Cis-variation-trans-variation interactions between Hsp90 promoters shape G × E effects and underlie divergent phenotypic thermal adaptation plasticity in two congeneric oyster species
文献类型：期刊论文
| 作者 | Jiang, Zhuxiang3,8; Wang, Chaogang5,7; Du, Mingyang8; Cong, Rihao1,2,4,5; Li, Ao1,3,4,5,8; Wang, Wei5,6,7; Zhang, Guofan1,2,3,4,5; Li, Li1,2,3,5,6,7,8 |
| 刊名 | MARINE LIFE SCIENCE & TECHNOLOGY
 |
| 出版日期 | 2026-03-31 |
| 页码 | 13 |
| 关键词 | Phenotypic plasticity
Temperature
G & times
|
| ISSN号 | 2096-6490 |
| DOI | 10.1007/s42995-026-00373-6 |
| 通讯作者 | Li, Li(lili@qdio.ac.cn) |
| 英文摘要 | Global warming may drive adaptive evolution by influencing natural selection and utilizing temperature-related phenotypic plasticity. However, predicting the evolutionary patterns of phenotypic plasticity under climate change remains a challenge, underscoring the need to elaborate on the underlying genetic and molecular mechanisms. In this study, we focus on the expression plasticity divergence of heat shock protein 90 (Hsp90), which is temperature responsive and exhibits a strong selective sweep in the upstream noncoding region of two allopatric congeneric oyster species: cold-adapted Crassostrea gigas and warm-adapted Crassostrea angulata. Functional characterization confirmed Hsp90 expression as an ideal proxy for thermotolerance. The evolutionary divergence in constitutive and plastic expression patterns represents adaptation to the mean and variance in habitat temperature, respectively. By combining forward and reverse genetic approaches, four causative loci with G + G & times; E effects were identified in the Hsp90 promoter regions of C. gigas and C. angulata, indicating cis-variations. Moreover, the g.-2291G allele of the causative locus in C. angulata is specifically bound to by the positive transcription factor purine-rich element binding protein B (PURB), explaining the constitutive expression of Hsp90. Meanwhile, the response of PURB to thermal stress determines the magnitude of plastic Hsp90 expression in C. angulata. This integrative study revealed that cis-variations interact with trans-variations and underlie the G & times; E effect under environmental changes, thereby mediating the divergence in plastic gene expression. Furthermore, we established a paradigm for studying genetic variants and their G & times; E impacts at a finer resolution, i.e., single-nucleotide level, in nonmodel organisms. The findings may deepen our understanding of the significant role of phenotypic plasticity in modulating adaptive responses and promote predictions of adaptive potential in marine organisms under climate change. |
| WOS关键词 | RESPONSIVE GENE-EXPRESSION ; HEAT-SHOCK RESPONSE ; LOCAL ADAPTATION ; MOLECULAR-MECHANISMS ; CLIMATE ; CLASSIFICATION ; EVOLUTION ; PATTERNS |
| 资助项目 | National Key R&D Program of China[2022YFD2400304] ; Key Research and Development Program of Shandong[ZFJH202309] ; China Agriculture Research System of MOF[CARS-49] ; Postdoctoral Fellowship Program (Grade B) of China Postdoctoral Science Foundation[GZB20250723] ; Taishan Scholars Program[tsqn202312267] ; Youth Innovation Promotion Association, Chinese Academy of Sciences[2023215] ; China Postdoctoral Science Foundation[2025M770875] ; Department of Science & Technology of Shandong Province[2022GJJLJRC02-096] |
| WOS研究方向 | Marine & Freshwater Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:001730169500001 |
| 出版者 | SPRINGERNATURE |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/205066]  |
| 专题 | 海洋研究所_实验海洋生物学重点实验室 |
| 通讯作者 | Li, Li |
| 作者单位 | 1.Oyster Ind Technol Inst Zhanjiang, Southern Marine Sci & Engn Guangdong Lab Zhanjiang, Zhanjiang 524057, Peoples R China 2.Shandong Ctr Technol Innovat Oyster Seed Ind, Qingdao 266105, Peoples R China 3.Chinese Acad Sci, Inst Oceanol, State Key Lab Breeding Biotechnol & Sustainable Aq, Qingdao 266237, Peoples R China 4.Qingdao Marine Sci & Technol Ctr, Lab Marine Biol & Biotechnol, Qingdao 266237, Peoples R China 5.Chinese Acad Sci, Inst Oceanol, Lab Expt Marine Biol, Qingdao 266237, Peoples R China 6.Qingdao Marine Sci & Technol Ctr, Lab Marine Fisheries Sci & Food Prod Proc, Qingdao 266237, Peoples R China 7.Natl & Local Joint Engn Lab Ecol Mariculture, Qingdao 266071, Peoples R China 8.Univ Chinese Acad Sci, Beijing 101408, Peoples R China |
| 推荐引用方式 GB/T 7714 | Jiang, Zhuxiang,Wang, Chaogang,Du, Mingyang,et al. Cis-variation-trans-variation interactions between Hsp90 promoters shape G × E effects and underlie divergent phenotypic thermal adaptation plasticity in two congeneric oyster species[J]. MARINE LIFE SCIENCE & TECHNOLOGY,2026:13. |
| APA | Jiang, Zhuxiang.,Wang, Chaogang.,Du, Mingyang.,Cong, Rihao.,Li, Ao.,...&Li, Li.(2026).Cis-variation-trans-variation interactions between Hsp90 promoters shape G × E effects and underlie divergent phenotypic thermal adaptation plasticity in two congeneric oyster species.MARINE LIFE SCIENCE & TECHNOLOGY,13. |
| MLA | Jiang, Zhuxiang,et al."Cis-variation-trans-variation interactions between Hsp90 promoters shape G × E effects and underlie divergent phenotypic thermal adaptation plasticity in two congeneric oyster species".MARINE LIFE SCIENCE & TECHNOLOGY (2026):13. |
入库方式： OAI收割
来源：海洋研究所
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