Ion-Gradient Driven Drug-Loading Liposomes for Codelivery of Shikonin/Regorafenib for Cancer Immunometabolic Therapy and Postoperative Intervention
文献类型：期刊论文
| 作者 | Shao, Xinyue5,6,7; Peng, Taoxing4,7; Yang, Chenxiao3,7; Zhu, Jie6,7; Wang, Rui3,7; Yang, Lu2,7; Hou, Jiazhen2,7; Wang, Huiyuan7; Huang, Yongzhuo1,6,7 |
| 刊名 | ACS APPLIED MATERIALS & INTERFACES
 |
| 出版日期 | 2025-07-30 |
| 卷号 | 17期号:30页码:42735-42750 |
| 关键词 | Lactate Ion-gradient drug loading Combinationtherapy Tumor microenvironment Shikonin |
| ISSN号 | 1944-8244 |
| DOI | 10.1021/acsami.5c07923 |
| 通讯作者 | Wang, Huiyuan(wanghuiyuan@simm.ac.cn) ; Huang, Yongzhuo(yzhuang@simm.ac.cn) |
| 英文摘要 | Lactate emerges as a pivotal immunometabolite in tumor progression, orchestrating immunosuppression by polarizing tumor-associated macrophages (TAMs) toward pro-tumor M2 phenotypes and activating immunosuppressive cell populations. Targeting intratumoral lactate has emerged as a promising therapeutic strategy for tumors with poor immune responses. Shikonin (SHK) inhibited the lactate production of tumor cells by targeting pyruvate kinase M2 (PKM2). Regorafenib (REGO), an FDA-approved multikinase inhibitor, repolarized TAMs from M2-like to tumor-suppressive M1 phenotypes. To overcome their clinical limitations of off-targeting and systemic toxicity, a T12 peptide-modified liposome (T12-SR-LP) was constructed to encapsulate SHK and REGO through an ion-gradient method. T12-SR-LP exhibited a high total drug loading efficiency of 10.5%, attributed to copper ion-mediated coordination. Furthermore, the hydrogel with T12-SR-LP (T12-SR-LP@Gel) significantly suppressed tumor growth and recurrence compared to controls. This study highlighted T12-SR-LP as a promising strategy targeting both the metabolic and immune facets of the tumor microenvironment to combat "cold" tumors with poor immune activity. |
| WOS关键词 | METASTASIS ; DELIVERY ; SHIKONIN ; CELLS |
| 资助项目 | National Key Research and Development Program of China[2024YFA1210200] ; National Key Research and Development Program of China[2022YFE0203600] ; Natural Science Foundation of Shanghai Municipal[82304842] ; International Partnership Program of Chinese Academy of Sciences[083GJHZ2023021GC] ; International Partnership Program of Chinese Academy of Sciences[083GJHZ2023012FN] ; Chinese Academy of Sciences President's International Fellowship Initiative[2024VBB0004] ; Department of Science and Technology of Guangdong Province[2021B0909050003] ; Scientific research and innovation projects of Zhongshan City[LJ2021001] ; Scientific research and innovation projects of Zhongshan City[CXTD2022011] ; Scientific research and innovation projects of Zhongshan City[2023B2033] |
| WOS研究方向 | Science & Technology - Other Topics ; Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:001531640000001 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/318858]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Wang, Huiyuan; Huang, Yongzhuo |
| 作者单位 | 1.Chinese Acad Sci, Zhongshan Inst Drug Discovery, Inst Drug Discovery & Dev, Zhongshan 528437, Peoples R China 2.Nanjing Univ Chinese Med, Sch Chinese Mat Med, Nanjing 210023, Peoples R China 3.Nanchang Univ, Coll Pharm, Nanchang 330006, Peoples R China 4.Nanchang Univ, MOE Basic Res & Innovat Ctr Targeted Therapeut Sol, Jiangxi Prov Key Lab Precis Pathol & Intelligent D, Postdoctoral Innovat Practice Base,Affiliated Hosp, Nanchang 330006, Peoples R China 5.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China 6.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 7.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Shao, Xinyue,Peng, Taoxing,Yang, Chenxiao,et al. Ion-Gradient Driven Drug-Loading Liposomes for Codelivery of Shikonin/Regorafenib for Cancer Immunometabolic Therapy and Postoperative Intervention[J]. ACS APPLIED MATERIALS & INTERFACES,2025,17(30):42735-42750. |
| APA | Shao, Xinyue.,Peng, Taoxing.,Yang, Chenxiao.,Zhu, Jie.,Wang, Rui.,...&Huang, Yongzhuo.(2025).Ion-Gradient Driven Drug-Loading Liposomes for Codelivery of Shikonin/Regorafenib for Cancer Immunometabolic Therapy and Postoperative Intervention.ACS APPLIED MATERIALS & INTERFACES,17(30),42735-42750. |
| MLA | Shao, Xinyue,et al."Ion-Gradient Driven Drug-Loading Liposomes for Codelivery of Shikonin/Regorafenib for Cancer Immunometabolic Therapy and Postoperative Intervention".ACS APPLIED MATERIALS & INTERFACES 17.30(2025):42735-42750. |
入库方式： OAI收割
来源：上海药物研究所
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