Cantharidin-Loaded Nanomedicine Modified with Amphiphilic Peptides Induce Immunogenic Cell Death to Enhance PD-1 Blockade
文献类型：期刊论文
| 作者 | Tang, Yang3; Jiang, Qun2; Chen, Rongli1; Wu, Siqi2; Luo, Yichang3; Huang, Xi3; Yu, Guofang3; Shao, Cui3 |
| 刊名 | ACS APPLIED MATERIALS & INTERFACES
 |
| 出版日期 | 2025-07-23 |
| 卷号 | 17期号:29页码:41571-41585 |
| 关键词 | cantharidin amphiphilic peptide immunogeniccell death PD-1 blockade tumor microenvironment |
| ISSN号 | 1944-8244 |
| DOI | 10.1021/acsami.5c05498 |
| 通讯作者 | Tang, Yang(2020620691@gzhmu.edu.cn) ; Shao, Cui(shaocui2022@sina.com) |
| 英文摘要 | Recent advances in immune checkpoint inhibitors (ICIs), particularly those targeting PD-1/PD-L1, have transformed cancer treatment. However, their efficacy is often hampered by the immunosuppressive tumor microenvironment (TME). Here, we developed a cantharidin-loaded nanomedicine (CA@TPGS-AmP), composed of D-alpha-tocopheryl polyethylene glycol succinate (TPGS) and naturally derived amphiphilic peptides (AmP), designed to enhance PD-1 blockade via induction of immunogenic cell death (ICD). In vitro, CA@TPGS-AmP markedly improved the solubility of cantharidin and exhibited superior penetration in 3D tumor spheroids. It effectively triggered key ICD events, including calreticulin (CRT) surface exposure, ATP release, and HMGB1 translocation, thereby promoting dendritic cell (DC) maturation. In vivo, CA@TPGS-AmP significantly augmented the antitumor efficacy of PD-1 therapy in 4T1 orthotopic breast cancer and LLC lung cancer models. Mechanistically, the combination therapy remodeled the TME into an immunostimulatory state by increasing CD8+ T cell infiltration and activation, leading to enhanced tumor suppression compared to monotherapies. These findings support CA@TPGS-AmP as a promising adjunct to PD-1 blockade and highlight the potential of natural product-based nanomedicine in advancing cancer immunotherapy. |
| WOS关键词 | CANCER ; NANOFORMULATION ; DELIVERY |
| 资助项目 | National Natural Science Foundation of China[82305177] ; Guangzhou Traditional Chinese Medicine and Integrated Traditional Chinese and Western Medicine Science and Technology Project[20222A011007] ; Joint Project of the Guangzhou Science and Technology Bureau and Universities/Institutes/Enterprises[2025A03J3517] |
| WOS研究方向 | Science & Technology - Other Topics ; Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:001524626600001 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/321048]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Tang, Yang; Shao, Cui |
| 作者单位 | 1.Chinese Acad Sci, Zhongshan Inst Drug Discovery, Shanghai Inst Mat Med, Zhongshan 528437, Peoples R China 2.Guangzhou Univ Chinese Med, Guangzhou 510000, Peoples R China 3.Guangzhou Med Univ, Affiliated Tradit Chinese Med Hosp, Dept Oncol, Guangzhou 510000, Peoples R China |
| 推荐引用方式 GB/T 7714 | Tang, Yang,Jiang, Qun,Chen, Rongli,et al. Cantharidin-Loaded Nanomedicine Modified with Amphiphilic Peptides Induce Immunogenic Cell Death to Enhance PD-1 Blockade[J]. ACS APPLIED MATERIALS & INTERFACES,2025,17(29):41571-41585. |
| APA | Tang, Yang.,Jiang, Qun.,Chen, Rongli.,Wu, Siqi.,Luo, Yichang.,...&Shao, Cui.(2025).Cantharidin-Loaded Nanomedicine Modified with Amphiphilic Peptides Induce Immunogenic Cell Death to Enhance PD-1 Blockade.ACS APPLIED MATERIALS & INTERFACES,17(29),41571-41585. |
| MLA | Tang, Yang,et al."Cantharidin-Loaded Nanomedicine Modified with Amphiphilic Peptides Induce Immunogenic Cell Death to Enhance PD-1 Blockade".ACS APPLIED MATERIALS & INTERFACES 17.29(2025):41571-41585. |
入库方式： OAI收割
来源：上海药物研究所
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