Molecular basis of glucose homeostasis in the Pacific oyster (Crassostrea gigas): insights from transcriptome and hexokinase phylogeny analysis
文献类型：期刊论文
| 作者 | Liu, Zhitong3,4; Miao, Xiaojing3; Xu, Fei1,2,3 |
| 刊名 | JOURNAL OF OCEANOLOGY AND LIMNOLOGY
 |
| 出版日期 | 2025-12-16 |
| 页码 | 11 |
| 关键词 | glucose homeostasis
hexokinase
|
| ISSN号 | 2096-5508 |
| DOI | 10.1007/s00343-025-5118-9 |
| 通讯作者 | Xu, Fei(xufei@qdio.ac.cn) |
| 英文摘要 | Glucose homeostasis is a fundamental physiological process in both vertebrates and invertebrates, yet its regulatory mechanisms in molluscs remain largely unexplored. This study investigates temporal hemolymph glucose dynamics and associated molecular responses in the Pacific oyster Crassostrea gigas. Annual monitoring revealed significant seasonal variation in hemolymph glucose concentrations, with post-spawning oysters exhibiting the lowest levels. A glucose injection experiment demonstrated rapid uptake kinetics, followed by a return to baseline, suggesting the presence of efficient metabolic regulation. Transcriptomic analysis on hepatopancreas tissue identified cgHK2-2 as the dominant hexokinase isoform induced by hyperglycemia, while other HK genes (cgHK2 and cgHK2-like) showed tissue-specific but non-inducible expression profiles in the investigated tissue. Furthermore, upregulation of cgPPP1R3B and cgPCSK1 indicate possibly conserved glycogen metabolism and insulinlike signaling pathways. Phylogenetic analysis revealed divergent evolutionary trajectories of hexokinase in protostomes versus chordates, with oysters lacking a clear glucokinase orthologue. These findings highlight key molecular players in oyster glucose metabolism and suggest both conserved and lineage-specific regulatory strategies. |
| WOS关键词 | INSULIN ; GLUCOKINASE ; ALIGNMENT ; STRESS ; INDEX |
| WOS研究方向 | Marine & Freshwater Biology ; Oceanography |
| 语种 | 英语 |
| WOS记录号 | WOS:001638810500001 |
| 出版者 | SCIENCE PRESS |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/204430]  |
| 专题 | 海洋研究所_实验海洋生物学重点实验室 |
| 通讯作者 | Xu, Fei |
| 作者单位 | 1.Qingdao Marine Sci & Technol Ctr, Lab Marine Biol & Biotechnol, Qingdao 266000, Peoples R China 2.Shandong Technol Innovat Ctr Oyster Seed Ind, Qingdao 266000, Peoples R China 3.Chinese Acad Sci, Inst Oceanol, State Key Lab Breeding Biotechnol & Sustainable Aq, Qingdao 266000, Peoples R China 4.Qingdao Agr Univ, Sch Marine Sci & Engn, Qingdao 266109, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Zhitong,Miao, Xiaojing,Xu, Fei. Molecular basis of glucose homeostasis in the Pacific oyster (Crassostrea gigas): insights from transcriptome and hexokinase phylogeny analysis[J]. JOURNAL OF OCEANOLOGY AND LIMNOLOGY,2025:11. |
| APA | Liu, Zhitong,Miao, Xiaojing,&Xu, Fei.(2025).Molecular basis of glucose homeostasis in the Pacific oyster (Crassostrea gigas): insights from transcriptome and hexokinase phylogeny analysis.JOURNAL OF OCEANOLOGY AND LIMNOLOGY,11. |
| MLA | Liu, Zhitong,et al."Molecular basis of glucose homeostasis in the Pacific oyster (Crassostrea gigas): insights from transcriptome and hexokinase phylogeny analysis".JOURNAL OF OCEANOLOGY AND LIMNOLOGY (2025):11. |
入库方式： OAI收割
来源：海洋研究所
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