High-performance droplet electricity generator biosensor for DNA detection
文献类型：期刊论文
| 作者 | Liu, Yitong1,4; Zhou, Yanan1,4; Wu, Jiajia1,4; Wang, Peng1,2,4; Wang, Congyu4; Jiang, Wenyong4; Sun, Shao'e1,3,5,6; Wang, Jianming1,4; Zhang, Dun1,4; Sha, Zhongli1,3,5,6 |
| 刊名 | CELL REPORTS PHYSICAL SCIENCE
 |
| 出版日期 | 2026-02-18 |
| 卷号 | 7期号:2页码:16 |
| DOI | 10.1016/j.xcrp.2025.103091 |
| 通讯作者 | Wang, Peng(wangpeng@qdio.ac.cn) ; Sha, Zhongli(shazl@qdio.ac.cn) |
| 英文摘要 | Droplet electricity generator (DEG)-powered DNA biosensors offer significant advantages in ultrasensitive and portable detection. However, the suboptimal power output of conventional DEGs has hindered the advancement of their sensing performance. To address this limitation, we engineered a core-shell-structured high-entropy sulfide (HES)-based filler to construct an optimized intermediate layer for the DEG (TiO2 @HES/ PVDF [THP]-DEG), achieving a remarkable output voltage of 625 V and dramatically improving the detection limit of the DEG biosensor. Specifically, the research developed a THP composite as the functional intermediate layer, where the advanced material design effectively mitigates particle aggregation and leakage current, thereby enhancing sensor performance and extending the DNA detection range to the femtomolar (fM) level. Furthermore, we established a mathematical model to precisely correlate electrical signals with DNA concentration. The THP-DEG biosensor demonstrated exceptional performance in detecting DNA from Alvinocarididae and sulfate-reducing bacteria, achieving ultrahigh sensitivity with detection limits of 0.987 and 0.927 fM, respectively. |
| WOS关键词 | ADSORPTION |
| 资助项目 | National Science Foundation of China (NSFC) for Distinguished Young Scholars[42025603] ; Natural Science Foundation of Guangxi[2023GXNSFDA026059] ; Natural Science Foundation of Guangxi[GuikeAD24010036] ; National Natural Science Foundation of China[42276216] ; Nantong Natural Science Foundation[JC2023084] ; Qingdao Science and Technology Plan Project[24-1-3-hygg-16-hy] |
| WOS研究方向 | Chemistry ; Energy & Fuels ; Materials Science ; Physics |
| 语种 | 英语 |
| WOS记录号 | WOS:001697144600001 |
| 出版者 | CELL PRESS |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/204826]  |
| 专题 | 海洋研究所_实验海洋生物学重点实验室 |
| 通讯作者 | Wang, Peng; Sha, Zhongli |
| 作者单位 | 1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 2.Guangxi Acad Sci, Inst Marine Corros Protect, Guangxi Acad Marine Sci, Guangxi Key Lab Marine Environm Sci, Nanning 530007, Peoples R China 3.Laoshan Lab, Qingdao 266237, Peoples R China 4.Chinese Acad Sci, Inst Oceanol, State Key Lab Adv Marine Mat, Qingdao 266071, Peoples R China 5.Chinese Acad Sci, Inst Oceanol, Dept Marine Organism Taxon & Phylogeny, Qingdao 266071, Peoples R China 6.Chinese Acad Sci, Inst Oceanol, Shandong Prov Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Yitong,Zhou, Yanan,Wu, Jiajia,et al. High-performance droplet electricity generator biosensor for DNA detection[J]. CELL REPORTS PHYSICAL SCIENCE,2026,7(2):16. |
| APA | Liu, Yitong.,Zhou, Yanan.,Wu, Jiajia.,Wang, Peng.,Wang, Congyu.,...&Sha, Zhongli.(2026).High-performance droplet electricity generator biosensor for DNA detection.CELL REPORTS PHYSICAL SCIENCE,7(2),16. |
| MLA | Liu, Yitong,et al."High-performance droplet electricity generator biosensor for DNA detection".CELL REPORTS PHYSICAL SCIENCE 7.2(2026):16. |
入库方式： OAI收割
来源：海洋研究所
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