IL-6 Inhibition Partially Ameliorates Maternal Immune Activation-Induced Autism-Like Behavioral Abnormalities in Mice
文献类型：期刊论文
| 作者 | Zhang, Xiaoyun3; Luo, Weili2; He, Kaiyue1; Li, Yuping3; Chen, Yan2; Xu, Zhipeng1; Zhou, Zi-Kai2,3 |
| 刊名 | CURRENT ISSUES IN MOLECULAR BIOLOGY
 |
| 出版日期 | 2025-10-16 |
| 卷号 | 47期号:10页码:13 |
| 关键词 | maternal immune activation autism spectrum disorder interleukin-6 behavioral tests |
| ISSN号 | 1467-3037 |
| DOI | 10.3390/cimb47100852 |
| 通讯作者 | Xu, Zhipeng(zhipengxu@njmu.edu.cn) ; Zhou, Zi-Kai(zhouzikai@zidd.ac.cn) |
| 英文摘要 | Prenatal maternal immune activation (MIA) has been implicated in autism spectrum disorder (ASD) pathogenesis, with interleukin-6 (IL-6) identified as a key inflammatory mediator. We investigated the therapeutic potential of IL-6 inhibition in an MIA mouse model induced by Toxoplasma gondii soluble tachyzoite antigen (STAg). Adult MIA offspring received systemic administration of the IL-6-neutralizing antibody (MP5-20F3) or isotype control, followed by behavioral assessments one week later. Open field and elevated plus maze tests revealed heightened anxiety-like behaviors in the STAg offspring, which were largely reversed by IL-6 inhibition. Reciprocal social interaction tests showed diminished sociability in the STAg offspring, which was partially restored by IL-6 inhibition. However, core ASD-like features, including impaired social preference and recognition in the three-chamber test, as well as increased repetitive behaviors, remained resistant to IL-6 inhibition. These findings demonstrate that STAg-induced MIA elicits anxiety-like and ASD-like phenotypes in adult offspring, with IL-6 playing an important role in anxiety-like behaviors and social interaction deficits. Systemic IL-6 inhibition partially ameliorates behavioral abnormalities. This study suggests that IL-6-targeted therapies may address a subset of ASD-related symptoms, and comprehensive strategies are needed for broader efficacy. |
| WOS关键词 | BRAIN ; INTERLEUKIN-6 ; CONNECTIVITY ; INFLAMMATION ; RESPONSES ; MODELS ; LEADS |
| 资助项目 | Zhongshan Municipal Bureau of Science and Technology[CXTD2022013] ; Zhongshan Municipal Bureau of Science and Technology[2022B2016] ; Zhongshan Institute for Drug Discovery[SQ2302-12] ; Science and Technology Commission of Shanghai Municipal[24ZR1477800] ; Science and Technology Commission of Shanghai Municipal[22YF1456800] ; Chinese Academy of Science[E2G709R0Z1] |
| WOS研究方向 | Biochemistry & Molecular Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:001602572000001 |
| 出版者 | MDPI |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/319733]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Xu, Zhipeng; Zhou, Zi-Kai |
| 作者单位 | 1.Nanjing Med Univ, Dept Pathogen Biol & Immunol, State Key Lab Reprod Med & Offspring Hlth, Nanjing 211166, Peoples R China 2.Guizhou Med Univ, Sch Pharmaceut Sci, State Key Lab Discovery & Utilizat Funct Component, Guiyang 561113, Peoples R China 3.Chinese Acad Sci, Zhongshan Inst Drug Discovery, Shanghai Inst Mat Med, Zhongshan 528400, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Xiaoyun,Luo, Weili,He, Kaiyue,et al. IL-6 Inhibition Partially Ameliorates Maternal Immune Activation-Induced Autism-Like Behavioral Abnormalities in Mice[J]. CURRENT ISSUES IN MOLECULAR BIOLOGY,2025,47(10):13. |
| APA | Zhang, Xiaoyun.,Luo, Weili.,He, Kaiyue.,Li, Yuping.,Chen, Yan.,...&Zhou, Zi-Kai.(2025).IL-6 Inhibition Partially Ameliorates Maternal Immune Activation-Induced Autism-Like Behavioral Abnormalities in Mice.CURRENT ISSUES IN MOLECULAR BIOLOGY,47(10),13. |
| MLA | Zhang, Xiaoyun,et al."IL-6 Inhibition Partially Ameliorates Maternal Immune Activation-Induced Autism-Like Behavioral Abnormalities in Mice".CURRENT ISSUES IN MOLECULAR BIOLOGY 47.10(2025):13. |
入库方式： OAI收割
来源：上海药物研究所
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