Marine Bromophenol Derivatives as a Novel Class of Potent Small-Molecule STING Agonists
文献类型：期刊论文
| 作者 | Tang, Manqing3; Guo, Qiuhui3; Wang, Ping3; Li, Yunfei3; Jiang, Bo1,2 |
| 刊名 | CURRENT ISSUES IN MOLECULAR BIOLOGY
 |
| 出版日期 | 2026-01-05 |
| 卷号 | 48期号:1页码:15 |
| 关键词 | STING agonists bromophenol derivatives cancer immunotherapy |
| ISSN号 | 1467-3037 |
| DOI | 10.3390/cimb48010061 |
| 通讯作者 | Li, Yunfei(liyunfei@tjutcm.edu.cn) ; Jiang, Bo(jiangbo@qdio.ac.cn) |
| 英文摘要 | Activation of the stimulator of interferon genes (STING) pathway has emerged as a promising strategy for cancer immunotherapy. However, the initial cyclic dinucleotide (CDN) analogs developed as STING agonists have shown limited efficacy in clinical trials, prompting interest in non-CDN small-molecule alternatives. In this study, we identified a novel series of bromophenol derivatives as effective STING agonists. Among these derivatives, OSBP63 robustly activated the STING signaling pathway, resulting in enhanced phosphorylation of interferon regulatory factor 3 (p-IRF3) and increased secretion of interferon-beta (IFN-beta). Co-administration of Marine Bromophenol Derivative (OSBP63) with paclitaxel (PTX), a conventional anticancer drug, significantly suppressed B-cell lymphoma-2 (BCL-2) expression and protein kinase B (AKT) phosphorylation, thereby demonstrating pronounced anti-tumor activity in a mouse model of breast cancer. These findings suggest that OSBP63 represents a promising non-CDN small-molecule STING agonist candidate, offering a valuable lead for future anticancer therapeutic development. |
| WOS关键词 | CGAS ; ACTIVATION ; PATHWAY ; CANCER ; CELLS ; GMP |
| 资助项目 | Nantong Municipal Science and Technology Planning Project[MS2023007] |
| WOS研究方向 | Biochemistry & Molecular Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:001670181300001 |
| 出版者 | MDPI |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/204601]  |
| 专题 | 海洋研究所_实验海洋生物学重点实验室 |
| 通讯作者 | Li, Yunfei; Jiang, Bo |
| 作者单位 | 1.Nantong Zhong Ke Marine Sci & Technol R&D Ctr, Nantong 226334, Peoples R China 2.Chinese Acad Sci, Inst Oceanol, Lab Expt Marine Biol, Qingdao 266000, Peoples R China 3.Tianjin Univ Tradit Chinese Med, Coll Chinese Mat Med, Tianjin 301617, Peoples R China |
| 推荐引用方式 GB/T 7714 | Tang, Manqing,Guo, Qiuhui,Wang, Ping,et al. Marine Bromophenol Derivatives as a Novel Class of Potent Small-Molecule STING Agonists[J]. CURRENT ISSUES IN MOLECULAR BIOLOGY,2026,48(1):15. |
| APA | Tang, Manqing,Guo, Qiuhui,Wang, Ping,Li, Yunfei,&Jiang, Bo.(2026).Marine Bromophenol Derivatives as a Novel Class of Potent Small-Molecule STING Agonists.CURRENT ISSUES IN MOLECULAR BIOLOGY,48(1),15. |
| MLA | Tang, Manqing,et al."Marine Bromophenol Derivatives as a Novel Class of Potent Small-Molecule STING Agonists".CURRENT ISSUES IN MOLECULAR BIOLOGY 48.1(2026):15. |
入库方式： OAI收割
来源：海洋研究所
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