Unraveling the microRNA regulatory network underlying the planktonic-to-benthic transition in the Pacific oyster
文献类型：期刊论文
| 作者 | Xie, Yusu3,4; Yang, Mingyu2,3,4; Sun, Haiming4; Xu, Fei1,3,4 |
| 刊名 | AQUACULTURE REPORTS
 |
| 出版日期 | 2026-03-15 |
| 卷号 | 46页码:11 |
| 关键词 | MiRNA Crassostrea gigas Planktonic-benthic transition Settlement Metamorphosis |
| ISSN号 | 2352-5134 |
| DOI | 10.1016/j.aqrep.2025.103304 |
| 通讯作者 | Xu, Fei(xufei@qdio.ac.cn) |
| 英文摘要 | The Pacific oyster, Crassostrea gigas, undergoes a critical developmental transition from planktonic larvae to sessile benthic juveniles, a process essential for both aquaculture productivity and the stability of marine ecosystems. While environmental and neuroendocrine cues regulating this transition have been extensively studied, the contribution of microRNAs (miRNAs) remains largely unexplored. In this study, we employed a high-resolution temporal sampling strategy to investigate oyster metamorphosis, identified 33 miRNAs associated with larval settlement and metamorphosis. Additionally, we uncovered 35 highly correlated miRNA-target gene pairs, revealing a complex post-transcriptional regulatory network. We further validated the expression pattern of the potential regulatory hub miRNA novel_mir_80 and confirmed its presence through whole-mount in situ hybridization using LNA-modified probes. Functional annotation of target genes highlighted key roles in adhesion, signal transduction, protein homeostasis, cytoskeleton remodeling, genome stability, and transcriptional and epigenetic regulation. These results underscore the pivotal role of miRNAs in orchestrating developmental reprogramming during the planktonic-benthic transition. Our findings not only expand current understanding of miRNA-mediated gene regulation in C. gigas, but also provide novel molecular targets with potential applications in oyster breeding and aquaculture management. |
| WOS关键词 | MUSCLE DEVELOPMENT ; CELL ; GENE ; METAMORPHOSIS ; EXPRESSION ; SETTLEMENT ; PROTEINS ; POLARITY ; ENCODES ; LARVAE |
| 资助项目 | National Key R&D Program of China[2022YFD2401203] ; Science & Technology Innovation Project of Laoshan Laboratory[LSKJ202203001] ; Key Research and Development Program of Guangxi[GKN AB2506910034] ; Taishan Scholars Program[tsqn202211250] |
| WOS研究方向 | Fisheries |
| 语种 | 英语 |
| WOS记录号 | WOS:001644454300001 |
| 出版者 | ELSEVIER |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/204505]  |
| 专题 | 海洋研究所_实验海洋生物学重点实验室 |
| 通讯作者 | Xu, Fei |
| 作者单位 | 1.Oyster Seed Ind, Shandong Technol Innovat Ctr, Qingdao 266105, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Qingdao Marine Sci & Technol Ctr, Lab Marine Biol & Biotechnol, Qingdao 266237, Peoples R China 4.Chinese Acad Sci, Inst Oceanol, State Key Lab Breeding Biotechnol & Sustainable Aq, Qingdao 266000, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xie, Yusu,Yang, Mingyu,Sun, Haiming,et al. Unraveling the microRNA regulatory network underlying the planktonic-to-benthic transition in the Pacific oyster[J]. AQUACULTURE REPORTS,2026,46:11. |
| APA | Xie, Yusu,Yang, Mingyu,Sun, Haiming,&Xu, Fei.(2026).Unraveling the microRNA regulatory network underlying the planktonic-to-benthic transition in the Pacific oyster.AQUACULTURE REPORTS,46,11. |
| MLA | Xie, Yusu,et al."Unraveling the microRNA regulatory network underlying the planktonic-to-benthic transition in the Pacific oyster".AQUACULTURE REPORTS 46(2026):11. |
入库方式： OAI收割
来源：海洋研究所
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