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Identification of a novel antimicrobial peptide Gp-AMP1 with broad-spectrum and exceptional stability from deep-sea mussel Gigantidas platifrons

文献类型：期刊论文

作者Han, Guanghui1,2; Chen, Hao1,2,8; Zhuo, Lianhong1,2,5,8; Yu, Haoyu1,2,8; Wu, Ning1,2,8; Wang, Minxiao1,2,6,8; Song, Jiangning3,4; Li, Chaolun1,2,6,7,8
刊名FOOD CHEMISTRY
出版日期2026-02-01
卷号501页码:12
关键词Bioactive peptide Deep-sea mussel Antibacterial activity Antibacterial mechanism Natural preservative
ISSN号0308-8146
DOI10.1016/j.foodchem.2025.147576
通讯作者Chen, Hao(chenhao@qdio.ac.cn) ; Li, Chaolun(lcl@qdio.ac.cn)
英文摘要As crucial components of the innate immunity of animals, antimicrobial peptides (AMPs) offer a promising alternative to chemical antibiotics in both clinical and food-industry applications. Notably, deep-sea invertebrates-particularly those that form close symbiosis with specific bacteria-have emerged as a novel source for discovering unique AMPs. Here, a novel AMP, Gp-AMP1, was isolated from the deep-sea mussel Gigantidas platifrons, and characterized for its broad-spectrum bactericidal properties against multiple pathogenic or spoilage bacteria. Further investigations revealed that Gp-AMP1 effectively compromises bacterial cell membranes and elevates intracellular reactive oxygen species levels, leading to bacterial cell death. Additionally, GpAMP1 demonstrates robust thermal and pH stability, low cytotoxicity, and minimal hemolytic activity, and could significantly inhibit the growth of spoilage bacteria of pork. These findings highlight the potential of Gp-AMP1 as a promising antibiotic candidate for meat preservation and medical applications, while also underscoring the value of deep-sea invertebrates as a rich source of novel AMPs.
WOS关键词QUALITY ; MICROBIOTA ; FILLETS
资助项目National Natural Science Foundation of China[42327805H] ; National Natural Science Foundation of China[42221005] ; National Natural Science Foundation of China[42030407] ; National Natural Science Foundation of China[42106134] ; Key Research Program of Frontier Sciences[ZDBS-LY-DQC032]
WOS研究方向Chemistry ; Food Science & Technology ; Nutrition & Dietetics
语种英语
WOS记录号WOS:001645196600001
出版者ELSEVIER SCI LTD
源URL[http://ir.qdio.ac.cn/handle/337002/204502]  
专题海洋研究所_实验海洋生物学重点实验室
通讯作者Chen, Hao; Li, Chaolun
作者单位1.Chinese Acad Sci, Inst Oceanol, Lab Marine Ecol & Environm Sci, Qingdao 266071, Peoples R China
2.Chinese Acad Sci, Inst Oceanol, Ctr Deep Sea Res, Qingdao 266071, Peoples R China
3.Monash Univ, Dept Biochem & Mol Biol, Wellington Rd, Melbourne, Vic 3800, Australia
4.Monash Univ, Biomed Discovery Inst, Wellington Rd, Melbourne, Vic 3800, Australia
5.Fujian Agr & Forestry Univ, Sch Future Technol, Fuzhou 350002, Peoples R China
6.Jiangsu Ocean Univ, Coinnovat Ctr Jiangsu Marine Bioind Technol, Lianyungang 222005, Peoples R China
7.Chinese Acad Sci, South China Sea Inst Oceanol, Guangzhou 510301, Peoples R China
8.Chinese Acad Sci, Inst Oceanol, Lab Expt Marine Biol, Qingdao 266071, Peoples R China
推荐引用方式
GB/T 7714		 Han, Guanghui,Chen, Hao,Zhuo, Lianhong,et al. Identification of a novel antimicrobial peptide Gp-AMP1 with broad-spectrum and exceptional stability from deep-sea mussel Gigantidas platifrons[J]. FOOD CHEMISTRY,2026,501:12.
APA Han, Guanghui.,Chen, Hao.,Zhuo, Lianhong.,Yu, Haoyu.,Wu, Ning.,...&Li, Chaolun.(2026).Identification of a novel antimicrobial peptide Gp-AMP1 with broad-spectrum and exceptional stability from deep-sea mussel Gigantidas platifrons.FOOD CHEMISTRY,501,12.
MLA Han, Guanghui,et al."Identification of a novel antimicrobial peptide Gp-AMP1 with broad-spectrum and exceptional stability from deep-sea mussel Gigantidas platifrons".FOOD CHEMISTRY 501(2026):12.

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来源：海洋研究所

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