Synergistic induction of immunogenic cell death and tumor microenvironment remodeling by biotinylated marine polysaccharide nanoparticles for enhanced colorectal cancer therapy
文献类型：期刊论文
| 作者 | Wang, Hui2,3; Yu, Haoyu2,3; Yang, Yan2; Fu, Mengying2,3; Geng, Lihua2,3; Wang, Jing2,3; Yue, Yang2,3; Zhang, Quanbin2,3; Wu, Ning1,2,3,4 |
| 刊名 | CARBOHYDRATE POLYMERS
 |
| 出版日期 | 2026-06-01 |
| 卷号 | 381页码:20 |
| 关键词 | Chitosan Fucoidan Polysaccharide nanoparticles Dual-targeting Tumor microenvironment |
| ISSN号 | 0144-8617 |
| DOI | 10.1016/j.carbpol.2026.125185 |
| 通讯作者 | Wu, Ning(wuning@qdio.ac.cn) |
| 英文摘要 | Tumor heterogeneity, immunosuppression, and frequent adverse effects present major challenges in colorectal cancer therapy. Although the combination of oxaliplatin (OXA, chemotherapy) and fruquintinib (FRU, antiangiogenic) shows clinical promise, their divergent physicochemical properties and inadequate tumor selectivity lead to suboptimal efficacy and systemic toxicity. To overcome the challenge, we developed a tumor-targeted nanosystem based on chitosan and fucoidan for co-delivery of hydrophilic oxaliplatin and hydrophobic fruquintinib (CS-Arg/Fuc-Bio@OF). The nanoparticle leverages the inherent P-selectin affinity of fucoidan and active targeting given by biotin modification to achieve precise tumor accumulation and microenvironment-responsive drug release. In vitro studies demonstrated that CS-Arg/Fuc-Bio@OF effectively eliminated HCT116 and HT29 cancer cells by inducing robust immunogenic cell death (ICD) and exerted potent anti-angiogenic effects. The combination of OXA-induced ICD with FRU-mediated angiogenesis suppression and polysaccharide-promoted immunomodulation synergistically reprogrammed the immunosuppressive tumor microenvironment, facilitating an effective anti-tumor immune response. In vivo, the nanoparticles significantly inhibited tumor growth and demonstrated good biosafety, with a hemolysis rate < 5% and no appreciable organ toxicity observed. This work not only validates CS-Arg/Fuc-Bio@OF as an efficient and safe combination therapy carrier but also provides a novel strategy for developing drug delivery systems based on natural polysaccharides. |
| WOS关键词 | OXALIPLATIN ; FRUQUINTINIB ; METASTASIS ; PLATELETS ; KRAS |
| 资助项目 | National Natural Science Foundation of China[32201049] ; Natural Science Foundation of Nantong Municipality[JC2023088] ; Special Fund for Innovation-Driven Development in Guangxi[JF2503980038] ; Qingdao West Coast New District University Presidents Fund[E42424101N] |
| WOS研究方向 | Chemistry ; Polymer Science |
| 语种 | 英语 |
| WOS记录号 | WOS:001716120500001 |
| 出版者 | ELSEVIER SCI LTD |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/205091]  |
| 专题 | 海洋研究所_实验海洋生物学重点实验室 |
| 通讯作者 | Wu, Ning |
| 作者单位 | 1.Qingdao Marine Sci & Technol Ctr, Lab Marine Drugs & Bioprod, Qingdao 266237, Peoples R China 2.Chinese Acad Sci, Inst Oceanol, CAS & Shandong Prov Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.China Nantong Zhongke Marine Sci & Technol Res & D, Nantong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Hui,Yu, Haoyu,Yang, Yan,et al. Synergistic induction of immunogenic cell death and tumor microenvironment remodeling by biotinylated marine polysaccharide nanoparticles for enhanced colorectal cancer therapy[J]. CARBOHYDRATE POLYMERS,2026,381:20. |
| APA | Wang, Hui.,Yu, Haoyu.,Yang, Yan.,Fu, Mengying.,Geng, Lihua.,...&Wu, Ning.(2026).Synergistic induction of immunogenic cell death and tumor microenvironment remodeling by biotinylated marine polysaccharide nanoparticles for enhanced colorectal cancer therapy.CARBOHYDRATE POLYMERS,381,20. |
| MLA | Wang, Hui,et al."Synergistic induction of immunogenic cell death and tumor microenvironment remodeling by biotinylated marine polysaccharide nanoparticles for enhanced colorectal cancer therapy".CARBOHYDRATE POLYMERS 381(2026):20. |
入库方式： OAI收割
来源：海洋研究所
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