Deformable hyaluronic acid niosomes overcome multi-barriers for improved ergothioneine transdermal delivery against UV-induced skin damage
文献类型：期刊论文
| 作者 | Li, Lijun4,5; Guo, Chenliang2; Fang, Yuelin3; Cheng, Zijian4,5; Li, Yaowei1; Wang, Zhangyu4,5; Cai, Dian4,5; Xu, Yuqi4,5; Liu, Wenqi3; Ma, Shouwei2 |
| 刊名 | CHINESE CHEMICAL LETTERS
 |
| 出版日期 | 2025-11-01 |
| 卷号 | 36期号:11页码:8 |
| 关键词 | Transdermal delivery Ergothioneine Deformability Niosomes UV-induced skin damage |
| ISSN号 | 1001-8417 |
| DOI | 10.1016/j.cclet.2025.110839 |
| 通讯作者 | Ma, Shouwei(mashouwei306@163.com) ; Zhang, Xinxin(xinxinzhang@simm.ac.cn) |
| 英文摘要 | The complex skin structure and insufficient intracellular entrapment limit the therapeutic effects of active substances, therefore appealing to a more effective transdermal drug delivery system design. Herein, a hyaluronic acid (HA) modified steareth-2-based niosomes (HA-nio) with satisfactory deformability and targeting properties was designed for ergothioneine (EGT) (EGT@HA-nio) against ultraviolet (UV)-induced skin damage. The unique composition allows EGT@HA-nio to exhibit high mechanical softness, making it deformable to pass through the stratum corneum by the intercellular space without rupture. For further intracellular delivery, HA modification enables EGT to target human dermal cells (HDFs) with increased distribution in mitochondria without the restriction of specific EGT transporter-organic cation transporter 1 (OCTN-1). Benefiting from the above properties, an adequate amount of EGT in the active form was accumulated in the desired cellular sites, alleviating UV-radiation-induced reactive oxygen species (ROS) generation, inflammatory factor release, DNA damage, and mitochondrial dysfunction. The in vivo experimental results show that EGT@HA-nio could significantly decrease collagen degradation, restore epidermal thickness and morphology to healthy levels, and effectively prevent UV-induced skin damage. With the ability to penetrate biological barriers and deliver drugs, HA-nio may promote the development of inadequate drug penetration disease treatment including skin diseases, cancers, and bacterial infections. (c) 2025 Published by Elsevier B.V. on behalf of Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. |
| WOS关键词 | DRUG-DELIVERY ; FORMULATIONS |
| 资助项目 | National Natural Science Foundation of China[82222066] ; National Key Research and Development Program of China[2022YFC2304104] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:001605585700008 |
| 出版者 | ELSEVIER SCIENCE INC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/319748]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Ma, Shouwei; Zhang, Xinxin |
| 作者单位 | 1.Nanjing Univ Chinese Med, Sch Chinese Mat Med, Nanjing 210023, Peoples R China 2.Bloomage Biotechnol Corp Ltd, Shanghai 201304, Peoples R China 3.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264117, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 5.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Lijun,Guo, Chenliang,Fang, Yuelin,et al. Deformable hyaluronic acid niosomes overcome multi-barriers for improved ergothioneine transdermal delivery against UV-induced skin damage[J]. CHINESE CHEMICAL LETTERS,2025,36(11):8. |
| APA | Li, Lijun.,Guo, Chenliang.,Fang, Yuelin.,Cheng, Zijian.,Li, Yaowei.,...&Zhang, Xinxin.(2025).Deformable hyaluronic acid niosomes overcome multi-barriers for improved ergothioneine transdermal delivery against UV-induced skin damage.CHINESE CHEMICAL LETTERS,36(11),8. |
| MLA | Li, Lijun,et al."Deformable hyaluronic acid niosomes overcome multi-barriers for improved ergothioneine transdermal delivery against UV-induced skin damage".CHINESE CHEMICAL LETTERS 36.11(2025):8. |
入库方式： OAI收割
来源：上海药物研究所
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