Regulation mechanism of the hadal trench-derived fungus Chaetomium globosum YP-106 under oxygen stress as revealed by integration of metabolomic and transcriptomic profiles
文献类型：期刊论文
| 作者 | Fan, Yaqin2; Liu, Xin2; Zhang, Yan2; Gai, Yuxuan2; Li, Xin1; Song, Lin2 |
| 刊名 | JOURNAL OF OCEANOLOGY AND LIMNOLOGY
 |
| 出版日期 | 2026-02-16 |
| 页码 | 16 |
| 关键词 | metabolomic
transcriptomic
|
| ISSN号 | 2096-5508 |
| DOI | 10.1007/s00343-025-5109-x |
| 通讯作者 | Song, Lin(201601006@qau.edu.cn) |
| 英文摘要 | The sedimentary ecosystems of deep-sea floors harbor abundant biological resources, with fungi emerging as predominant eukaryotic taxa that perform crucial ecological roles. However, the adaptive strategies enabling fungal survival in these extreme low-oxygen environments remain poorly understood. We elucidated the hypoxic adaptation mechanisms of Chaetomium globosum YP-106, an oxygen-sensitive fungus isolated from 6 215-m deep seawater in Yap Trench in the western Pacific. Under hypoxic conditions, the strain growth rate was reduced with significant mycelial morphological alterations. Multi-omics analyses revealed 313 differentially abundant metabolites (DAMs) and 661 differential expression genes (DEGs), enriched in mainly fatty acid metabolism (degradation/synthesis) and carbohydrate utilization pathways. It is noteworthy that gene ontology (GO) enrichment analysis identified 171 membrane-associated genes, suggesting that structural membrane remodeling may serve as a key adaptive strategy. Integrated pathway analysis demonstrated metabolic reprogramming characterized by suppressed tricarboxylic acid (TCA) cycle activity and preferential activation of anaerobic glycolysis for ATP production. Importantly, the NADH dehydrogenase-mediated NAD+ regeneration was enhanced as a compensatory mechanism sustaining residual TCA cycle function. These findings elucidated hypoxic metabolic mechanisms in deep-sea ascomycetes, enhanced our understanding of microbial energy conservation strategies in oxygen-deprived environments, and offered novel perspectives on eukaryotic extremophile adaptation mechanisms in benthic ecosystems. |
| WOS关键词 | DEEP ; HOMEOSTASIS ; EXPRESSION ; HYPOXIA |
| 资助项目 | National Key R&D Program of China[2022YFC2804600] ; National Natural Science Foundation of China[42006096] ; Doctoral Start-Up Fund of Qingdao Agricultural University[663-1117004] ; Horizontal Project: Development of Antarctic Krill Feed for Turbot and Research on Nutrition and Disease Resistance[H20220193] |
| WOS研究方向 | Marine & Freshwater Biology ; Oceanography |
| 语种 | 英语 |
| WOS记录号 | WOS:001691038400001 |
| 出版者 | SCIENCE PRESS |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/204736]  |
| 专题 | 海洋研究所_实验海洋生物学重点实验室 |
| 通讯作者 | Song, Lin |
| 作者单位 | 1.Chinese Acad Sci, Inst Oceanol, CAS & Shandong Prov Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 2.Qingdao Agr Univ, Sch Life Sci, Qingdao 266109, Peoples R China |
| 推荐引用方式 GB/T 7714 | Fan, Yaqin,Liu, Xin,Zhang, Yan,et al. Regulation mechanism of the hadal trench-derived fungus Chaetomium globosum YP-106 under oxygen stress as revealed by integration of metabolomic and transcriptomic profiles[J]. JOURNAL OF OCEANOLOGY AND LIMNOLOGY,2026:16. |
| APA | Fan, Yaqin,Liu, Xin,Zhang, Yan,Gai, Yuxuan,Li, Xin,&Song, Lin.(2026).Regulation mechanism of the hadal trench-derived fungus Chaetomium globosum YP-106 under oxygen stress as revealed by integration of metabolomic and transcriptomic profiles.JOURNAL OF OCEANOLOGY AND LIMNOLOGY,16. |
| MLA | Fan, Yaqin,et al."Regulation mechanism of the hadal trench-derived fungus Chaetomium globosum YP-106 under oxygen stress as revealed by integration of metabolomic and transcriptomic profiles".JOURNAL OF OCEANOLOGY AND LIMNOLOGY (2026):16. |
入库方式： OAI收割
来源：海洋研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。