Immunomodulatory activity exploratory of riched gamma-aminobutyric acid gamma-aminobutyric acid in fermentated scallop skirt
文献类型：期刊论文
| 作者 | Yang, Haoyue1,2; Xing, Ronge1,2; Li, Kecheng1,2; Yu, Huahua1,2; Li, Pengcheng1,2; Liu, Song1,2 |
| 刊名 | JOURNAL OF MICROBIOLOGICAL METHODS
 |
| 出版日期 | 2026-04-01 |
| 卷号 | 243页码:9 |
| 关键词 | Scallop skirt Microbial transformation GABA Immune regulation |
| ISSN号 | 0167-7012 |
| DOI | 10.1016/j.mimet.2026.107443 |
| 通讯作者 | Xing, Ronge(xingronge@qdio.ac.cn) |
| 英文摘要 | Scallops belong to the Pectinidae family of the Mollusca phylum and are a major economic shellfish in ocean. With the rapid growth of shellfish aquaculture, the processing size of scallops has also increased significantly. During the processing of scallop, a large amount of scallop byproducts are generated, including the mantle (skirt) and viscera. Glutamic acid (Glu) is a main amino acid in scallops and the substrate for the produce of gamma-aminobutyric acid (GABA), which is an important inhibitory neurotransmitter in the central nervous system (CNS). Therefore, finding low-cost raw materials for efficient microbial production of GABA is a key issue to solve the problems of large-scale production and application of food-grade GABA. This study aimed to replace the nutrients in traditional culture media by enzymatic hydrolysis and blending of scallop skirts, which induce lactic acid bacteria to highly express glutamic acid decarboxylase (GAD) to convert Glu into GABA via optimal environmental factors. In addition, the regulatory effect of GABA on the immune activity of macrophages also is to solve the problems of complex preparation processes and high costs of traditional culture media, while increasing the content and edible safety of GABA products. This method provides new insights into the immune regulatory functions of small molecule metabolites in the immune system, in addition to cytokines and membrane proteins. |
| 资助项目 | Key R & D Program (Major Scientific and Technological Innovation Project) of Shandong Province, China[2022CXGC020413] ; Taishan Industrial Experts Program ; Na-tional Natural Science Foundation of China[42276097] ; Natural Science Foundation of Shandong Province[ZR2022YQ37] ; Modern Agro-industry Technology Research System[CARS-49] ; Central Guid-ance for Local Scientific and Technological Development Funds[2024ZY0039] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Microbiology |
| 语种 | 英语 |
| WOS记录号 | WOS:001706447800001 |
| 出版者 | ELSEVIER |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/204853]  |
| 专题 | 海洋研究所_实验海洋生物学重点实验室 |
| 通讯作者 | Xing, Ronge |
| 作者单位 | 1.Chinese Acad Sci, Inst Oceanol, Lab Expt Marine Biol, Qingdao 266000, Shandong, Peoples R China 2.Qingdao Marine Sci & Technol Ctr, Lab Marine Drugs & Bioprod, Qingdao 266237, Shandong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yang, Haoyue,Xing, Ronge,Li, Kecheng,et al. Immunomodulatory activity exploratory of riched gamma-aminobutyric acid gamma-aminobutyric acid in fermentated scallop skirt[J]. JOURNAL OF MICROBIOLOGICAL METHODS,2026,243:9. |
| APA | Yang, Haoyue,Xing, Ronge,Li, Kecheng,Yu, Huahua,Li, Pengcheng,&Liu, Song.(2026).Immunomodulatory activity exploratory of riched gamma-aminobutyric acid gamma-aminobutyric acid in fermentated scallop skirt.JOURNAL OF MICROBIOLOGICAL METHODS,243,9. |
| MLA | Yang, Haoyue,et al."Immunomodulatory activity exploratory of riched gamma-aminobutyric acid gamma-aminobutyric acid in fermentated scallop skirt".JOURNAL OF MICROBIOLOGICAL METHODS 243(2026):9. |
入库方式： OAI收割
来源：海洋研究所
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