High hydrostatic pressure modulates copper and cadmium accumulation and biomarker responses in Modiolus kurilensis: Implications for deep-sea mining risk assessment
文献类型：期刊论文
| 作者 | Zhou, Li5,6; Zhong, Zhaoshan6; Lian, Chao6; He, Yameng1,3,5; Wang, Minxiao5,6; Chen, Hao6; Fu, Lulu6; Ma, Manman6; Sun, Yan4; Li, Chaolun1,2,3,5 |
| 刊名 | ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
 |
| 出版日期 | 2025-11-15 |
| 卷号 | 307页码:11 |
| 关键词 | Deep-sea mining Mussels Metals Biomarkers High hydrostatic pressure |
| ISSN号 | 0147-6513 |
| DOI | 10.1016/j.ecoenv.2025.119448 |
| 通讯作者 | Zhou, Li(lizhou@qdio.ac.cn) ; Li, Chaolun(lcl@qdio.ac.cn) |
| 英文摘要 | As deep-sea mining approaches commercial implementation, evaluating contaminant risks under realistic environmental conditions-particularly high hydrostatic pressure (HP)-has become increasingly critical. Yet, most existing toxicological studies are conducted under atmospheric pressure, potentially overlooking pressure-induced modifications in metal behavior and biological response. In this 48-hour exposure study, we used the coastal mussel Modiolus kurilensis, a close relative of deep-sea Bathymodiolins, to investigate its biological responses to copper (Cu) and cadmium (Cd) exposure (100 mu g/L) under both atmospheric and simulated deep-sea pressure. We assessed metal accumulation and 13 traditional metal-related biochemical biomarkers across gill, mantle, and visceral mass. Results showed that HP significantly reshaped metal accumulation in a tissue-and metal-specific manner, enhancing Cu and Cd uptake in gill and mantle, and selectively promoting Cd retention in visceral mass. Correspondingly, HP reprogrammed biochemical responses: mantle reactivity was suppressed, gill detoxification intensified, and visceral mass shifted toward lipid oxidative damage and metabolic disruption. Critically, by comparing responses across both pressure conditions, we identified two pressure-insensitive biomarkers-acid phosphatase and hexokinase in the mantle-that consistently responded to metal exposure regardless of pressure. These biomarkers hold strong potential for pressure-independent biomonitoring. In contrast, many conventional biomarkers showed divergent responses under HP, highlighting the risk of misinterpretation if pressure effects are ignored. Our study offers a pressure-aware framework for deep-sea ecotoxicology using coastal proxies and provides essential guidance for selecting reliable biomarkers for future environmental risk assessments of deep-sea mining. |
| WOS关键词 | METAL CONCENTRATIONS ; TOXICITY INSIGHTS ; OKINAWA TROUGH ; SHALLOW-WATER ; MUSSEL ; TEMPERATURE ; IMPACTS ; FIELD ; CU |
| 资助项目 | National Key R&D Program of China[2022YFC2804003] ; National Key R&D Program of China[2024YFC2816000] ; National Natural Science Foundation of China[42576149] ; National Natural Science Foundation of China[42276153] ; National Natural Science Foundation of China[42476101] ; Chinese Academy of Sciences Technical Support Talent Program (Project: Development of Key Technologies for High-Pressure Biological Cultivation and Authentic Sample Acquisition)[E3KY091] ; NSFC Innovative Group Grant[42221005] ; Natural Science Foundation of Shandong Province[ZR2024MD029] ; Oceanographic Data Center, IOCAS |
| WOS研究方向 | Environmental Sciences & Ecology ; Toxicology |
| 语种 | 英语 |
| WOS记录号 | WOS:001629738400004 |
| 出版者 | ACADEMIC PRESS INC ELSEVIER SCIENCE |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/204363]  |
| 专题 | 海洋研究所_海洋生态与环境科学重点实验室 |
| 通讯作者 | Zhou, Li; Li, Chaolun |
| 作者单位 | 1.Guangdong Prov Key Lab Appl Marine Biol, Guangzhou, Peoples R China 2.Laoshan Lab, Qingdao 266237, Peoples R China 3.Chinese Acad Sci, South China Sea Inst Oceanol, State Key Lab Trop Oceanog, Guangzhou, Peoples R China 4.Chinese Acad Sci, Inst Oceanol, CAS Key Lab Marine Ecol & Environm Sci, Qingdao 266071, Peoples R China 5.Univ Chinese Acad Sci, Beijing, Peoples R China 6.Chinese Acad Sci, Inst Oceanol, Ctr Deep Sea Res, Qingdao 266071, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhou, Li,Zhong, Zhaoshan,Lian, Chao,et al. High hydrostatic pressure modulates copper and cadmium accumulation and biomarker responses in Modiolus kurilensis: Implications for deep-sea mining risk assessment[J]. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,2025,307:11. |
| APA | Zhou, Li.,Zhong, Zhaoshan.,Lian, Chao.,He, Yameng.,Wang, Minxiao.,...&Li, Chaolun.(2025).High hydrostatic pressure modulates copper and cadmium accumulation and biomarker responses in Modiolus kurilensis: Implications for deep-sea mining risk assessment.ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,307,11. |
| MLA | Zhou, Li,et al."High hydrostatic pressure modulates copper and cadmium accumulation and biomarker responses in Modiolus kurilensis: Implications for deep-sea mining risk assessment".ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY 307(2025):11. |
入库方式： OAI收割
来源：海洋研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。