中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 海洋研究所
  3. 中国科学院海洋研究所
  4. 海洋生态与环境科学重点实验室
pCO2-induced seawater acidification influencing cadmium toxicity on antioxidant defenses responses in juvenile Manila clam Ruditapes philippinarum

文献类型：期刊论文

作者Ni, Zhilin1,4; Cui, Wenting2; Liu, Jinhu3,4,5; Cao, Liang4,5; Dou, Shuozeng1,4,5
刊名MARINE POLLUTION BULLETIN
出版日期2026-07-01
卷号228页码:12
关键词Ocean acidification Heavy metal Oxidative stress Antioxidant biomarkers Shellfish or molluscs
ISSN号0025-326X
DOI10.1016/j.marpolbul.2026.119624
通讯作者Dou, Shuozeng(szdou@qdio.ac.cn)
英文摘要Ocean acidification is known to interact with heavy metals, impacting physiological processes of marine organisms. This study investigated antioxidant defenses of juvenile Manila clam Ruditapes philippinarum exposed to cadmium (Cd) across ambient-relevant to high concentrations, underpCO2-induced seawater acidification (SA) scenarios corresponding to IPCC ocean pH projections. Results revealed that clam's antioxidant system, encompassing GSH defense system and SOD-CAT defense lines, collectively combated oxidative stress dependent on specific stressors and their stress levels. GSH system is vital for detoxification and maintaining redox balance, while SOD and CAT are essential for scavenging ROS. Cd exposure notably activated GSH redox cycle, and SA markedly inhibited the antioxidants associated with this cycle. SOD and CAT exhibited distinct regulatory pathways with asynchronous responses to SA and Cd co-exposure. SA conditions modulate Cd-induced antioxidant response dependent on metal concentrations. Antioxidant biomarkers responded more prominently to SA and Cd interactions than to individual exposure, particularly, high SA effects could override Cd effects on antioxidant responses. Although SA effects did not directly induce lipid peroxidation, elevated MDA levels under Cd exposure occurred only under SA conditions, indicating insufficient antioxidant defense against lipid per-oxidation under excess co-exposure. GSH and SOD were more sensitive to SA exposure, whereas MDA and GST were sensitive to Cd exposure, suggesting their potential as biomarkers for assessing SA or Cd-induced oxidative stress, respectively. These findings provide insights into interplay between metal toxicity and ocean acidification on antioxidant defenses in bivalves, shedding light on their strategies to combat metal pollution amidst global ocean change.
WOS关键词OCEAN ACIDIFICATION ; OXIDATIVE STRESS ; CRASSOSTREA-VIRGINICA ; LIPID-PEROXIDATION ; METAL ; GLUTATHIONE ; BIOACCUMULATION ; HEPATOPANCREAS ; CALCIFICATION ; PATHWAYS
资助项目National Key Basic Research Program[2015CB453302]
WOS研究方向Environmental Sciences & Ecology ; Marine & Freshwater Biology
语种英语
WOS记录号WOS:001730256200001
出版者PERGAMON-ELSEVIER SCIENCE LTD
源URL[http://ir.qdio.ac.cn/handle/337002/205048]  
专题海洋研究所_海洋生态与环境科学重点实验室
通讯作者Dou, Shuozeng
作者单位1.Univ Chinese Acad Sci, Beijing 100039, Peoples R China
2.Tianjin Agr Univ, Fisheries Coll, Tianjin 300380, Peoples R China
3.Shandong Prov Key Lab Marine Biodivers & Bioresour, Qingdao 266071, Peoples R China
4.Chinese Acad Sci, Inst Oceanol, Lab Marine Ecol & Environm Sci, Qingdao 266071, Peoples R China
5.Qingdao Marine Sci & Technol Ctr, Lab Marine Ecol & Environm Sci, Qingdao 266237, Peoples R China
推荐引用方式
GB/T 7714		 Ni, Zhilin,Cui, Wenting,Liu, Jinhu,et al. pCO2-induced seawater acidification influencing cadmium toxicity on antioxidant defenses responses in juvenile Manila clam Ruditapes philippinarum[J]. MARINE POLLUTION BULLETIN,2026,228:12.
APA Ni, Zhilin,Cui, Wenting,Liu, Jinhu,Cao, Liang,&Dou, Shuozeng.(2026).pCO2-induced seawater acidification influencing cadmium toxicity on antioxidant defenses responses in juvenile Manila clam Ruditapes philippinarum.MARINE POLLUTION BULLETIN,228,12.
MLA Ni, Zhilin,et al."pCO2-induced seawater acidification influencing cadmium toxicity on antioxidant defenses responses in juvenile Manila clam Ruditapes philippinarum".MARINE POLLUTION BULLETIN 228(2026):12.

入库方式： OAI收割

来源：海洋研究所

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。