From land to sea: Natural products as promising agents against hyperuricemia
文献类型：期刊论文
| 作者 | Fu, Mengying1,2,5; Hunter, Roger3; Farooqi, Ammad Ahmad4; Zhang, Quanbin1,5; Wang, Jing1,5; Geng, Lihua1,5; Yue, Yang1,5; Yang, Yan1,2; Wu, Ning1,2,5 |
| 刊名 | FOOD BIOSCIENCE
 |
| 出版日期 | 2026 |
| 卷号 | 75页码:18 |
| 关键词 | Terrestrial natural products Marine natural products Hyperuricemia Uric acid Urate transporters |
| ISSN号 | 2212-4292 |
| DOI | 10.1016/j.fbio.2025.108183 |
| 通讯作者 | Hunter, Roger(roger.hunter@uct.ac.za) ; Wu, Ning(wuning@qdio.ac.cn) |
| 英文摘要 | Hyperuricemia is a pervasive metabolic disorder defined by dysregulated urate homeostasis, arising from uric acid overproduction, impaired excretion, or both, which elevates serum urate concentrations beyond the physiological saturation threshold. Emerging evidence confirms it as a pivotal risk factor for a spectrum of complications, encompassing gout, renal calculi, and cardiovascular diseases. As its global prevalence escalates, hyperuricemia imposes a considerable burden on public health systems worldwide. Current pharmacological interventions are frequently constrained by adverse effects and inadequate patient tolerance, thus highlighting an urgent need to develop safer and more efficacious regulatory strategies. Natural products have emerged as a promising source for the dietary modulation and adjunctive treatment of hyperuricemia, with their uratelowering efficacy being increasingly validated. This review provides a comprehensive and critical analysis of recent advances in this field. It systematically summarizes well-characterized anti-hyperuricemic agents derived from terrestrial sources, while placing a particular emphasis on the frontier of marine-derived natural products-an underexplored reservoir with remarkable potential. We elaborate the multi-targeted mechanisms through which these natural products exert their effects, primarily through the inhibition of key enzymes in uric acid biosynthesis and the promotion of renal urate excretion. And also, the body of evidence confirms that these terrestrial and marine natural products offer potent hypouricemic activity coupled with generally favorable safety profiles. Accordingly, these natural products serve as a versatile reservoir of candidate molecules for the development of dietary adjuncts and innovative therapeutic agents tailored to hyperuricemia management. |
| WOS关键词 | SERUM URIC-ACID ; XANTHINE-OXIDASE ; GOUT ; BENZBROMARONE ; INHIBITION |
| 资助项目 | Self-Deployed Project of the Institute of Oceanology, Chinese Academy of Sciences[E52476101Q] ; Nat-ural Science Foundation of Nantong[Jc2023088] |
| WOS研究方向 | Food Science & Technology |
| 语种 | 英语 |
| WOS记录号 | WOS:001656505200001 |
| 出版者 | ELSEVIER |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/204544]  |
| 专题 | 海洋研究所_实验海洋生物学重点实验室 |
| 通讯作者 | Hunter, Roger; Wu, Ning |
| 作者单位 | 1.Chinese Acad Sci, Inst Oceanol, CAS & Shandong Prov Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 2.Qingdao Marine Sci & Technol Ctr, Lab Marine Drugs & Bioprod, Qingdao 266237, Peoples R China 3.Univ Cape Town, Chem Dept, ZA-7701 Cape Town, South Africa 4.Inst Biomed & Genet Engn IBGE, Dept Mol Oncol, Islamabad 54000, Pakistan 5.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Fu, Mengying,Hunter, Roger,Farooqi, Ammad Ahmad,et al. From land to sea: Natural products as promising agents against hyperuricemia[J]. FOOD BIOSCIENCE,2026,75:18. |
| APA | Fu, Mengying.,Hunter, Roger.,Farooqi, Ammad Ahmad.,Zhang, Quanbin.,Wang, Jing.,...&Wu, Ning.(2026).From land to sea: Natural products as promising agents against hyperuricemia.FOOD BIOSCIENCE,75,18. |
| MLA | Fu, Mengying,et al."From land to sea: Natural products as promising agents against hyperuricemia".FOOD BIOSCIENCE 75(2026):18. |
入库方式： OAI收割
来源：海洋研究所
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