Identification and biomimetic synthesis of iphionanes and cyperanes from Artemisia hedinii and their anti-hepatic fibrosis activity
文献类型：期刊论文
| 作者 | Liu, Xiaofei3,4,5; Wang, Xing3,4,5; Tang, Chunping4,5; Ke, Changqiang4,5; Hu, Bintao4,5; Yao, Sheng2,3,4,5; Ye, Yang1,3,4,5 |
| 刊名 | CHINESE JOURNAL OF NATURAL MEDICINES
 |
| 出版日期 | 2025-07-01 |
| 卷号 | 23期号:7页码:871-880 |
| 关键词 | Artemisia hedinii Iphionane Cyperane New skeleton Biomimetic synthesis Anti-hepatic fibrosis |
| ISSN号 | 2095-6975 |
| DOI | 10.1016/S1875-5364(25)60915-0 |
| 通讯作者 | Hu, Bintao(hubintao@simm.ac.cn) ; Yao, Sheng(yaosheng@simm.ac.cn) ; Ye, Yang(yye@simm.ac.cn) |
| 英文摘要 | Two novel skeleton sesquiterpenoids (1 and 6), along with four new iphionane-type sesquiterpenes (2-5) and six new cyperane-type sesquiterpenes (7-11), were isolated from the whole plant of Artemisia hedinii (A. hedinii). The two novel skeleton compounds (1 and 6) were derived from the decarbonization of iphionane and cyperane-type sesquiterpenes, respectively. Their structures were elucidated through a comprehensive analysis of spectroscopic data, including high-resolution electrospray ionization mass spectrometry (HR-ESI-MS) and 1D and 2D nuclear magnetic resonance (NMR) spectra. The absolute configurations were determined using electronic circular dichroism (ECD) spectra, single-crystal X-ray crystallographic analyses, time-dependent density functional theory (TDDFT) ECD calculation, density functional theory (DFT) NMR calculations, and biomimetic syntheses. The biomimetic syntheses of the two novel skeletons (1 and 6) were inspired by potential biogenetic pathways, utilizing a predominant eudesmane-type sesquiterpene (A) in A. hedinii as the substrate. All compounds were evaluated in LX-2 cells for their anti-hepatic fibrosis activity. Compounds 2, 8, and 10 exhibited significant activity in downregulating the expression of alpha- smooth muscle actin (alpha-SMA), a protein involved in hepatic fibrosis. |
| WOS关键词 | ABSOLUTE-CONFIGURATION ; SESQUITERPENOIDS ; MONOTERPENES |
| 资助项目 | National Natural Science Foundation of China[21920102003] ; Key-Area Research and Development Program of Guangdong Province[2020B0303070002] ; National Key R&D Program Strategic Scientific and Technological Innovation Cooperation Key Project[2022YFE0203600] |
| WOS研究方向 | Integrative & Complementary Medicine ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:001530922300001 |
| 出版者 | CHINESE JOURNAL NATURAL MEDICINES |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/318867]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Hu, Bintao; Yao, Sheng; Ye, Yang |
| 作者单位 | 1.Shanghai Tech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China 2.Chinese Acad Sci, Zhongshan Inst Drug Discovery, Shanghai Inst Mat Med, Zhongshan 528400, Peoples R China 3.Univ Chinese Acad Sci, Sch Pharm, Beijing 100049, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Mat Med, Nat Prod Res Ctr, Shanghai 201203, Peoples R China 5.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Xiaofei,Wang, Xing,Tang, Chunping,et al. Identification and biomimetic synthesis of iphionanes and cyperanes from Artemisia hedinii and their anti-hepatic fibrosis activity[J]. CHINESE JOURNAL OF NATURAL MEDICINES,2025,23(7):871-880. |
| APA | Liu, Xiaofei.,Wang, Xing.,Tang, Chunping.,Ke, Changqiang.,Hu, Bintao.,...&Ye, Yang.(2025).Identification and biomimetic synthesis of iphionanes and cyperanes from Artemisia hedinii and their anti-hepatic fibrosis activity.CHINESE JOURNAL OF NATURAL MEDICINES,23(7),871-880. |
| MLA | Liu, Xiaofei,et al."Identification and biomimetic synthesis of iphionanes and cyperanes from Artemisia hedinii and their anti-hepatic fibrosis activity".CHINESE JOURNAL OF NATURAL MEDICINES 23.7(2025):871-880. |
入库方式： OAI收割
来源：上海药物研究所
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