Antifungal phenolic glucosides and related congeners from the cold-seep-derived Talaromyces trachyspermus CS-106
文献类型：期刊论文
| 作者 | Feng, Xing-Yan2,3,4; Yang, Sui-Qun2,4; Li, Xiao-Ming2,4; Li, Xin2,3,4; Wang, Bin-Gui1,2,3,4; Meng, Ling-Hong2,3,4 |
| 刊名 | PHYTOCHEMISTRY
 |
| 出版日期 | 2026-03-01 |
| 卷号 | 243页码:12 |
| 关键词 | Talaromyces trachyspermus Trichocomaceae Marine-sourced fungus Deep-sea Phenolic glucosides Antimicrobial activity Fungicides |
| ISSN号 | 0031-9422 |
| DOI | 10.1016/j.phytochem.2025.114737 |
| 通讯作者 | Wang, Bin-Gui(wangbg@ms.qdio.ac.cn) ; Meng, Ling-Hong(menglh@ms.qdio.ac.cn) |
| 英文摘要 | Chemical investigation of the cold-seep-sourced fungus Talaromyces trachyspermus CS-106 resulted in the isolation of six previously undescribed phenolic glucopyranosides, talarosides A-F (1-6), two previously undescribed phenolic cysteine derivatives, talacysteines A and B (7 and 8), and five known congeners 9-13. The results from in vitro bioassay indicated that compounds 3, 6, and 9 displayed potent activities against several tested phytopathogenic fungal strains. Specially, the chloroquinone derivative, 2-chloro-5-methoxy-3-methylcyclohexa-2,5-diene-1,4-dione (compound 9), exhibited a broad spectrum of fungicidal activity against Alternaria brassicae, Colletotrichum gloeosporioides, Fusarium graminearum, and F. oxysporum, with MIC values ranging from 0.5 to 4 mu g/mL. In vivo testing on tomato fruits showed that 9 displayed considerable curative efficacy against F. oxysporum. Both scanning electron microscopy and cryo-SEM analysis indicated that 9 possessed a strong ability to destroy the surface morphology of mycelia and seriously interfere with the growth of the fungal pathogen. Compound 9 also exhibited pronounced succinate dehydrogenase (SDH) inhibitory activity from the in vitro SDH inhibitory assay. Molecular docking simulations were performed to explore the intermolecular interaction of 9 with SDH enzyme from F. oxysporum. These findings presented a promising lead compound such as compound 9 for the discovery of SDH inhibitor as antifungal agents. |
| WOS关键词 | FUNGUS ; DERIVATIVES ; RESISTANCE |
| 资助项目 | National Natural Science Foundation of China[42176115] ; National Natural Science Foundation of China[W2411036] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Plant Sciences |
| 语种 | 英语 |
| WOS记录号 | WOS:001635972100001 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/204411]  |
| 专题 | 海洋研究所_实验海洋生物学重点实验室 |
| 通讯作者 | Wang, Bin-Gui; Meng, Ling-Hong |
| 作者单位 | 1.Qingdao Marine Sci & Technol Ctr, Lab Marine Biol & Biotechnol, Wenhai Rd 1, Qingdao 266237, Peoples R China 2.Chinese Acad Sci, Inst Oceanol, CAS, Nanhai Rd 7, Qingdao 266071, Peoples R China 3.Univ Chinese Acad Sci, Yuquan Rd 19A, Beijing 100049, Peoples R China 4.Chinese Acad Sci, Inst Oceanol, Shandong Prov Key Lab Expt Marine Biol, Nanhai Rd 7, Qingdao 266071, Peoples R China |
| 推荐引用方式 GB/T 7714 | Feng, Xing-Yan,Yang, Sui-Qun,Li, Xiao-Ming,et al. Antifungal phenolic glucosides and related congeners from the cold-seep-derived Talaromyces trachyspermus CS-106[J]. PHYTOCHEMISTRY,2026,243:12. |
| APA | Feng, Xing-Yan,Yang, Sui-Qun,Li, Xiao-Ming,Li, Xin,Wang, Bin-Gui,&Meng, Ling-Hong.(2026).Antifungal phenolic glucosides and related congeners from the cold-seep-derived Talaromyces trachyspermus CS-106.PHYTOCHEMISTRY,243,12. |
| MLA | Feng, Xing-Yan,et al."Antifungal phenolic glucosides and related congeners from the cold-seep-derived Talaromyces trachyspermus CS-106".PHYTOCHEMISTRY 243(2026):12. |
入库方式： OAI收割
来源：海洋研究所
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