中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 海洋研究所
  3. 中国科学院海洋研究所
  4. 实验海洋生物学重点实验室
Fusarielins Q-Y: fusarielin polyketides from Fusarium asiaticum QA-6 inhabiting the roots of the cultivated Artemisia argyi and their antibacterial activity against aquatic pathogens

文献类型：期刊论文

作者Shi, Xiao-Shan1,2,4,5; Yang, Sui-Qun1,4,5; Dong, Yu-Liang1,4,5; Li, Xiao-Ming1,4,5; Meng, Ling-Hong1,3,4,5; Li, Yan-He1,4,5; Wang, Dun-Jia2; Zhou, Xing-Wang2; Wang, Bin-Gui1,3,4,5
刊名PHYTOCHEMISTRY
出版日期2026-08-01
卷号248页码:10
关键词Artemisia argyi Asteraceae Fusarium asiaticum Nectriaceae Fusarielins Polyketides Antibacterial activity
ISSN号0031-9422
DOI10.1016/j.phytochem.2026.114908
通讯作者Zhou, Xing-Wang(zhouxw@hbnu.edu.cn) ; Wang, Bin-Gui(wangbg@ms.qdio.ac.cn)
英文摘要Artemisia argyi Levl. et Van. var. argyi cv. Qiai is a commercially important medicinal plant specifically cultivated in Qichun County, Hubei Province of Central China. Investigation of the antibacterial functional constituents of the endophytic Fusarium asiaticum QA-6, which is derived from Qiai, resulted in the characterization of nine previously undescribed polyketides fusarielins Q-Y (compounds 1-9) and two known congeners fusarielins M (compound 10) and F (compound 11). Structurally, compounds 1-9 possess a highly functionalized decalin moiety, whereas compounds 1-3 feature shorter polyene side chains compared to other fusarielins. The shortened chain in 2 and 3 likely results from a missed S-adenosyl-L-methionine (SAM)-dependent methylation, with 3 being an oxidation product of 2. Conversely, the truncation in 1 may stem from a missed acetyl-CoA addition. The isolated compounds were assayed for antibacterial activity against aquatic bacterial pathogens, among which, compounds 1, 5, 10, and 11 exhibited activity against specific Gram-negative strains, with compound 1 inhibited Aeromonas hydrophilia (MIC = 2.92 & micro;M) and Vibrio alginolyticus (MIC = 5.84 & micro;M), compound5 targeted the aquatic pathogen Edwardsiella ictarda (MIC = 2.39 & micro;M), compound 10 acted against E. ictarda, Vibrio harveyi, and V. parahaemolyticus (each with an MIC value of 2.60 & micro;M), and compound 11 inhibited V. alginolyticus (MIC = 4.80 & micro;M). All these antibacterial activities were equivalent to or superior to those of the positive control, chloramphenicol (MICs = 1.55 to 6.19 & micro;M). In the preliminary screening against HeLa cells, none of the isolated compounds exhibited significant cytotoxic activity at the concentration 20 & micro;M.
资助项目Natural Science Foundation of China[32100320] ; Natural Science Foundation of Hubei Province[2022CFB503]
WOS研究方向Biochemistry & Molecular Biology ; Plant Sciences
语种英语
WOS记录号WOS:001744876400001
出版者PERGAMON-ELSEVIER SCIENCE LTD
源URL[http://ir.qdio.ac.cn/handle/337002/204922]  
专题海洋研究所_实验海洋生物学重点实验室
通讯作者Zhou, Xing-Wang; Wang, Bin-Gui
作者单位1.Qingdao Marine Sci & Technol Ctr, Lab Marine Biol & Biotechnol, Nanhai Rd 7, Qingdao 266071, Peoples R China
2.Hubei Normal Univ, Hubei Engn Res Ctr Characterist Wild Vegetable Bre, Hubei Key Lab Edible Wild Plants Conservat & Utili, Huangshi Key Lab Lake Environm Protect & Sustainab, Cihu Rd 11, Huangshi 435002, Peoples R China
3.Univ Chinese Acad Sci, Yuquan Rd 19A, Beijing 100049, Peoples R China
4.Chinese Acad Sci, Inst Oceanol, Shandong Prov Key Lab Expt Marine Biol, Nanhai Rd 7, Qingdao 266071, Peoples R China
5.Chinese Acad Sci, Nanhai Rd 7, Qingdao 266071, Peoples R China
推荐引用方式
GB/T 7714		 Shi, Xiao-Shan,Yang, Sui-Qun,Dong, Yu-Liang,et al. Fusarielins Q-Y: fusarielin polyketides from Fusarium asiaticum QA-6 inhabiting the roots of the cultivated Artemisia argyi and their antibacterial activity against aquatic pathogens[J]. PHYTOCHEMISTRY,2026,248:10.
APA Shi, Xiao-Shan.,Yang, Sui-Qun.,Dong, Yu-Liang.,Li, Xiao-Ming.,Meng, Ling-Hong.,...&Wang, Bin-Gui.(2026).Fusarielins Q-Y: fusarielin polyketides from Fusarium asiaticum QA-6 inhabiting the roots of the cultivated Artemisia argyi and their antibacterial activity against aquatic pathogens.PHYTOCHEMISTRY,248,10.
MLA Shi, Xiao-Shan,et al."Fusarielins Q-Y: fusarielin polyketides from Fusarium asiaticum QA-6 inhabiting the roots of the cultivated Artemisia argyi and their antibacterial activity against aquatic pathogens".PHYTOCHEMISTRY 248(2026):10.

入库方式： OAI收割

来源：海洋研究所

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。