Proteomic profiling reveals matrix remodeling and metabolic homeostasis in sea cucumber mutable collagenous tissue
文献类型：期刊论文
| 作者 | Wu, Qianwen1,2,3,4; Su, Fang1,2,3,4; Jiang, Chunxi1,2,3,4; Cui, Wei1,2,3,4; Sun, Lina1,2,3,4 |
| 刊名 | COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY D-GENOMICS & PROTEOMICS
 |
| 出版日期 | 2026-09-01 |
| 卷号 | 59页码:10 |
| 关键词 | Mutable collagenous tissue Sea cucumber Extracellular matrix Juxtaligamental cells Glycosaminoglycans Metabolic homeostasis |
| ISSN号 | 1744-117X |
| DOI | 10.1016/j.cbd.2026.101820 |
| 通讯作者 | Sun, Lina(sunlina@qdio.ac.cn) |
| 英文摘要 | Mutable Collagenous Tissue (MCT) is an echinoderm-specific connective tissue, capable of rapidly altering its mechanical properties under neural regulation. Although several potential effector proteins have been identified, the overall molecular network governing the transition between the stiffened and softened states of MCT remains unclear. To uncover potential mechanisms, we performed iTRAQ-based quantitative proteomics on MCT from Stichopus chloronotus under stiffened and softened conditions. A total of 1653 proteins were identified, with 160 differentially abundant proteins detected between stiffened and softened tissues. Functional enrichment analysis revealed that the stiffened state was significantly associated with upregulation of vesicle-mediated transport systems and glycosaminoglycan metabolism, supporting the hypothesis of secretion-driven matrix remodeling. The softened state was characterized by enrichment in protein synthesis, ribosome biosynthesis, and oxidative phosphorylation pathways. Additionally, enrichment of Hippo signaling and DNA damage response terms was observed in the softened condition. Collectively, these data provide a proteomic resource for MCT state transitions and suggest that stiffening is associated with matrix remodeling. In contrast, softening is accompanied by shifts in metabolic homeostasis and stress-response programs. This research provides a systematic understanding of MCT's rapid reversibility and may inform the design of bioinspired mechanically adaptable materials. |
| WOS关键词 | HIPPO SIGNALING PATHWAY ; EXTRACELLULAR-MATRIX ; STIFFENING FACTOR ; L-FICOLIN ; ECHINODERMATA ; RECOGNITION ; OPHIUROIDEA ; TENSILIN ; BINDING ; DERMIS |
| 资助项目 | National Natural Science Foun-dation of China[42276143] ; Shandong Provin-cial Natural Science Foundation[ZR2024YQ050] ; Taishan Scholars Program[tsqn202306279] ; China Postdoctoral Science Foundation[2025M770873] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Genetics & Heredity |
| 语种 | 英语 |
| WOS记录号 | WOS:001730258800001 |
| 出版者 | ELSEVIER SCIENCE INC |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/205051]  |
| 专题 | 海洋研究所_海洋生态与环境科学重点实验室 |
| 通讯作者 | Sun, Lina |
| 作者单位 | 1.Chinese Acad Sci, Inst Oceanol, State Key Lab Breeding Biotechnol & Sustainable Aq, Qingdao 266000, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Inst Oceanol, Lab Marine Ecol & Environm Sci, Qingdao 266000, Peoples R China 4.Qingdao Marine Sci & Technol Ctr, Lab Marine Ecol & Environm Sci, Qingdao 266237, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wu, Qianwen,Su, Fang,Jiang, Chunxi,et al. Proteomic profiling reveals matrix remodeling and metabolic homeostasis in sea cucumber mutable collagenous tissue[J]. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY D-GENOMICS & PROTEOMICS,2026,59:10. |
| APA | Wu, Qianwen,Su, Fang,Jiang, Chunxi,Cui, Wei,&Sun, Lina.(2026).Proteomic profiling reveals matrix remodeling and metabolic homeostasis in sea cucumber mutable collagenous tissue.COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY D-GENOMICS & PROTEOMICS,59,10. |
| MLA | Wu, Qianwen,et al."Proteomic profiling reveals matrix remodeling and metabolic homeostasis in sea cucumber mutable collagenous tissue".COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY D-GENOMICS & PROTEOMICS 59(2026):10. |
入库方式： OAI收割
来源：海洋研究所
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