Genome analysis-led discovery of antimicrobial and herbicidal cytochalasans from the cold-seep-sourced endozoic Curvularia verruculosa CS-129
文献类型：期刊论文
| 作者 | Hu, Xue-Yi2; Li, Xiao-Ming2; Li, Xin1,2; Wang, Bin-Gui1,2,3; Meng, Ling-Hong1,2,3 |
| 刊名 | BIOORGANIC CHEMISTRY
 |
| 出版日期 | 2026 |
| 卷号 | 168页码:10 |
| 关键词 | Genome analysis Curvularia verruculosa Deep sea Cold seep fungus Cytochalasans Antimicrobial activity Herbicidal activity |
| ISSN号 | 0045-2068 |
| DOI | 10.1016/j.bioorg.2025.109304 |
| 通讯作者 | Wang, Bin-Gui(wangbg@ms.qdio.ac.cn) ; Meng, Ling-Hong(menglh@ms.qdio.ac.cn) |
| 英文摘要 | Cytochalasans are abundant in structural diversity and potent in biological activities. Here, after the genome analysis of Curvularia verruculosa and by adding Na2S and Na2S2O3 to rice medium based on one strain-many compounds (OSMAC) strategy, we obtained and describe the characterization of six previously undescribed cytochalasans (1-6) from marine endozoic fungus Curvularia verruculosa CS-129 which was isolated from the inner fresh tissue of the deep-sea squat lobster Shinkaia crosnieri collected from the cold-seep area of the South China Sea. Among them, vercytoaspochalasin A (1) represents the first reported aspochalasin (cytochalasans biosynthesized by leucine) combining a 14-membered macrolide, while compound 3 is the first reported cytochalasan with an iodine substituent group and 20-methoxycytochalasin B gamma-lactone (6) is a rare macrocyclic ringopening natural cytochalasin coupled with a furan ring. Compounds 2, 5, 7, and 8 demonstrated differential antimicrobial efficacy against both aquatic-pathogenic bacteria and plant-pathogenic fungi with varying potency. In addition, compounds 5 and 7 could significantly inhibit the radicle growth of Amaranthus retroflexus seedlings with a dose-dependent relationship. |
| WOS关键词 | ENDOPHYTIC FUNGUS ; DERIVATIVES |
| 资助项目 | National Key Research and Development Program of China[2022YFC2804700] ; Shandong Postdoctoral Science Foundation[SDCX-ZG-202302023] ; Shandong Provincial Natural Science Foundation[ZR2024QD236] ; National Major Science |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:001632864900001 |
| 出版者 | ACADEMIC PRESS INC ELSEVIER SCIENCE |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/204381]  |
| 专题 | 海洋研究所_实验海洋生物学重点实验室 |
| 通讯作者 | Wang, Bin-Gui; Meng, Ling-Hong |
| 作者单位 | 1.Qingdao Marine Sci & Technol Ctr, Lab Marine Biol & Biotechnol, Wenhai Rd 1, Qingdao 266237, Peoples R China 2.Chinese Acad Sci, Inst Oceanol, Lab Expt Marine Biol, Nanhai Rd 7, Qingdao 266071, Peoples R China 3.Univ Chinese Acad Sci, Yuquan Rd 19A, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Hu, Xue-Yi,Li, Xiao-Ming,Li, Xin,et al. Genome analysis-led discovery of antimicrobial and herbicidal cytochalasans from the cold-seep-sourced endozoic Curvularia verruculosa CS-129[J]. BIOORGANIC CHEMISTRY,2026,168:10. |
| APA | Hu, Xue-Yi,Li, Xiao-Ming,Li, Xin,Wang, Bin-Gui,&Meng, Ling-Hong.(2026).Genome analysis-led discovery of antimicrobial and herbicidal cytochalasans from the cold-seep-sourced endozoic Curvularia verruculosa CS-129.BIOORGANIC CHEMISTRY,168,10. |
| MLA | Hu, Xue-Yi,et al."Genome analysis-led discovery of antimicrobial and herbicidal cytochalasans from the cold-seep-sourced endozoic Curvularia verruculosa CS-129".BIOORGANIC CHEMISTRY 168(2026):10. |
入库方式： OAI收割
来源：海洋研究所
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