Hematopoietic and immune homeostasis programs of the Polian vesicle after evisceration in Apostichopus japonicus
文献类型：期刊论文
| 作者 | Wu, Qianwen1,2,4,5; Cui, Wei1,2,4,5; Jiang, Chunxi1,2,4,5; Sun, Lina1,2,4,5; Feng, Qiming3; Su, Fang1,2,4,5 |
| 刊名 | COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY
 |
| 出版日期 | 2026-02-01 |
| 卷号 | 312页码:11 |
| 关键词 | Apostichopus japonicus Polian vesicles Hematopoiesis Regeneration Immune homeostasis |
| ISSN号 | 1095-6433 |
| DOI | 10.1016/j.cbpa.2025.111964 |
| 通讯作者 | Su, Fang(sufang@qdio.ac.cn) |
| 英文摘要 | Polian vesicles (PVs) are key components of the water vascular system in sea cucumbers, functioning in hematopoiesis and immune defense, and notably remaining as the sole organs within the coelomic cavity after evisceration. To elucidate how accessory water-vascular organs participate in visceral regeneration, we performed time-resolved transcriptome profiling of PVs collected at early post-evisceration stages (at 6 h, 1 day, 3 days, and 7 days post-evisceration) in Apostichopus japonicus. Our study reveals a highly dynamic and sequential regulatory process, characterized by an acute transcriptional response transitioning to stabilized remodeling. The number of differentially expressed genes (DEGs) peaked at the early stage (6 hpe) and subsequently declined. At 6 hpe, pathways for metabolic activation and DNA replication predominated. During 1-3 dpe, signals shifted to structural reconstruction and immune activation. By 7 dpe, modules linked to immune homeostasis and functional recovery. Notably, ECM remodeling and signal transduction were sustained. Network analysis highlighted key gene modules and hub genes driving each distinct regenerative stages. Collectively, our results position the PV as a dynamic regulatory hub that supports early visceral regeneration by coupling hematopoietic output with tissue-repair signaling. |
| WOS关键词 | SEA-CUCUMBER ; REGENERATION ; RECOGNITION ; CELOMOCYTES |
| 资助项目 | Key Research and Development Program of Shandong[2023LZGC019] ; Shandong Provincial Natural Science Foundation[ZR2024YQ050] ; Taishan Scholars Program[tsqn202306279] ; China Postdoctoral Science Foundation[2025M770873] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Physiology ; Zoology |
| 语种 | 英语 |
| WOS记录号 | WOS:001647889000001 |
| 出版者 | ELSEVIER SCIENCE INC |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/204520]  |
| 专题 | 海洋研究所_海洋生态与环境科学重点实验室 |
| 通讯作者 | Su, Fang |
| 作者单位 | 1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 2.Chinese Acad Sci, Inst Oceanol, Key Lab Marine Ecol & Environm Sci, Qingdao 266000, Peoples R China 3.Qingdao West Coast New Area Marine Dev Bur, Qingdao 266400, Peoples R China 4.Chinese Acad Sci, Inst Oceanol, State Key Lab Breeding Biotechnol & Sustainable Aq, Qingdao 266000, Peoples R China 5.Qingdao Marine Sci & Technol Ctr, Lab Marine Ecol & Environm Sci, Qingdao 266237, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wu, Qianwen,Cui, Wei,Jiang, Chunxi,et al. Hematopoietic and immune homeostasis programs of the Polian vesicle after evisceration in Apostichopus japonicus[J]. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY,2026,312:11. |
| APA | Wu, Qianwen,Cui, Wei,Jiang, Chunxi,Sun, Lina,Feng, Qiming,&Su, Fang.(2026).Hematopoietic and immune homeostasis programs of the Polian vesicle after evisceration in Apostichopus japonicus.COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY,312,11. |
| MLA | Wu, Qianwen,et al."Hematopoietic and immune homeostasis programs of the Polian vesicle after evisceration in Apostichopus japonicus".COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY 312(2026):11. |
入库方式： OAI收割
来源：海洋研究所
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