Purification, structural characterization, and anti-ulcerative colitis activity of a novel pectin-like polysaccharide AH-H4-1 from Alhagi honey
文献类型：期刊论文
| 作者 | Wang, Zhe4; Chi, Yaping4; Wang, Menghua2; Zhou, Qianqian4; Yan, Zexiang4; Xue, Rui4; Cai, Xiaoxia4; Tian, Jing4; Yu, Wei4; Yaermaimaiti, Saimijiang4 |
| 刊名 | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
 |
| 出版日期 | 2025-08-01 |
| 卷号 | 319页码:16 |
| 关键词 | Alhagi honey Pectin-like polysaccharide DSS-induced UC model Structural characterization |
| ISSN号 | 0141-8130 |
| DOI | 10.1016/j.ijbiomac.2025.145432 |
| 通讯作者 | Hu, Zelan(huzelan@ecust.edu.cn) ; Han, Bo(524683221@qq.com) |
| 英文摘要 | Alhagi honey (AH) has been employed in traditional medicine for treating intestinal diseases, demonstrating significant clinical efficacy. However, it remains unclear which components of AH play a role in the treatment of ulcerative colitis (UC). Here, high molecular weight polysaccharide (AH-H) and low molecular weight oligosaccharide (AH-L) were obtained from AH by dialysis. AH-H showed significant therapeutic activity in dextran sulfate sodium (DSS)-induced UC mouse model. In vitro experiment indicated that the component AH-H4-1 isolated from AH-H was a potential active ingredient. Structure analysis revealed that AH-H4-1 was primarily composed of galacturonic acid, rhamnose, galactose, and arabinose. Its structural backbone consists of 1,4-GalA, 1,2,4-Rha, and 1,2-Rha residues, with branches at the O-4 position of 1,2,4-Rha containing 1,3,6-Gal, 1,6-Gal, and 1,5-Ara. AH-H4-1 demonstrates therapeutic effects by reducing neutrophil accumulation in the intestine and promoting the repair of intestinal barrier function in zebrafish with DSS-induced UC. This study provides a valuable reference for AH in the treatment of UC, and establishes a phytochemical basis for developing AHderived therapeutics for the treatment of UC. |
| WOS关键词 | ELUCIDATION |
| 资助项目 | Financial science and technology plan project of Xinjiang[2023AB047] ; Financial science and technology plan project of Xinjiang[2022A03017] ; Na-tional Natural Science Foundation of China[82174075] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry ; Polymer Science |
| 语种 | 英语 |
| WOS记录号 | WOS:001533249800001 |
| 出版者 | ELSEVIER |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/318855]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Hu, Zelan; Han, Bo |
| 作者单位 | 1.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China 2.Shandong Univ, Sch Pharmaceut Sci, Jinan 250012, Peoples R China 3.East China Univ Sci & Technol, Shanghai Frontiers Sci Ctr Optogenet Tech Cell Met, Sch Pharm, Shanghai Key Lab New Drug Design, Shanghai 200237, Peoples R China 4.Shihezi Univ, Inst Safflower Ind Res, Sch Pharm,Minist Educ, Key Lab Xinjiang Phytomed Resource & Utilizat, Shihezi 832002, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Zhe,Chi, Yaping,Wang, Menghua,et al. Purification, structural characterization, and anti-ulcerative colitis activity of a novel pectin-like polysaccharide AH-H4-1 from Alhagi honey[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2025,319:16. |
| APA | Wang, Zhe.,Chi, Yaping.,Wang, Menghua.,Zhou, Qianqian.,Yan, Zexiang.,...&Han, Bo.(2025).Purification, structural characterization, and anti-ulcerative colitis activity of a novel pectin-like polysaccharide AH-H4-1 from Alhagi honey.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,319,16. |
| MLA | Wang, Zhe,et al."Purification, structural characterization, and anti-ulcerative colitis activity of a novel pectin-like polysaccharide AH-H4-1 from Alhagi honey".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 319(2025):16. |
入库方式： OAI收割
来源：上海药物研究所
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