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CSN2 of COP9 signalosome underpins high temperature adaptation of the diatom Phaeodactylum tricornutum through regulating protein ubiquitination

文献类型：期刊论文

作者Li, Xin1,2,3,4; Zhou, Lu5; Yang, Wenting2,3; Wang, Hong2,3,4; Liu, Xuehua1,2,3; Wu, Songcui1,2,3; Gu, Wenhui1,2,3; Wang, Lijun1,2,3; Xie, Xiujun1,2,3; Lin, Senjie6
刊名ALGAL RESEARCH-BIOMASS BIOFUELS AND BIOPRODUCTS
出版日期2026
卷号93页码:10
关键词COP9 signalosome Diatoms High temperature Phaeodactylum tricornutum Ubiquitination Ubiquitylomics
ISSN号2211-9264
DOI10.1016/j.algal.2025.104457
通讯作者Gao, Shan(shangao@qdio.ac.cn) ; Wang, Guangce(gcwang@qdio.ac.cn)
英文摘要Global warming threatens the productivity and diversity of marine diatoms which are responsible for 20 % of global primary productivity. However, the molecular mechanisms behind their adaptation to high temperature are poorly understood. Here, we found that the genes encoding COP9 signalosome (CSN) subunits are widely distributed in marine phytoplankton particularly diatoms, and CSN2 is the most conserved subunit which plays an important role in the adaptation of marine diatoms to high temperature. Moreover, we found CSN2 mutants of the model diatom Phaeodactylum tricornutum exhibited the decline of growth at high temperatures (25 degrees C) and decrease of the tolerance to ultraviolet radiation. The deletion mutation of CSN2 also caused alteration of P. tricornutum cell shape. Furthermore, integrated ubiquitylomic and proteomic analyses of CSN2 mutant of P. tricornutum revealed that as a scaffold, CSN2 regulated the ubiquitination levels of proteins mainly including heat shock proteins, ribosomal proteins, and histones. All these results suggested that CSN2 played a critical role in P. tricornutum high temperature adaptation by regulating protein ubiquitination.
WOS关键词MARINE HEATWAVES ; LIGASES ; NEDDYLATION ; DIVERSITY ; PATHWAYS ; INCREASE ; OCEAN
资助项目Foundation of Guangdong Province[2023A1515012590] ; Shenzhen Science and Technology Innovation Commission[RCBS20231211090733055] ; Research Fund for the Taishan Scholar Project of Shandong Province[tspd20210316]
WOS研究方向Biotechnology & Applied Microbiology
语种英语
WOS记录号WOS:001646118700001
出版者ELSEVIER
源URL[http://ir.qdio.ac.cn/handle/337002/204532]  
专题海洋研究所_实验海洋生物学重点实验室
通讯作者Gao, Shan; Wang, Guangce
作者单位1.Chinese Acad Sci, Inst Oceanol, Shandong Prov Key Lab Expt Marine Biol, Qingdao, Peoples R China
2.Chinese Acad Sci, Key Lab Breeding Biotechnol & Sustainable Aquacult, Qingdao, Peoples R China
3.Qingdao Marine Sci & Technol Ctr, Lab Marine Biol & Biotechnol, Qingdao, Peoples R China
4.Univ Chinese Acad Sci, Beijing, Peoples R China
5.Southern Univ Sci & Technol, Sch Life Sci, Shenzhen, Peoples R China
6.Univ Connecticut, Dept Marine Sci, Groton, CT USA
7.Chinese Acad Sci, Shenzhen Inst Adv technol, Coll Synthet Biol, Shenzhen, Peoples R China
推荐引用方式
GB/T 7714		 Li, Xin,Zhou, Lu,Yang, Wenting,et al. CSN2 of COP9 signalosome underpins high temperature adaptation of the diatom Phaeodactylum tricornutum through regulating protein ubiquitination[J]. ALGAL RESEARCH-BIOMASS BIOFUELS AND BIOPRODUCTS,2026,93:10.
APA Li, Xin.,Zhou, Lu.,Yang, Wenting.,Wang, Hong.,Liu, Xuehua.,...&Wang, Guangce.(2026).CSN2 of COP9 signalosome underpins high temperature adaptation of the diatom Phaeodactylum tricornutum through regulating protein ubiquitination.ALGAL RESEARCH-BIOMASS BIOFUELS AND BIOPRODUCTS,93,10.
MLA Li, Xin,et al."CSN2 of COP9 signalosome underpins high temperature adaptation of the diatom Phaeodactylum tricornutum through regulating protein ubiquitination".ALGAL RESEARCH-BIOMASS BIOFUELS AND BIOPRODUCTS 93(2026):10.

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来源：海洋研究所

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