios: challenges, strategies, and perspectives[J]. COORDINATION CHEMISTRY REVIEWS,2026,561:39.
APA Liu, Zhe,Cui, Guohua,Zhao, Haijie,Gao, Zhenhui,Liang, Rongning,&Qin, Wei.(2026).Ionophore-based polymeric membrane potentiometric ion sensors for long-term applications in real-world scenarios: challenges, strategies, and perspectives.COORDINATION CHEMISTRY REVIEWS,561,39.
MLA Liu, Zhe,et al."Ionophore-based polymeric membrane potentiometric ion sensors for long-term applications in real-world scenarios: challenges, strategies, and perspectives".COORDINATION CHEMISTRY REVIEWS 561(2026):39.

入库方式： OAI收割

来源：海洋研究所

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