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Discovery and Biosynthesis of Lipolasso Peptides Reveal CoA-transferase for Tyrosine Lipidation of Ribosomal Peptides

文献类型：期刊论文

作者Li, Yuan-Yuan4; Li, Xin-Rong4; Lu, Jin-Long4; Cui, Jiao-Jiao4; Zhai, Weikang4; Xiong, Jiang4; Han, Hongping3; Gao, Kun4; Lei, Xinxiang4; Zhang, Chuan-Rui1,2
刊名ORGANIC LETTERS
出版日期2025-10-31
卷号27期号:43页码:12148-12153
ISSN号1523-7060
DOI10.1021/acs.orglett.5c03981
通讯作者Zhang, Chuan-Rui(zhangchuanrui@simm.ac.cn) ; Luo, Shangwen(luosw@lzu.edu.cn) ; Dong, Shi-Hui(dongsh@lzu.edu.cn)
英文摘要Lipopeptides are bioactive molecules typically produced via nonribosomal pathways. Only four types of lipidated ribosomally synthesized and post-translationally modified peptides (RiPPs) are known, all modified on amine groups by GNAT enzymes. We report an unprecedented biosynthetic gene cluster combining lasso peptide biosynthesis and acyl-CoA metabolism that produces a novel family of lipolasso peptides. A crotonobetainyl-CoA:carnitine CoA-transferase lipidates the Tyr hydroxy group within precursor peptides, revealing a distinct RiPP lipidation strategy. This work expands the paradigm of ribosomal lipopeptide biosynthesis.
WOS关键词CRYSTAL-STRUCTURE ; LASSO PEPTIDES ; IDENTIFICATION ; MECHANISM ; CAIB
资助项目National Natural Science Foundation of China[22477050] ; National Natural Science Foundation of China[22077056] ; National Natural Science Foundation of China[KJZD20240903101104007] ; Shenzhen Science and Technology Program[22ZD6FA006] ; Shenzhen Science and Technology Program[23ZDFA015] ; Shenzhen Science and Technology Program[24ZD13FA017] ; Science and Technology Major Program of Gansu Province of China[lzujbky-2024-06] ; Fundamental Research Funds for the Central Universities
WOS研究方向Chemistry
语种英语
WOS记录号WOS:001598376400001
出版者AMER CHEMICAL SOC
源URL[http://119.78.100.183/handle/2S10ELR8/320738]  
专题中国科学院上海药物研究所
通讯作者Zhang, Chuan-Rui; Luo, Shangwen; Dong, Shi-Hui
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
2.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264117, Shandong, Peoples R China
3.Qinghai Normal Univ, Acad Plateau Sci & Sustainabil, Xining 810016, Peoples R China
4.Lanzhou Univ, Coll Chem & Chem Engn, Sch Pharm, State Key Lab Nat Prod Chem, Lanzhou 730000, Peoples R China
推荐引用方式
GB/T 7714		 Li, Yuan-Yuan,Li, Xin-Rong,Lu, Jin-Long,et al. Discovery and Biosynthesis of Lipolasso Peptides Reveal CoA-transferase for Tyrosine Lipidation of Ribosomal Peptides[J]. ORGANIC LETTERS,2025,27(43):12148-12153.
APA Li, Yuan-Yuan.,Li, Xin-Rong.,Lu, Jin-Long.,Cui, Jiao-Jiao.,Zhai, Weikang.,...&Dong, Shi-Hui.(2025).Discovery and Biosynthesis of Lipolasso Peptides Reveal CoA-transferase for Tyrosine Lipidation of Ribosomal Peptides.ORGANIC LETTERS,27(43),12148-12153.
MLA Li, Yuan-Yuan,et al."Discovery and Biosynthesis of Lipolasso Peptides Reveal CoA-transferase for Tyrosine Lipidation of Ribosomal Peptides".ORGANIC LETTERS 27.43(2025):12148-12153.

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来源：上海药物研究所

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